Results 111 to 120 of about 27,144 (229)
Diabetic kidney disease, biomarkers, and finerenone
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2582-2593, April 2026.Abstract Diabetic kidney disease (DKD), the leading cause of kidney failure worldwide, is associated with an increased risk of cardiovascular disease (CVD). A complex pathobiology involving hemodynamic, metabolic, and immune dysregulation promotes inflammatory and fibrotic pathways that contribute to kidney disease progression and CVD in individuals ...
Ashish Verma, Ashish Upadhyay
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Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 2978-2987, April 2026.Abstract Aims The precise mechanism of sodium glucose co‐transporter 2 (SGLT2) inhibitor on reno‐protective effect has been still unclear. In this study, we hypothesised that SGLT2 inhibitor prevents diabetic kidney disease via reduction of hypoxia‐induced factors.
Hisashi Makino +14 more
wiley +1 more source
[Podocyte dysfunction and proteinuria].
Nederlands tijdschrift voor geneeskunde, 2004 Podocytes play a central role in the pathogenesis of several glomerular diseases. In recent years, this has been revealed by molecular analysis of a number of rare hereditary renal diseases. Podocytes contain three domains: the domain bound to the glomerular basement membrane (GBM), the domain of the slit diaphragms and the apical domain.
Vogtländer, N.P.J. +3 more
openaire +3 more sources
Journal of Internal Medicine, Volume 299, Issue 4, Page 444-466, April 2026.Abstract Increased urinary albumin excretion is a strong predictor for cardiovascular events in persons with and without decreased glomerular filtration rate and can be assessed with the urinary albumin‐to‐creatinine ratio (UACR), which is a selective, sensitive, and convenient method for patients.
Holly J. Kramer, George L. Bakris
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The FASEB Journal, Volume 40, Issue 6, 31 March 2026.This graphical abstract illustrates an integrative analysis of single‐cell RNA‐seq data in CKD. DEGs were subsequently identified as candidate genes via Mendelian randomization analysis and combined with MAGMA analysis, ITCH was identified as a key gene.
Xia Zhang +7 more
wiley +1 more source
Biomarkers of Lupus Nephritis Histopathology: Where Do We Stand?
Arthritis &Rheumatology, Volume 78, Issue 3, Page 548-557, March 2026.Objective Lupus nephritis (LN) is characterized by a variable disease course, necessitating continuous monitoring. There is an urgent need to identify noninvasive biomarkers. By reviewing and critically assessing the quality of existing studies on LN biomarkers correlating with histopathology, we here explore the challenges in promoting their use in ...
Valentina Querin +11 more
wiley +1 more source
Arthritis &Rheumatology, Volume 78, Issue 3, Page 654-664, March 2026.Objective Glucagon‐like peptide 1 receptor agonists (GLP‐1RAs) and sodium‐glucose cotransporter 2 inhibitors (SGLT2i) facilitate weight loss and exhibit immunomodulatory effects, but their impact on the risk of developing autoimmune rheumatic diseases (ARDs) is unclear.
Derin Karacabeyli +4 more
wiley +1 more source
The renal response to FGF23 shifts from phosphaturia toward inflammation in kidney disease
Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.Abstract FGF23 excess is associated with morbidity and mortality, but the role of excessive circulating FGF23 concentrations as a causative factor of pathology is controversial. Here, we investigated the consequences of FGF23 excess in kidney disease. This study used three disease models: anti‐glomerular basement membrane (anti‐GBM) disease, Adriamycin
Matthias B. Moor +10 more
wiley +1 more source