Results 211 to 220 of about 31,106 (252)
Targeting LRH-1 alleviates diabetes-induced lipotoxicity in podocytes: role of PLIN5-mediated lipid droplet turnover. [PDF]
Ren FailGuan Q +8 more
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RAB27A silencing modulates miR-30d-5p expression and extracellular vesicle non-coding RNA cargo in diabetic podocytes. [PDF]
Sci RepMartinez-Arroyo O +10 more
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Current Opinion in Nephrology and Hypertension, 2009 The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets.
Mathieson, PW
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Kidney International, 2022
Podocytes undergo defined morphologic changes during development, homeostasis, and aging, and on injury. Quantitative podometric assessments of podocyte endowment provide a powerful tool to interrogate glomerular health. Expanding this approach to a regional assessment demonstrates that the podocytes from cortical, subcortical, and juxtamedullary ...
Stuart J, Shankland, Oliver, Wessely
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Podocytes undergo defined morphologic changes during development, homeostasis, and aging, and on injury. Quantitative podometric assessments of podocyte endowment provide a powerful tool to interrogate glomerular health. Expanding this approach to a regional assessment demonstrates that the podocytes from cortical, subcortical, and juxtamedullary ...
Stuart J, Shankland, Oliver, Wessely
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Podocyte progenitors and ectopic podocytes
Nature Reviews Nephrology, 2013Two types of parietal podocyte were previously described in the Bowman capsule: one characterized by coexpression of podocyte and parietal epithelial cell markers, the other characterized by expression of podocyte markers only. New research demonstrates that these populations represent podocyte progenitors and ectopic podocytes—distinct cell types with
Laura Lasagni, Paola Romagnani
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Roles of the podocyte in glomerular function [PDF]
American Journal of Physiology - Renal Physiology, 2000 The podocyte is the most differentiated cell type in the glomerulum, which forms a crucial component of the glomerular filtration barrier. It has been assumed that podocyte foot processes counteract the elastic force of the glomerular basement membrane ...
H Pavenstädt
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Current Opinion in Rheumatology, 2019
Purpose of review Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus and is characterized by proteinuria and renal failure. Proteinuria is a marker of poor prognosis and is attributed to podocyte loss and dysfunction. It is often debated whether these cells are innocent bystanders or
Rhea, Bhargava, George C, Tsokos
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Purpose of review Lupus nephritis (LN) is a serious manifestation of systemic lupus erythematosus and is characterized by proteinuria and renal failure. Proteinuria is a marker of poor prognosis and is attributed to podocyte loss and dysfunction. It is often debated whether these cells are innocent bystanders or
Rhea, Bhargava, George C, Tsokos
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From placenta to podocyte: vascular and podocyte pathophysiology in preeclampsia
Clinical Nephrology, 2012Preeclampsia is a disorder of hypertension and proteinuria that affects 6 - 8% of normal pregnancies. Recent research has revealed many molecular mechanisms that may contribute to systemic endothelial dysfunction, glomerular capillary endotheliosis, dysregulation of the glomerular filtration apparatus, and podocyte loss. An ischemic placenta elaborates
Steven J, Wagner +3 more
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Nephron Experimental Nephrology, 2006
Cytoskeletal dynamics play important roles during normal podocyte development, in maintenance of the healthy glomerular filter, and in glomerular pathology. During the past few years, essential progress has been made in understanding the molecular mechanisms that govern podocyte cytoskeletal dynamics, nevertheless this knowledge remains incomplete ...
Marcus J, Moeller, Lawrence B, Holzman
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Cytoskeletal dynamics play important roles during normal podocyte development, in maintenance of the healthy glomerular filter, and in glomerular pathology. During the past few years, essential progress has been made in understanding the molecular mechanisms that govern podocyte cytoskeletal dynamics, nevertheless this knowledge remains incomplete ...
Marcus J, Moeller, Lawrence B, Holzman
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