Results 111 to 120 of about 48,174 (296)

Podocytes [PDF]

The American Journal of Pathology, 2020
Marica Giliberti, Adele Mitrotti, Loreto Gesualdo   +2 more
openaire   +1 more source

Investigate the Effects of Preeclampsia Severity, Race and Fetal Sex on Subsequent Maternal Complications Using EHR Data From Over 100,000 Pregnancies

iMetaMed, EarlyView.
We examined Preeclampsia‐associated comorbidities in the UM Discovery Cohort using confounder‐adjusted models, validated across UK Biobank, Cedars‐Sinai, and Vanderbilt, revealing condition‐specific risks supported by OR estimates and KM survival curves.
Xiaotong Yang, Haoming Zhu, Leyang Tao, Raelynn Chen, Jui‐Hsuan Chang, Zhiping P. Wang, Elizabeth S. Langen, Ashley M. Hesson, Cosmin A. Bejan, Ruowang Li, Lana X. Gamire   +10 more
wiley   +1 more source

Podocytes in health and glomerular disease

Frontiers in Cell and Developmental Biology
Podocytes are highly specialized, terminally differentiated cells in the glomerulus of the kidney and these cells play a central role in blood filtration.
Joanna Cunanan, Joanna Cunanan, Joanna Cunanan, Daniel Zhang, Daniel Zhang, Daniel Zhang, Anna Julie Peired, Moumita Barua, Moumita Barua, Moumita Barua   +9 more
doaj   +1 more source

Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases

The Journal of Clinical Investigation, 2023
The progression of proteinuric kidney diseases is associated with podocyte loss, but the mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to repair double-stranded DNA breaks.
Xuefei Tian, Christopher E. Pedigo, Ke Li, Xiaotao Ma, Patricia Bunda, John Pell, Angela Lek, Jianlei Gu, Yan Zhang, Paulina X. Medina Rangel, Wei Li, Eike Schwartze, Soichiro Nagata, Gabriel Lerner, Sudhir Perincheri, Anupama Priyadarshini, Hongyu Zhao, Monkol Lek, Madhav C. Menon, Rongguo Fu, Shuta Ishibe   +20 more
doaj   +1 more source

Isorhamnetin Alleviates Renal Fibrosis Induced by Renal Tubular Epithelial Cell Senescence Via Inhibition of the IL‐6/IL‐6R Signaling Pathway

iMetaMed, EarlyView.
IL‐6 from RTECs upregulates TGF‐β in macrophages, promoting fibroblast transdifferentiation. Isorhamnetin inhibits this effect. ABSTRACT Chronic kidney disease (CKD) is a major global health issue. Kidney fibrosis is a key mechanism leading to end‐stage renal disease.
Weifei Liang, Xiangqiu Chen, Tao Wu, Xichun Zheng, Shaohua Zeng, Qingchun Zhou, Wen Ma, Hao Lin, Donglin Sun   +8 more
wiley   +1 more source

Role of Podocyte Injury in Glomerulosclerosis

Advances in Experimental Medicine and Biology, 2019
Finding new therapeutic targets of glomerulosclerosis treatment is an ongoing quest. Due to a living environment of various stresses and pathological stimuli, podocytes are prone to injuries; moreover, as a cell without proliferative potential, loss of ...
C. Lu, G. Wang, Jian Lu, Pei-pei Chen, Yang Zhang, Z. Hu, K. Ma   +6 more
semanticscholar   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond

Cells
Podocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico, Sandra Merscher, Alessia Fornoni   +2 more
doaj   +1 more source

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF‐κB Signaling

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose‐deficient IgA1 (Gd‐IgA1) and renal inflammation.
Meng‐Si Li, Kai Liu
wiley   +1 more source

CD36-Mediated Lipid Accumulation and Activation of NLRP3 Inflammasome Lead to Podocyte Injury in Obesity-Related Glomerulopathy

Mediators of Inflammation, 2019
Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury.
Jing Zhao, Hong-liang Rui, Min Yang, Li-jun Sun, Hong-rui Dong, Hong Cheng   +5 more
doaj   +1 more source