Results 101 to 110 of about 50,846 (317)

Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes [PDF]

, 2015
Increased plasma level of soluble urokinase-type plasminogen activator receptor (suPAR) was associated recently with focal segmental glomerulosclerosis (FSGS).
Alfano, Massimo, Cinque, Paola, Giusti, Guido, Proietti, Silvia, Nebuloni, Manuela, Danese, Silvio, D'Alessio, Silvia, Genua, Marco, Portale, Federica, Lo Porto, Manuela, Singhal, Pravin C, Rastaldi, Maria Pia, Saleem, Moin A, Mavilio, Domenico, Mikulak, Joanna   +14 more
core   +2 more sources

P4‐ATPases as Phospholipid Flippases: From Membrane Dynamics to Human Disorders

Medicine Bulletin, EarlyView.
ABSTRACT P4‐ATPases (P4 subfamily of P‐type ATPases) flippase complex includes an α‐subunit responsible for catalysis and a supporting β‐subunit, which consumes energy by catalyzing the hydrolysis of ATP, thereby facilitating the translocation of aminophospholipids from the outer to the inner leaflet of cellular membranes to maintain the asymmetric ...
Guangyi Chen, Yeming Yang, Xianjun Zhu
wiley   +1 more source

Aberrant Glycosylation of IgG in Children With Active Lupus Nephritis Alters Podocyte Metabolism and Causes Podocyte Injury. [PDF]

Arthritis Rheumatol
Objective Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes, and decreased nephrin production.
Bhargava R, Upadhyay R, Zhao C, Katakam P, Wenderfer S, Chen J, He H, Cummings R, Tsokos MG, Tsokos GC.   +9 more
europepmc   +2 more sources

Differential Expression Of Gap Junction mRNAs And Proteins In The Developing Murine Kidney And In Experimentally Induced Nephric Mesenchymes [PDF]

, 1992
The expression of three gap junction (GJ) proteins, alpha-1 (Cx43), beta-1 (Cx32), and beta-2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney. These proteins were expressed in two non-overlapping patterns.
Gilbert, Scott F., Gilula, N. B., Kumar, N. M., Lehtonen, E., Nishi, M., Sainio, K., Saxen, L.   +6 more
core   +1 more source

Innate Immune Activity in Glomerular Podocytes [PDF]

, 2017
Glomerular podocytes are specialized in structure and play an essential role in glomerular filtration. In addition, podocyte stress can initiate glomerular damage by inducing the injury of other glomerular cell types.
Hong Xia, Shaolin Shi, Wenduona Bao
core   +1 more source

Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges

Medicinal Research Reviews, EarlyView.
ABSTRACT Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation.
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti   +2 more
wiley   +1 more source

C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation [PDF]

, 2019
Hypertrophy is a prominent feature of damaged podocytes in diabetic kidney disease (DKD). mTORC1 hyperactivation leads to podocyte hypertrophy, but the detailed mechanism of how mTORC1 activation occurs under pathological conditions is not completely ...
Ha, Tae-Sun, Jeong, Heeyoon, Kim, Eui, Koh, Ara, Lee, Jiyoun, Ryu, Sung Ho, Saleem, Moin A.   +6 more
core   +1 more source

Calcium sensing in podocytes [PDF]

Kidney International, 2011
Besides its primary function in maintaining systemic calcium homeostasis, the calcium-sensing receptor (CaSR) is expressed by many cell types, with different, sometimes opposite, regulatory functions. Novel work from Oh and collaborators shows that activation of CaSR in podocytes has prosurvival effects and protects the cell from puromycin ...
openaire   +3 more sources

Fibroblast‐specific palladin drives kidney fibrosis via MRTF–SRF signaling

The Journal of Pathology, EarlyView.
Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts.
Naoki Yamamoto, Norihiko Sakai, Yuta Yamamura, Daichi Kaikoi, Daiki Hayashi, Takahiro Matsuno, Akihiko Koshino, Keisuke Sako, Keisuke Horikoshi, Takahiro Yuasa, Akira Tamai, Taichiro Minami, Megumi Oshima, Shiori Nakagawa, Shinji Kitajima, Akinori Hara, Miho Shimizu, Jumpei Terakawa, Shin‐ichi Horike, Takiko Daikoku, Atsushi Mizokami, Hiroko Ikeda, Moeno Kadoguchi, Hiroshi Arakawa, Sumio Ohtsuki, David Lagares, Takashi Wada, Yasunori Iwata   +27 more
wiley   +1 more source

Insulin Increases Expression of TRPC6 Channels in Podocytes by a Calcineurin-Dependent Pathway

Cellular Physiology and Biochemistry, 2016
Background/Aims: Insulin signaling to podocytes is relevant for the function of the glomerulus. Now, we tested the hypothesis that insulin increases the surface expression of canonical transient receptor potential canonical type 6 (TRPC6) channels in ...
Shengqiang Xia, Ying Liu, Xinming Li, Florian Thilo, Martin Tepel   +4 more
doaj   +1 more source