Results 111 to 120 of about 47,146 (309)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) is associated with morbidity and mortality. Ferroptosis is associated with the pathophysiology of SA‐AKI. Here, we investigated the role of LIM and cysteine‐rich domain 1 (LMCD1) in the regulation of ferroptosis during SA‐AKI progression.
You‐Qi Zhang +5 more
wiley +1 more source
Profilin1 is required for prevention of mitotic catastrophe in murine and human glomerular diseases
The Journal of Clinical Investigation, 2023 The progression of proteinuric kidney diseases is associated with podocyte loss, but the mechanisms underlying this process remain unclear. Podocytes reenter the cell cycle to repair double-stranded DNA breaks.
Xuefei Tian +20 more
doaj +1 more source
Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]
, 2018 The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Asfahani, R +10 more
core
Innate Immune Activity in Glomerular Podocytes [PDF]
, 2017 Glomerular podocytes are specialized in structure and play an essential role in glomerular filtration. In addition, podocyte stress can initiate glomerular damage by inducing the injury of other glomerular cell types.
Hong Xia, Shaolin Shi, Wenduona Bao
core +1 more source
P4‐ATPases as Phospholipid Flippases: From Membrane Dynamics to Human Disorders
Medicine Bulletin, EarlyView.ABSTRACT P4‐ATPases (P4 subfamily of P‐type ATPases) flippase complex includes an α‐subunit responsible for catalysis and a supporting β‐subunit, which consumes energy by catalyzing the hydrolysis of ATP, thereby facilitating the translocation of aminophospholipids from the outer to the inner leaflet of cellular membranes to maintain the asymmetric ...
Guangyi Chen, Yeming Yang, Xianjun Zhu
wiley +1 more source
Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond
CellsPodocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico +2 more
doaj +1 more source
Podocyte Differentiation and Glomerulogenesis [PDF]
Journal of the American Society of Nephrology, 2003 This review will concentrate on the assembly of the glomerulus and the differentiation of the podocyte during that process. The differentiation of the vascular component of the glomerulus will not be emphasized, as it has been the subject of several recent reviews ([1][1]–[4][2]), except ...
openaire +3 more sources
Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges
Medicinal Research Reviews, EarlyView.ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca +2 more
wiley +1 more source
Research advances on the role of ubiquitin proteasome in podocyte injury of diabetic kidney disease
Linchuang shenzangbing zazhiDiabetic kidney disease (DKD) is a disease of abnormal renal structure and function due to long-term hyperglycemia. Podocyte injury is a major cause of renal inflammation, glomerular filtration barrier injury and renal fibrosis.
Jin Wang, Wen-ling Dai, Ji-hua Liu
doaj +1 more source
Diabetic Nephropathy: Perspective on Novel Molecular Mechanisms [PDF]
, 2016 Diabetes mellitus (DM) is the major cause of end-stage renal disease (ESRD) globally, and novel treatments are urgently needed. Current therapeutic approaches for diabetic nephropathy (DN) are focussing on blood pressure control with inhibitors of the ...
Coward, RJ, Gnudi, L, Long, DA
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