Results 111 to 120 of about 47,897 (254)

Forsythoside A Alleviates High Glucose-Induced Oxidative Stress and Inflammation in Podocytes by Inactivating MAPK Signaling via MMP12 Inhibition

, 2021
Xiaohong Quan, Huihui Liu, Dongmei Ye, Xinling Ding, Xiulan Su   +4 more
openalex   +2 more sources

CD36 and Its Role in Obesity

Obesity Reviews, EarlyView.
ABSTRACT Obesity is understood as a condition driven by interactions between genetics and environmental factors. The role of CD36 in the regulation of lipid metabolism and ectopic fat accumulation emerges as a key area of interest. This review presents CD36 not only as a crucial facilitator of fatty acid uptake but also as a regulator of how and where ...
Nahuel Garcia, Maiken Mellergaard, Carlos Salomon, Pilar Sepulveda, Peter Kristensen, Aase Handberg   +5 more
wiley   +1 more source

mTOR blockade prevents progressive proteinuria but induces hyperglycaemia in obese Dahl salt‐sensitive rats before puberty

Experimental Physiology, EarlyView.
Abstract Previous studies have demonstrated that mammalian target of rapamycin (mTOR) activity is significantly increased in the kidneys of Dahl salt‐sensitive (SS) rats during the development of renal injury. Therefore, in the present study we examined whether blockade of mTOR with rapamycin inhibits renal injury in Dahl salt‐sensitive leptin receptor
Sautan Mandal, Andrea K. Brown, Ubong S. Ekperikpe, Anukool A. Bhopatkar, Krystle M. Hughes, Tyler D. Johnson, Jonita S. Cooper, Konnor T. Wilbert, Denise C. Cornelius, Jan M. Williams   +9 more
wiley   +1 more source

Tmem30a protects against podocyte injury through suppression of pyroptosis

iScience
Summary: Podocytopathies, such as focal segmental glomerulosclerosis (FSGS), are characterized by podocyte injury and can easily progress to end-stage kidney disease. However, the mechanisms underlying podocyte injury remain unclear. We observed podocyte
Yanpei Hou, Sipei Chen, Lei Peng, Liming Huang, Huijian Zhang, Ping Zhang, Min Yu, Lin Xiong, Xiang Zhong, Wenjing Liu, Xianjun Zhu, Li Wang, Yi Li, Guisen Li   +13 more
doaj   +1 more source

The calcium-sensing receptor as a regulator of cellular fate in normal and pathological conditions [PDF]

, 2013
The calcium-sensing receptor (CaSR) belongs to the evolutionarily conserved family of plasma membrane G protein-coupled receptors (GPCRs). Early studies identified an essential role for the CaSR in systemic calcium homeostasis through its ability to ...
Benoit, Yves, D'Herde, Katharina, Diez Fraile, Araceli, Lammens, Tim   +3 more
core   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

Experimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu, Xuan Gang, Jingjing Wang, Guoping Huang, Qiuyu Li, Weizhong Gu, Haidong Fu, Jianhua Mao   +7 more
wiley   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, Volume 46, Issue 1, Page 149-175, January 2026.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

Podocytes in health and glomerular disease

Frontiers in Cell and Developmental Biology
Podocytes are highly specialized, terminally differentiated cells in the glomerulus of the kidney and these cells play a central role in blood filtration.
Joanna Cunanan, Joanna Cunanan, Joanna Cunanan, Daniel Zhang, Daniel Zhang, Daniel Zhang, Anna Julie Peired, Moumita Barua, Moumita Barua, Moumita Barua   +9 more
doaj   +1 more source

Nicotine Induces Podocyte Apoptosis through Increasing Oxidative Stress.

PLoS ONE, 2016
BackgroundCigarette smoking plays an important role in the progression of chronic kidney disease (CKD). Nicotine, one of the major components of cigarette smoking, has been demonstrated to increase proliferation of renal mesangial cells.
Xiqian Lan, Rivka Lederman, Judith M Eng, Seyedeh Shadafarin Marashi Shoshtari, Moin A Saleem, Ashwani Malhotra, Pravin C Singhal   +6 more
doaj   +1 more source