Results 121 to 130 of about 4,071 (219)

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions

open access: yesJCI Insight, 2020
In the aging population, lower urinary tract (LUT) dysfunction is common and often leads to storage and voiding difficulties classified into overlapping symptom syndromes.
Lori A. Birder   +12 more
doaj   +1 more source

AU-Rich Long 3′ Untranslated Region Regulates Gene Expression in Bacteria

open access: yesFrontiers in Microbiology, 2018
3′ untranslated regions (3′ UTRs) and particularly long 3′ UTRs have been shown to act as a new class of post-transcriptional regulatory element. We previously reported that hmsT mRNA stability is negatively regulated by the 3′ UTR of hmsT in Yersinia ...
Ju-Ping Zhao   +3 more
doaj   +1 more source

Characterization of the RNase R association with ribosomes [PDF]

open access: yes, 2014
BACKGROUND: In this study we employed the TAP tag purification method coupled with mass spectrometry analysis to identify proteins that co-purify with Escherichia coli RNase R during exponential growth and after temperature downshift.
Cecilia M Arraiano   +2 more
core   +1 more source

Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches

open access: yesCells, 2019
Mitochondria harbor their own genetic system, yet critically depend on the import of a number of nuclear-encoded macromolecules to ensure their expression.
Damien Jeandard   +5 more
doaj   +1 more source

Enzymatic Synthesis and Fractionation of Fluorescent PolyU RNAs

open access: yesBio-Protocol, 2018
The physical properties of viral-length polyuridine (PolyU) RNAs, which cannot base-pair and form secondary structures, are compared with those of normal-composition RNAs, composed of comparable numbers of each of A, U, G and C nucleobases.
Christian Beren   +4 more
doaj   +1 more source

A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation

open access: yesStem Cell Reports, 2017
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is accompanied by morphological, functional, and metabolic alterations before acquisition of full pluripotency.
Ken Nishimura   +13 more
doaj   +1 more source

The majority of Escherichia coli mRNAs undergo post-transcriptional modification in exponentially growing cells [PDF]

open access: yes, 2006
Polyadenylation of RNAs by poly(A) polymerase I (PAP I) in Escherichia coli plays a significant role in mRNA decay and general RNA quality control. However, many important features of this system, including the prevalence of polyadenylated mRNAs in the ...
Aiso   +35 more
core   +2 more sources

RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact

open access: yesInternational Journal of Genomics, 2015
The regulation of RNA decay is now widely recognized as having a central role in bacterial adaption to environmental stress. Here we present an overview on the diversity of ribonucleases (RNases) and their impact at the posttranscriptional level in the ...
Rémy A. Bonnin, Philippe Bouloc
doaj   +1 more source

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