Results 131 to 140 of about 48,174 (296)

The protective effect and mechanism of catalpol on high glucose-induced podocyte injury [PDF]

, 2019
Yan Chen, Qingpu Liu, Zengfu Shan, Yingying Zhao, Meng Li, Baiyan Wang, Xiaoke Zheng, Weisheng Feng   +7 more
openalex   +1 more source

Effect of empagliflozin on urinary albumin excretion and hypoxic biomarkers in early diabetic kidney disease: A randomised double‐blind, placebo‐controlled trial

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims The precise mechanism of sodium glucose co‐transporter 2 (SGLT2) inhibitor on reno‐protective effect has been still unclear. In this study, we hypothesised that SGLT2 inhibitor prevents diabetic kidney disease via reduction of hypoxia‐induced factors.
Hisashi Makino, Masato Kasahara, Ryuzo Takashima, Shu Kasama, Naoki Ozu, Hyohun Park, Qingxing Chen, Kazuhiko Tsuruya, Mayu Tochiya, Yoko Omura‐Ohata, Tamiko Tamanaha, Michio Noguchi, Takeshi Aiba, Fumiki Yoshihara, Kiminori Hosoda   +14 more
wiley   +1 more source

Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses

Cell Reports
Summary: Signal-regulatory protein alpha (SIRPα) has recently been found to be highly expressed in podocytes and is essential for maintaining podocyte function. However, its immunoregulatory function in podocytes remains elusive.
Bin Qian, Rui Lu, Shuya Mao, Yang Chen, Miao Yang, Wenxuan Zhang, Mingchao Zhang, Dihan Zhu, Zhihong Liu, Ke Zen, Limin Li   +10 more
doaj   +1 more source

SGLT2 inhibitor dapagliflozin limits podocyte damage in proteinuric nondiabetic nephropathy.

JCI Insight, 2018
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have pleiotropic properties beyond blood glucose-lowering effects and modify important nonglycemic pathways, leading to end-organ protection.
P. Cassis, M. Locatelli, Domenico Cerullo, D. Corna, Simona Buelli, Cristina Zanchi, Sebastian Villa, M. Morigi, G. Remuzzi, A. Benigni, C. Zoja   +10 more
semanticscholar   +1 more source

Non-canonical NFκB activation promotes chemokine expression in podocytes [PDF]

, 2016
Lara Valiño‐Rivas, Laura González‐Lafuente, Ana B. Sanz, Marta Ruiz‐Ortega, Alberto Ortíz, María Dolores Sánchez-Niño   +5 more
openalex   +1 more source

The Krüppel-like factor 15-NFATc1 axis ameliorates podocyte injury: a novel rationale for using glucocorticoids in proteinuria diseases [PDF]

, 2020
Caoshuai Dou, Hong Zhang, Guibao Ke, Li Zhang, Zhiwen Lian, Xueqin Chen, Xingchen Zhao, Yuanhan Chen, Ruizhao Li, Jianchao Ma, Zhuo Li, Ting Lin, Wenjian Wang, Zhi ming Ye, Xinling Liang, Wei Shi, Bin Zhang, Shuangxin Liu   +17 more
openalex   +1 more source

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source

POS-397 Severe diabetic glomerulosclerosis by chronic hypoxic housing of db/db mice; the role of mesangiolysis and podocyte injury with ultrastructural abnormalities

, 2021
Naoki Takahashi, Hiromu Yoshida, Hideki Kimura, Kazuko Kamiyama, Tomomi Kurose, H Sugimoto, Toshio Imura, S. Yokoi, Kenji Kasuno, Hiroyuki Kurosawa, Y. Hirayama, Hironobu Naiki, Masanori Hara, Masayuki Iwano   +13 more
openalex   +1 more source

Remnant cholesterol/high‐density lipoprotein cholesterol ratio is a new powerful tool for identifying diabetic kidney disease

Journal of Diabetes Investigation, EarlyView.
Remnant cholesterol to high‐density lipoprotein cholesterol ratio exhibits a positive association with the risk of diabetic kidney disease. ABSTRACT Background Remnant cholesterol to high‐density lipoprotein cholesterol ratio (RHR) has been identified as a reliable predictor for metabolic disease risk.
Jiale Zhang, Shuping Zhou, Haojie Zhang, Jiang Liu   +3 more
wiley   +1 more source