Results 61 to 70 of about 13,097 (241)

The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis

BMC Cancer
Podoplanin (PDPN) expressed on tumour cells interacts with platelet C-type lectin-like receptor 2 (CLEC-2). This study aimed to investigate the role of the PDPN-platelet CLEC-2 interaction in melanoma pulmonary metastasis.
Minjia Sheng, Ran Sun, Jianxin Fu, Gao Lu   +3 more
semanticscholar   +1 more source

Podoplanin as a predictive marker for identification of high-risk mycosis fungoides patients: An immunohistochemical study

Indian Journal of Dermatology, 2020
Background: Podoplanin, an important protein, has been implicated in various cellular processes, including lymphangiogenesis. Podoplanin is a mucin-type transmembrane glycoprotein that is accepted as a novel marker of lymphatic endothelial cells ...
Amal A El-Ashmawy, Maha M Shamloula, Nashwa N Elfar   +2 more
doaj   +1 more source

Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin

Cells, 2020
Malignant pleural mesothelioma (MPM) has extremely limited treatment despite a poor prognosis. Moreover, molecular targeted therapy for MPM has not yet been implemented; thus, a new targeted therapy is highly desirable.
Yuko Nishinaga, Kazuhide Sato, H. Yasui, S. Taki, Kazuomi Takahashi, Misae Shimizu, Rena Endo, Chiaki Koike, Noriko Kuramoto, S. Nakamura, T. Fukui, H. Yukawa, Y. Baba, Mika K. Kaneko, T. Chen-Yoshikawa, Hisataka Kobayashi, Y. Kato, Y. Hasegawa   +17 more
semanticscholar   +1 more source

Prognostic value of podoplanin expression in intratumoral stroma and neoplastic cells of uterine cervical carcinomas

Clinics, 2010
OBJECTIVE: To investigate the clinicopathological significance of podoplanin expression in the intratumoral stroma and neoplastic cells of early stage uterine cervical cancer.
Filomena M Carvalho, Fabricia L Zaganelli, Bernardo G L Almeida, Joao Carlos Sampaio Goes, Edmund C Baracat, Jesus P Carvalho   +5 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The multifaceted role of podoplanin expression in hepatocellular carcinoma

European Journal of Histochemistry, 2017
The role of podoplanin in hepatocellular carcinoma (HCC) is not clear yet. The aim of our study was to evaluate the expression of podoplanin in HCC and to determine its role in hepatocarcinogenesis. We performed immunohistochemistry with monoclonal D2-40
Andreea Cioca, Amalia R. Ceausu, Irina Marin, Marius Raica, Anca M. Cimpean   +4 more
doaj   +1 more source

A Sacrificial 3D Printed Vessel‐on‐Chip Demonstrates a Versatile Approach to Model Granulation Tissue

Advanced Healthcare Materials, EarlyView.
A novel method that combines 3D printing and organ‐on‐chip technology enables the creation of hollow channels lined with endothelial cells through a fibroblast‐populated connective tissue matrix. The model supports stable metabolic culture conditions, angiogenic sprouting, and immune cell migration, thereby demonstrating an easy and versatile method to
Jonas Jäger, Phil Berger, Andrew I. Morrison, Hendrik Erfurth, Maria Thon, Eva‐Maria Dehne, Susan Gibbs, Jasper J. Koning   +7 more
wiley   +1 more source

The landscape of ‘podoplanin’ in dermatology

Journal of the Egyptian Women's Dermatologic Society, 2021
Podoplanin (PDPN) is a specific marker for lymphatic endothelial cells; however, it can be expressed by many other cells including renal podocytes. In dermatology, PDPN has been involved in diverse disorders, such as tumor lymphangiogenesis, as well as in immune-mediated disorders.
Nagwa Diab, Magda Assaf, Nourhan Anis, Eman Salah   +3 more
openaire   +2 more sources

Podoplanin is a useful prognostic marker and indicates better differentiation in lung squamous cell cancer patients? A systematic review and meta-analysis

BMC Cancer, 2020
Background The CSC (cancer stem cell) markers often indicate poor prognosis and more cell invasion or migration of cancer patients. Podoplanin was assumed as a candidate CSC marker and predict poor prognosis among squamous cancers.
Liya Hu, Peng Zhang, Qi Mei, Wei Sun, Lei Zhou, Tiejun Yin   +5 more
doaj   +1 more source