Results 111 to 120 of about 50,846 (317)

Nrf2‐Mediated Ferroptosis Is Involved in Berberine‐Induced Alleviation of Diabetic Kidney Disease

Phytotherapy Research, EarlyView.
ABSTRACT Diabetic kidney disease (DKD) is the most common and serious complication of diabetes mellitus. Currently, there is a lack of safe and effective preventive strategies for DKD. The study aimed to explore the preventive effects and potential mechanisms of berberine (BBR) against DKD.
Kun Gao, Yunhua Liu, Kun Li, Lin Liu, Yanmo Cai, Xinxue Zhang, Zongjiang Zhao   +6 more
wiley   +1 more source

Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes

Journal of Diabetes Research, 2020
Tangshen Formula (TSF) is a Chinese Medicine formula that has been reported to alleviate proteinuria and protect renal function in humans and animals with diabetic kidney disease (DKD).
Qian Wang, Xuefei Tian, Wei’e Zhou, Yan Wang, Hailing Zhao, Jialin Li, Xuefeng Zhou, Haojun Zhang, Tingting Zhao, Ping Li   +9 more
doaj   +1 more source

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction [PDF]

, 2017
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are limited. To identify novel therapeutic strategies, we studied protective factors for DN using proteomics on glomeruli from ...
Amenta, Peter S, Burkart, Alison M, Cahill, Christopher, Coppey, Lawrence J, Feener, Edward P, Hastings, Stephanie, Ishikado, Atsushi, Israelsen, William J, Kannt, Aimo, Keenan, Hillary A, King, George L, Li, Qian, Liew, Chong Wee, Lockhart, Samuel, Niewczas, Monika A, Pfenninger, Anja, Pober, David, Qi, Weier, Qiang, Guifen, Sadowski, Thorsten, Stanton, Robert C, Stillman, Isaac E, Tinsley, Liane, Vander Heiden, Matthew G., Wu, I-Hsien, Yorek, Mark A   +25 more
core   +1 more source

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

A Compendium of Urinary Biomarkers Indicative of Glomerular Podocytopathy [PDF]

, 2013
It is well known that glomerular podocyte injury and loss are present in numerous nephropathies and that the pathophysiologic consecution of disease hinges upon the fate of the podocyte.
Pichler Sekulic, Simona, Sekulic, Miroslav   +1 more
core   +2 more sources

Podocyte Differentiation and Glomerulogenesis [PDF]

Journal of the American Society of Nephrology, 2003
This review will concentrate on the assembly of the glomerulus and the differentiation of the podocyte during that process. The differentiation of the vascular component of the glomerulus will not be emphasized, as it has been the subject of several recent reviews ([1][1]–[4][2]), except ...
openaire   +3 more sources

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells

Frontiers in Immunology, 2018
Calcium calmodulin kinase IV (CaMK4) regulates multiple processes that significantly contribute to the lupus-related pathology by controlling the production of IL-2 and IL-17 by T cells, the proliferation of mesangial cells, and the function and ...
Andrew P. Ferretti, Rhea Bhargava, Shani Dahan, Maria G. Tsokos, George C. Tsokos   +4 more
doaj   +1 more source

Alterations of podocytes in a murine model of crescentic glomerulonephritis [PDF]

, 2018
Recent observations suggest a central role of podocytes in crescent formation. In experimental glomerulonephritis podocytes disrupt the parietal epithelial layer and attach on its basement membrane, thus forming bridges between the tuft and Bowman's ...
Besse-Eschmann, Valérie, Endlich, Karlhans, Endlich, Nicole, Le Hir, Michel   +3 more
core  

Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]

, 2018
BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina, Chiappini, Elena, Dalzini, Annalisa, De Rossi, Anita, Galli, Luisa, Giaquinto, Carlo, Petrara, Maria Raffaella   +6 more
core   +1 more source