Results 181 to 190 of about 68,048 (352)
Fibroblast‐specific palladin drives kidney fibrosis via MRTF–SRF signaling
The Journal of Pathology, Volume 268, Issue 1, Page 40-53, January 2026.Abstract Fibrosis is a common end‐stage pathway of progressive chronic kidney diseases. Previously we demonstrated that myocardin‐related transcription factor (MRTF)–serum response factor (SRF) signaling drives the expression of fibrosis‐related molecules through actin cytoskeleton dynamics in renal fibroblasts.
Naoki Yamamoto +27 more
wiley +1 more source
Activation of podocyte Notch mediates early Wt1 glomerulopathy [PDF]
, 2018 The Wilms' tumor suppressor gene, WT1, encodes a zinc finger protein that regulates podocyte development and is highly expressed in mature podocytes. Mutations in the WT1 gene are associated with the development of renal failure due to the formation of ...
Asfahani, R +10 more
core
Tetrandrine Attenuates Podocyte Injury by Inhibiting TRPC6-Mediated RhoA/ROCK1 Pathway [PDF]
, 2022 Lichan Mao +4 more
openalex +1 more source
The FASEB Journal, Volume 39, Issue 24, 31 December 2025.We investigated two models of mitochondrial dysfunction in podocytes, using two cell culture models: podocytes isolated from mice with Oma1 deletion (Oma1del) and mouse podocytes modified with an inducible knockdown of PHB2 (Phb2kd). OMA1 deficiency induced a glycolytic shift, enhanced glutamine anaplerosis, and sustained energy homeostasis after ...
Cem Özel +13 more
wiley +1 more source
Isolation of Podocyte Cell Fractions From Mouse Kidney Using Magnetic Activated Cell Sorting (MACS)
Bio-ProtocolGlomerular diseases characterized by injury to post-mitotic epithelial cells called podocytes are a leading cause of chronic kidney disease. Yet, isolating podocytes from the kidney for transcriptomic, proteomic, and metabolomic studies has been a major ...
Jeffrey Pippin +4 more
doaj +1 more source
Amplification of the Melanocortin-1 Receptor in Nephrotic Syndrome Identifies a Target for Podocyte Cytoskeleton Stabilization [PDF]
, 2018 Lovisa Bergwall +10 more
openalex +1 more source
Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis
Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han +7 more
wiley +1 more source
Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.A simplified, co‐culture‐free protocol for kidney organoids that generate segmented nephrons, including collecting ducts, has been developed. Early low‐dose RA with FGF9 induces balanced anterior–posterior IM patterning and dual UE/MM lineage commitment. BMP7 enhances nephron progenitor maturation.
Jung Hwa Lim +13 more
wiley +1 more source