Results 301 to 310 of about 64,667 (338)
Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy
Journal of Diabetes Research, 2017 Diabetic nephropathy (DN) together with glomerular hyperfiltration has been implicated in the development of diabetic microangiopathy in the initial stage of diabetic diseases.
Qingquan Liu, Baoli Liu
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From placenta to podocyte: vascular and podocyte pathophysiology in preeclampsia
Clinical Nephrology, 2012Preeclampsia is a disorder of hypertension and proteinuria that affects 6 - 8% of normal pregnancies. Recent research has revealed many molecular mechanisms that may contribute to systemic endothelial dysfunction, glomerular capillary endotheliosis, dysregulation of the glomerular filtration apparatus, and podocyte loss. An ischemic placenta elaborates
Steven J, Wagner +3 more
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Current Opinion in Nephrology and Hypertension, 2009
The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets.
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The podocyte is a key cell in the selective filtering action of the glomerular capillary wall. Podocyte injury is of pathogenetic and prognostic significance in human glomerular disease; podocyte repair and regeneration are important therapeutic targets.
openaire +4 more sources
Nephron Experimental Nephrology, 2006
Cytoskeletal dynamics play important roles during normal podocyte development, in maintenance of the healthy glomerular filter, and in glomerular pathology. During the past few years, essential progress has been made in understanding the molecular mechanisms that govern podocyte cytoskeletal dynamics, nevertheless this knowledge remains incomplete ...
Marcus J, Moeller, Lawrence B, Holzman
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Cytoskeletal dynamics play important roles during normal podocyte development, in maintenance of the healthy glomerular filter, and in glomerular pathology. During the past few years, essential progress has been made in understanding the molecular mechanisms that govern podocyte cytoskeletal dynamics, nevertheless this knowledge remains incomplete ...
Marcus J, Moeller, Lawrence B, Holzman
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Experimental and Molecular Medicine, 2019 The number of patients with diabetic nephropathy (DN) is still on the rise worldwide, and this requires the development of new therapeutic strategies. Recent reports have highlighted genetic factors in the treatment of DN.
Dongwei Liu +7 more
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Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function
Nature Communications, 2019 Albuminuria affects millions of people, and is an independent risk factor for kidney failure, cardiovascular morbidity and death. The key cell that prevents albuminuria is the terminally differentiated glomerular podocyte. Here we report the evolutionary
Liang-Fong Wong +2 more
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Current Medicinal Chemistry, 2008
Recent advances have identified the podocyte as a key target in glomerular injury. The podocyte is a highly specialized cell which is responsible for the glomerular permselectivity for proteins in the kidney. Podocyte injury or loss leads to proteinuria. Apoptosis has been shown to contribute to renal cell loss, including loss of podocytes.
Juan Antonio, Moreno +8 more
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Recent advances have identified the podocyte as a key target in glomerular injury. The podocyte is a highly specialized cell which is responsible for the glomerular permselectivity for proteins in the kidney. Podocyte injury or loss leads to proteinuria. Apoptosis has been shown to contribute to renal cell loss, including loss of podocytes.
Juan Antonio, Moreno +8 more
openaire +2 more sources
The role of the podocyte in glomerulosclerosis
Current Opinion in Nephrology and Hypertension, 1999Focal segmental glomerulosclerosis is a pathological hallmark of many forms of progressive renal disease. The 'classic' lesion, based on the adhesion of the capillary tuft to Bowman's capsule, results from the loss of podocytes from the capillary basement membrane.
W, Kriz, K V, Lemley
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Current Opinion in Nephrology and Hypertension, 2001
Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
K, Endlich, W, Kriz, R, Witzgall
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Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a ...
K, Endlich, W, Kriz, R, Witzgall
openaire +2 more sources
Journal of Cellular Physiology, 2018
Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development of diabetic nephropathy (DN).
Tao Zhang +6 more
semanticscholar +1 more source
Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development of diabetic nephropathy (DN).
Tao Zhang +6 more
semanticscholar +1 more source