Results 151 to 160 of about 31,106 (252)
Nephrology, Volume 31, Issue 8, August 2026.ABSTRACT A 69‐year‐old male patient presented with weight loss and proteinuria. His medical history included papillary thyroid carcinoma. Laboratory findings showed proteinuria and high κ light chain levels in both urine and serum. Bone marrow aspiration revealed plasma cell myeloma of the IgA‐κ type.
Seoyoung Choi, Kyung Chul Moon
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Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis. [PDF]
Natriuretic peptides (NPs) bind to glomerular podocytes and attenuate glomerular injury. The beneficial effects of NPs are negatively regulated by the NP clearance receptor (NPRC), which is highly expressed in podocytes.
Anne F Buckley +3 more
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Persistent Haematuria Is Associated With Reduced Kidney Survival in Primary Podocytopathies
Nephrology, Volume 31, Issue 8, August 2026.ABSTRACT Aim Haematuria is frequently present in podocytopathies, but its significance and prognostic value are not well described. This study aimed to determine the prevalence and association between persistent haematuria and kidney survival in patients with membranous nephropathy (MN), minimal change disease (MCD) and focal segmental ...
Gabriel Ștefan +3 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.The Graphical Abstract demonstrates our research approach. Use GEO database to screen differentially expressed genes (DEGs), and weighted gene co expression network analysis (WGCNA) to identify ubiquitination related gene modules. The LASSO logistic regression and support vector machine recursive feature elimination (SVM‐RFE) algorithm is used to ...
Ting Dong +4 more
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New Ways of Thinking about Proteinuria and Progression of Renal Damage [PDF]
, 2010 Zhou, Y. S., Turner, Neil
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The FASEB Journal, Volume 40, Issue 14, 31 July 2026.Hyperglycemia upregulates CTRP1 and SGLT2 in renal tubular cells, promoting glucose influx, CTRP1‐mediated glucotoxic stress, and tubular senescence in diabetic kidney disease. In the experimental model, SGLT2 inhibition with dapagliflozin was associated with reduced glucose uptake, attenuation of tubular senescence, suppression of CTRP1‐related ...
Lina Gu +6 more
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Urinary podocyte markers in diabetic kidney disease [PDF]
Podocytes are involved in maintaining kidney function and are a major focus of research on diabetic kidney disease (DKD). Urinary biomarkers derived from podocyte fragments and molecules have been proposed for the diagnosis and monitoring of DKD. Various
Cheuk-Chun Szeto, Chuanlei Li
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The FASEB Journal, Volume 40, Issue 13, 15 July 2026.YAP1 mediates tubular cell senescence and drives maladaptive repair following AKI, promoting the AKI to CKD transition. Single‐cell RNA‐seq reveals sustained YAP1 overexpression, fibroblast activation, and pro‐fibrotic tubular cell shift. Senolytic agents or verteporfin (YAP1/TEAD1 inhibitor) suppress YAP1 activity, reduce renal senescence, alleviate ...
Zhibo Zhao +7 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang +4 more
wiley +1 more source
Podocyte injury damages podocytes in chimeric organoids
Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenitor cells of two mouse lines: one expressing a receptor for a ...
Tomohiro Udagawa +3 more
openaire +1 more source