Results 101 to 110 of about 68,048 (352)

A Review of Podocyte Biology [PDF]

American Journal of Nephrology, 2018
<b><i>Background:</i></b> Podocyte biology is a developing science that promises to help improve understanding of the mechanistic nature of multiple diseases associated with proteinuria. Proteinuria in nephrotic syndrome has been linked to mechanistic dysfunctions in the renal glomerulus involving the function of podocyte ...
openaire   +2 more sources

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Inhibition of SGLT2 protects podocytes in diabetic kidney disease by rebalancing mitochondria-associated endoplasmic reticulum membranes

Cell Communication and Signaling
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors have changed the therapeutic landscape for diabetic kidney disease (DKD) patients, but their underlying mechanisms are complicated and not fully understood.
Xuehong Li, Qiong Li, Xinying Jiang, Shicong Song, Wei Zou, Qinglan Yang, Sirui Liu, Shuangqin Chen, Cheng Wang   +8 more
doaj   +1 more source

Autophagy downregulation contributes to insulin resistance mediated injury in insulin receptor knockout podocytes in vitro [PDF]

PeerJ, 2016
It is unknown whether autophagy activity is altered in insulin resistant podocytes and whether autophagy could be a therapeutic target for diabetic nephropathy (DN).
Ying Xu, Qi Zhou, Wei Xin, Zhaoping Li, Liyong Chen, Qiang Wan   +5 more
doaj   +2 more sources

Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]

, 2010
Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim, Sayyed, Sufyan Ali, Vielhauer, Volker   +2 more
core   +1 more source

Yishen capsule promotes podocyte autophagy through regulating SIRT1/NF-κB signaling pathway to improve diabetic nephropathy [PDF]

, 2021
Yuxiang Liu, Wenyuan Liu, Ziyuan Zhang, Yaling Hu, Xiaodong Zhang, Sun Yanyan, Qingqing Lei, Dalin Sun, Ting Liu, Yanjun Fan, Hui Li, Wujie Ding, Jingai Fang   +12 more
openalex   +1 more source

Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

Journal of Pathology, 2018
Insufficient autophagy in podocytes is related to podocyte injury in diabetic nephropathy (DN). Advanced glycation end‐products (AGEs) are major factors of podocyte injury in DN.
Xingchen Zhao, Yuan-han Chen, Xiaofan Tan, Li Zhang, Hong Zhang, Zhilian Li, Shuangxin Liu, Rui-zhao Li, Ting Lin, Ruyi Liao, Qianmei Zhang, W. Dong, W. Shi, Xinling Liang   +13 more
semanticscholar   +1 more source

Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing

Advanced Science, EarlyView.
Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley   +1 more source

Activation of the Nrf2-ARE Pathway Ameliorates Hyperglycemia-Mediated Mitochondrial Dysfunction in Podocytes Partly Through Sirt1

Cellular Physiology and Biochemistry, 2018
Background/Aims: Previously we have shown that activation of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-antioxidant response element (ARE) attenuated hyperglycemia-induced damage in podocytes, but the molecular mechanism remains unknown ...
Qunzi Zhang, Qiongxia Deng, Jun Zhang, JianTing Ke, Ye Zhu, Ruo wei Wen, Zengchun Ye, Hui Peng, Zhong zhen Su, Cheng Wang, Tanqi Lou   +10 more
doaj   +1 more source

Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy

Drug Design, Development and Therapy, 2018
Background Endoplasmic reticulum stress is associated with podocyte apoptosis in the pathogenesis of diabetic nephropathy (DN). A previous study has demonstrated that emodin has a protective effect in the kidney by suppressing proliferation of mesangial ...
Nianxiu Tian, Yanbin Gao, Xiaolei Wang, Xiao-ming Wu, Dawei Zou, Zhiyao Zhu, Zheji Han, Tao Wang, Yimin Shi   +8 more
semanticscholar   +1 more source