Aging Cell, Volume 25, Issue 2, February 2026.Using in vitro DNA damage assays in human T cells, ex vivo profiling of aged immune subsets and a small placebo‐controlled in vivo study, authors show that low‐dose rapamycin, a potent life‐extending mTOR inhibitor, enhances resilience against DNA damage in the human immune system.
Loren Kell +8 more
wiley +1 more source
Podocyte hypertrophic stress and detachment precedes hyperglycemia or albuminuria in a rat model of obesity and type2 diabetes-associated nephropathy [PDF]
, 2019 Akihiro Minakawa +6 more
openalex +1 more source
The biology of PKM2 in the metabolism and senescence in diabetic kidney disease
Journal of Diabetes Investigation, Volume 17, Issue 2, Page 197-204, February 2026.ABSTRACT Diabetic kidney disease (DKD) is one of the most common causes of chronic kidney disease that leads to end‐stage kidney disease, and its progression is closely linked to metabolic stress within renal tubular cells. Under long‐term hyperglycemia, cells shift their glucose metabolism from normal oxidative phosphorylation toward glycolysis.
Md. Imrul Kayes, Keizo Kanasaki
wiley +1 more source
[Podocyte dysfunction and proteinuria].
Nederlands tijdschrift voor geneeskunde, 2004 Podocytes play a central role in the pathogenesis of several glomerular diseases. In recent years, this has been revealed by molecular analysis of a number of rare hereditary renal diseases. Podocytes contain three domains: the domain bound to the glomerular basement membrane (GBM), the domain of the slit diaphragms and the apical domain.
Vogtländer, N.P.J. +3 more
openaire +3 more sources
Cardio-renal Effect of Dapagliflozin AND Dapagliflozin- Saxagliptin combination on CD34+ve Hematopoietic Stem Cells (HSCs) and Podocyte specific markers in Type 2 Diabetes (T2DM) subjects: a randomized trial. [PDF]
Seshagiri Rao Nandula +2 more
openalex +1 more source
Fluvastatin protects against puromycin aminonucleoside-induced podocyte injury by inhibiting TRPC6
, 2022 openalex +1 more source
Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation
, 2002 Jeffrey H. Miner +6 more
openalex +2 more sources
MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes [PDF]
, 2015 Junnan Wu +11 more
openalex +1 more source