Results 111 to 120 of about 41,440 (279)

Tmem30a protects against podocyte injury through suppression of pyroptosis

iScience
Summary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou, Sipei Chen, Lei Peng, Liming Huang, Huijian Zhang, Ping Zhang, Min Yu, Lin Xiong, Xiang Zhong, Wenjing Liu, Xianjun Zhu, Li Wang, Yi Li, Guisen Li   +13 more
doaj   +1 more source

Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases

The Journal of Clinical Investigation, 2023
The progression of proteinuric kidney diseases is associated with podocyte loss, but the mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to repair double-stranded DNA breaks.
Xuefei Tian, Christopher E. Pedigo, Ke Li, Xiaotao Ma, Patricia Bunda, John Pell, Angela Lek, Jianlei Gu, Yan Zhang, Paulina X. Medina Rangel, Wei Li, Eike Schwartze, Soichiro Nagata, Gabriel Lerner, Sudhir Perincheri, Anupama Priyadarshini, Hongyu Zhao, Monkol Lek, Madhav C. Menon, Rongguo Fu, Shuta Ishibe   +20 more
doaj   +1 more source

Systematic Deciphering of ATBC Nephrotoxicity Mechanisms via Machine Learning and Single‐Cell Analysis

Medicine Bulletin, EarlyView.
This study elucidates the nephrotoxic mechanism of acetyl tributyl citrate (ATBC) by integrating network toxicology, machine learning, and single‑cell multi‑omics analysis to systematically decipher the molecular mechanisms and cell‑type‑specific regulatory networks underlying ATBC‑induced kidney injury. First, a protein‑protein interaction network was
Yimao Wu, Yalun Liang, Jintao Liang, Wenlong Sun, Qian Zhang, Meng‐Yao Li   +5 more
wiley   +1 more source

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2:Implications for podocyte depletion and proteinuria in diabetes mellitus [PDF]

, 2015
Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). N-carboxymethyl-lysine (CML) is one of the predominant AGEs that accumulate in all renal compartments of diabetic patients.
Kumar, P Anil, Menon, Ram K, Raghu, G, Reddy, G Bhanuprakash, Saleem, Moin A, Welsh, Gavin I   +5 more
core   +2 more sources

Development of a Novel Diagnostic Test Using Podocyturia as a Biomarker for Detection of Kidney Damage [PDF]

, 2013
Primary glomerular diseases are the most common cause of progressive chronic kidney disease (CKD) in dogs, a common and significant source of illness that often progresses to kidney failure.
Farooqi, Eesha
core   +1 more source

Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses

Cell Reports
Summary: Signal-regulatory protein alpha (SIRPα) has recently been found to be highly expressed in podocytes and is essential for maintaining podocyte function. However, its immunoregulatory function in podocytes remains elusive.
Bin Qian, Rui Lu, Shuya Mao, Yang Chen, Miao Yang, Wenxuan Zhang, Mingchao Zhang, Dihan Zhu, Zhihong Liu, Ke Zen, Limin Li   +10 more
doaj   +1 more source

ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling [PDF]

, 2013
Nephrotic syndrome (NS) is divided into steroid-sensitive (SSNS) and -resistant (SRNS) variants. SRNS causes end-stage kidney disease, which cannot be cured.
Antignac, Bodo B. Beck, Bugsu Ovunc, Christian Faul, Corinne Antignac, Dominik S. Schoeb, Edgar A. Otto, Friedhelm Hildebrandt, Gil Chernin, Hanan M. Fathy, Heike Goebel, Heon Yung Gee, Hildebrandt, Humphrey Fang, Jeffrey W. Innis, Joseph Washburn, Julia Hoefele, Katrina A. Diaz, Lutz T. Weber, Neveen A. Soliman, Olivier Gribouval, Pawaree Saisawat, Roger C. Wiggins, Saleem, Shawn Levy, Shazia Ashraf, Sivakumar Natarajan, Svjetlana Lovric, Toby W. Hurd, Virginia Vega-Warner, Weibin Zhou, Wong, Yaacov Frishberg, Zhe Han   +33 more
core   +2 more sources

Multimodal Assessment of Kidney Quality During 24‐h of Normothermic Machine Perfusion

Artificial Organs, EarlyView.
Normothermic machine perfusion (NMP) has emerged as a promising tool for assessing kidney quality prior to transplantation; however, reliable biomarkers remain to be established. In this study, thirteen porcine kidneys were perfused for 24 h using an autologous leukocyte‐filtered whole blood‐based perfusate applying urine recirculation.
Marlene Pühringer, Magdalena Kött, Andras T. Meszaros, Michael J. Blumer, Bettina Zelger, Stefan Redl, Martin Hermann, Thomas Resch, Simon Mathis, Gabriel Putzer, Judith Martini, Christina Bogensperger, Franka Messner, Julia Hofmann, Margot Fodor, Andrea Griesmacher, Annemarie Weissenbacher, Theresa Hautz, Gert Mayer, Hannes Neuwirt, Gerald Brandacher, Silvia Oberparleiter, Stefan Schneeberger   +22 more
wiley   +1 more source

Under the right conditions: protecting podocytes from diabetes-induced damage [PDF]

, 2013
Hyperglycemia-induced damage to the glomerular podocyte is thought to be a critical early event in diabetic nephropathy. Interventions that prevent podocyte damage or loss have been shown to have potential for the treatment of diabetic nephropathy.
Ali, Imran HA, Brazil, Derek P.
core   +1 more source

Podocyte Differentiation and Glomerulogenesis [PDF]

Journal of the American Society of Nephrology, 2003
This review will concentrate on the assembly of the glomerulus and the differentiation of the podocyte during that process. The differentiation of the vascular component of the glomerulus will not be emphasized, as it has been the subject of several recent reviews ([1][1]–[4][2]), except ...
openaire   +2 more sources