Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?
European Journal of Histochemistry, 2015 The association between podoplanin and ezrin in the process of odontogenic tumors invasion has been suggested, but was not studied yet. Our purpose was to investigate the relationship between podoplanin and ezrin expressions in the odontogenic epithelium
Y.F. Costa +5 more
doaj +1 more source
Transplantation of embryonic spleen tissue reveals a role for adult non-lymphoid cells in initiating lymphoid tissue organization [PDF]
, 2009 In this report we describe a transplantation system where embryonic spleens are grafted into adult hosts. This model can be used to analyze the cellular and molecular requirements for the development and organization of splenic microenvironments.Whole ...
Aloisi +43 more
core +2 more sources
New trends in the study of podoplanin as a cell morphological regulator
Japanese Dental Science Review, 2010 Podoplanin is a mucin-type glycoprotein firstly identified in podocytes, which is homologous to the type I alveolar cell specific T1α-2 antigen and to the oncofetal antigen M2A recognized by the D2-40 antibody. Podoplanin possesses a platelet aggregation-
Yoshihiko Sawa
doaj +1 more source
Indian Journal of Dental Sciences, 2021 Background: Odontogenic lesions can bring about diagnostic challenges due to overlapping histology among pathologists. Thus, there are few tumor markers that provide accurate diagnosis.
Alka Chahar +4 more
doaj +1 more source
Platelet CLEC2-Podoplanin Axis as a Promising Target for Oral Cancer Treatment
Frontiers in Immunology, 2021 Cancer tissues are not just simple masses of malignant cells, but rather complex and heterogeneous collections of cellular and even non-cellular components, such as endothelial cells, stromal cells, immune cells, and collagens, referred to as tumor ...
Byeong-Oh Hwang +8 more
semanticscholar +1 more source
Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis [PDF]
, 2011 BACKGROUND Mechanisms regulating breast cancer lymph node metastasis are unclear. Staining of CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor-1) in human breast tumors was used, along with in vitro techniques, to assess ...
Ammar, Aula +6 more
core +3 more sources
Podoplanin expression in the development and progression of laryngeal squamous cell carcinomas
Molecular Cancer, 2010 Background Podoplanin expression is attracting interest as a marker for cancer diagnosis and prognosis. We therefore investigated the expression pattern and clinical significance of podoplanin during the development and progression of laryngeal ...
Fresno Manuel F +5 more
doaj +1 more source
Syk-dependent Phosphorylation of CLEC-2: A Novel Mechanism of Hem-Immunoreceptor Tyrosine-Based Activation Motif Signaling [PDF]
, 2010 The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM).
Eble, J. A. +7 more
core +2 more sources
Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation
Scientific Reports, 2017 Podoplanin/Aggrus, known as a platelet aggregation-inducing factor, is frequently overexpressed in lung squamous cell carcinomas (LSCC) and glioblastomas among other tumours, and its expression has been reported to be correlated with poor prognosis ...
Kenichi Miyata +4 more
doaj +1 more source
Physiological and pathophysiological aspects of blood platelet activation through CLEC-2 receptor
Онкогематология, 2018 Platelet activating receptor CLEC-2 has been identified on platelet surface a decade ago. The only confirmed endogenous CLEC-2 agonist is podoplanin. Podoplanin is a transmembrane protein expressed by lymphatic endothelial cells, reticular fibroblastic ...
A. A. Martyanov +3 more
doaj +1 more source