Results 111 to 120 of about 4,319 (202)
An analytic approximation of the feasible space of metabolic networks
, 2017 Assuming a steady-state condition within a cell, metabolic fluxes satisfy an under-determined linear system of stoichiometric equations. Characterizing the space of fluxes that satisfy such equations along with given bounds (and possibly additional ...
Braunstein, Alfredo +2 more
core +1 more source
Stem Cell Reports, 2017 Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is accompanied by morphological, functional, and metabolic alterations before acquisition of full pluripotency.
Ken Nishimura +13 more
doaj +1 more source
Enzymatic Synthesis and Fractionation of Fluorescent PolyU RNAs
Bio-Protocol, 2018 The physical properties of viral-length polyuridine (PolyU) RNAs, which cannot base-pair and form secondary structures, are compared with those of normal-composition RNAs, composed of comparable numbers of each of A, U, G and C nucleobases.
Christian Beren +4 more
doaj +1 more source
RNA Degradation in Staphylococcus aureus: Diversity of Ribonucleases and Their Impact
International Journal of Genomics, 2015 The regulation of RNA decay is now widely recognized as having a central role in bacterial adaption to environmental stress. Here we present an overview on the diversity of ribonucleases (RNases) and their impact at the posttranscriptional level in the ...
Rémy A. Bonnin, Philippe Bouloc
doaj +1 more source
PLoS Pathogens, 2019 Numerous Gram-negative pathogens use a Type III Secretion System (T3SS) to promote virulence by injecting effector proteins into targeted host cells, which subvert host cell processes.
Maria Kusmierek +8 more
doaj +1 more source
RNase R vs. PNPase: selecting the best-suited exoribonuclease for environmental adaptation
Extremophiles3' → 5' exoribonucleases play a critical role in many aspects of RNA metabolism. RNase R, PNPase, and RNase II are the major contributors to RNA processing, maturation, and quality control in bacteria. Bacteria don't seem to have dedicated RNA degradation machineries to process different classes of RNAs.
openaire +4 more sources
LncRNA Binding to Mitochondrial PNPase
Long non-coding RNAs (lncRNAs) are relatively novel RNAs with increasingly prominent roles in regulating genetic expression, mainly in the nucleus but more recently in regions such as the mitochondrion. This study explores how lncRNAs interact with PNPase, a protein that regulates RNA import into the mitochondrion.
openaire +1 more source
BiomoleculesThe exosome multiprotein complex plays a critical role in RNA processing and degradation. This system governs the regulation of mRNA quality, degradation in the cytoplasm, the processing of short noncoding RNA, and the breakdown of RNA fragments.
Seonha Park +7 more
doaj +1 more source
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression [PDF]
, 2017 The p.N478D missense mutation in human mitochondrial poly(A) polymerase (mtPAP) has previously been implicated in a form of spastic ataxia with optic atrophy. In this study, we have investigated fibroblast cell lines established from family members.
Baslé, Arnaud +17 more
core
Evidence That the P\u3csub\u3ei\u3c/sub\u3e Release Event Is the Rate-Limiting Step in the Nitrogenase Catalytic Cycle [PDF]
, 2016 Nitrogenase reduction of dinitrogen (N2) to ammonia (NH3) involves a sequence of events that occur upon the transient association of the reduced Fe protein containing two ATP molecules with the MoFe protein that includes electron transfer, ATP hydrolysis,
Antony, Edwin +13 more
core +1 more source