Results 101 to 110 of about 4,003 (181)

Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

Nature Communications, 2018
G-rich RNAs encoded in mitochondrial DNA are prone to form four-stranded structures called G-quadruplexes (G4s). Here the authors show using in vitro and in vivo approaches that GRSF1 promotes melting of G4 RNA structures in mtRNAs, thus leading to their
Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski, Roman J. Szczesny   +8 more
doaj   +1 more source

LncRNA Binding to Mitochondrial PNPase

Long non-coding RNAs (lncRNAs) are relatively novel RNAs with increasingly prominent roles in regulating genetic expression, mainly in the nucleus but more recently in regions such as the mitochondrion.
Andrew Taylor (18368502)
core   +1 more source

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions

JCI Insight, 2020
In the aging population, lower urinary tract (LUT) dysfunction is common and often leads to storage and voiding difficulties classified into overlapping symptom syndromes.
Lori A. Birder, Amanda Wolf-Johnston, Alan J. Wein, Fangzhou Cheng, Mara Grove-Sullivan, Anthony J. Kanai, Alan M. Watson, Donna Stoltz, Simon C. Watkins, Anne M. Robertson, Diane Newman, Roger R. Dmochowski, Edwin K. Jackson   +12 more
doaj   +1 more source

Identification and characterization of the minimal promoter region of the mouse polynucleotide phosphorylase (PNPase) gene [PDF]

, 2008
Polynucleotide phosphorylases (PNPase) are evolutionary conserved enzymes that are known to exist in a variety of organisms. They exhibit a 3 '-5 ', exoribonuclease activity, are found in the mitochondria of cells and play a central role in RNA ...
Loya, Ruchika G.
core  

The Protein Interaction of RNA Helicase B (RhlB) and Polynucleotide Phosphorylase (PNPase) Contributes to the Homeostatic Control of Cysteine in Escherichia coli

, 2017
PNPase, one of the major enzymes with 3' to 5' single-stranded RNA degradation and processing activities, can interact with the RNA helicase RhlB independently of RNA degradosome formation in Escherichia coli.
Tseng, Yi-Ting;Chiou, Ni-Ting;Gogiraju, Rajinikanth;Lin-Chao, Sue
core   +1 more source

RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact

International Journal of Genomics, 2015
The regulation of RNA decay is now widely recognized as having a central role in bacterial adaption to environmental stress. Here we present an overview on the diversity of ribonucleases (RNases) and their impact at the posttranscriptional level in the ...
Rémy A. Bonnin, Philippe Bouloc
doaj   +1 more source

Crystallization and preliminary X-ray diffraction studies of Xanthomonas campestris PNPase in the presence of c-di-GMP

, 2012
Bacterial polynucleotide phosphorylase (PNPase) is a 3'-5' processive exoribonuclease that participates in mRNA turnover and quality control of rRNA precursors in many bacterial species.
Liang, Zhao-Xun, Wang, Yu-Chuan, Chou, Shan-Ho, Chuah, Mary Lay-Cheng, Chin, Ko-Hsin   +4 more
core   +1 more source

Rapid and scalable detection of synthetic mRNA byproducts using polynucleotide phosphorylase and polythymidine oligonucleotides

RNA Biology
Production and storage of synthetic mRNA can introduce a variety of byproducts which reduce the overall integrity and functionality of mRNA vaccines and therapeutics.
Francis Combes, Thanh-Huong Bui, Frida J. Pettersson, Sjoerd Hak   +3 more
doaj   +1 more source

Controlling Localization and Function of Polynucleotide Phosphorylase (PNPase) to modulate the accumulation of mitochondrial double-stranded ribonucleic acids (mtdsRNA) [PDF]

Polynucleotide phosphorylase (PNPase) is a critical regulator of mitochondrial double-stranded RNA (mtdsRNA) homeostasis. Loss of PNPase leads to the export of mtdsRNA to the cytosol, triggering a Type-I interferon response via the MDA5-MAVS signaling ...
Short, Connor W.
core  

Structural Insights into the Rrp4 Subunit from the Crystal Structure of the Thermoplasma acidophilum Exosome

Biomolecules
The exosome multiprotein complex plays a critical role in RNA processing and degradation. This system governs the regulation of mRNA quality, degradation in the cytoplasm, the processing of short noncoding RNA, and the breakdown of RNA fragments.
Seonha Park, Hyun Sook Kim, Kyuhyeon Bang, Ahreum Han, Byeongmin Shin, Minjeong Seo, Sulhee Kim, Kwang Yeon Hwang   +7 more
doaj   +1 more source