Results 71 to 80 of about 13,097 (241)

Microphysiological Systems of Lymphatics and Immune Organs

Advanced Healthcare Materials, EarlyView.
This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain, Ankur Singh, Andrés J. García   +2 more
wiley   +1 more source

Podoplanin Drives Dedifferentiation and Amoeboid Invasion of Melanoma [PDF]

SSRN Electronic Journal, 2020
Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilise amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology and high actomyosin contractility driven by the RhoA signalling pathway.
Charlotte M. de Winde, Samantha L. George, Abbey B. Arp, Agnesska C. Benjamin, Eva Crosas-Molist, Yukti Hari-Gupta, Alexander Carver, Valerio Imperatore, Victor G. Martinez, Victoria Sanz-Moreno, Sophie E. Acton   +10 more
openaire   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

Evaluation of Podoplanin in Oral Leukoplakia and Oral Squamous Cell Carcinoma

Scientifica, 2015
Background. Recent studies have demonstrated that podoplanin was expressed in some dysplastic lesions adjacent to primary oral cancers suggesting that podoplanin expression may occur in early oral tumorigenesis and lymphangiogenesis and therefore is ...
Ashok Patil, Kishor Patil, Suyog Tupsakhare, Mahesh Gabhane, Shrikant Sonune, Shilpa Kandalgaonkar   +5 more
doaj   +1 more source

Novel Combination of Surface Markers for the Reliable and Comprehensive Identification of Human Thymic Epithelial Cells by Flow Cytometry: Quantitation and Transcriptional Characterization of Thymic Stroma in a Pediatric Cohort

Frontiers in Immunology, 2021
Thymic epithelial cells (TECs) are essential in supporting the development of mature T cells from hematopoietic progenitor cells and facilitate their lineage-commitment, proliferation, T-cell receptor repertoire selection and maturation.
Veronika Haunerdinger, Maria Domenica Moccia, Lennart Opitz, Stefano Vavassori, Hitendu Dave, Mathias M. Hauri-Hohl   +5 more
doaj   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

ET-6 EFFICACY OF NEAR-INFRARED PHOTOIMMUNOTHERAPY TARGETING PODOPLANIN IN MALIGNANT GLIOMAS [PDF]

, 2022
Manabu Natsumeda, Jotaro On, Jun Watanabe, Kazuhiro Ando, Yoshihiro Tsukamoto, Masayasu Okada, Ryosuke Ogura, Makoto Oishi, Yukihiko Fujii   +8 more
openalex   +1 more source

Human Podoplanin-positive Monocytes and Platelets Enhance Lymphangiogenesis Through the Activation of the Podoplanin/CLEC-2 Axis [PDF]

Molecular Therapy, 2014
Emerging studies suggested that murine podoplanin-positive monocytes (PPMs) are involved in lymphangiogenesis. The goal of this study was to demonstrate the therapeutic lymphangiogenesis of human PPMs by the interaction with platelets. Aggregation culture of human peripheral blood mononuclear cells (PBMCs) resulted in cellular aggregates termed ...
Hur, Jin, Jang, Jae Hee, Oh, Il-Young, Choi, Jae-Il, Yun, Ji-Yeon, Kim, Joonoh, Choi, Young-Eun, Ko, Seung-Bum, Kang, Jin-A, Kang, Jeehoon, Lee, Sang Eun, Lee, Hwan, Park, Young-Bae, Kim, Hyo-Soo   +13 more
openaire   +2 more sources

Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2

Retrovirology, 2010
Background Platelets are associated with HIV in the blood of infected individuals and might modulate viral dissemination, particularly if the virus is directly transmitted into the bloodstream.
Münch Jan, Schmökel Jan, Kato Yukinari, Glowacka Ilona, Bertram Stephanie, Tsegaye Theodros, Steffen Imke, Chaipan Chawaree, Simmons Graham, Gerardy-Schahn Rita, Pöhlmann Stefan   +10 more
doaj   +1 more source

CLEC-2 Prevents Accumulation and Retention of Inflammatory Macrophages During Murine Peritonitis

Frontiers in Immunology, 2021
Platelets play a key role in the development, progression and resolution of the inflammatory response during sterile inflammation and infection, although the mechanism is not well understood.
Joshua H. Bourne, Nonantzin Beristain-Covarrubias, Malou Zuidscherwoude, Malou Zuidscherwoude, Joana Campos, Ying Di, Evelyn Garlick, Evelyn Garlick, Martina Colicchia, Lauren V. Terry, Steven G. Thomas, Steven G. Thomas, Alexander Brill, Alexander Brill, Jagadeesh Bayry, Jagadeesh Bayry, Steve P. Watson, Steve P. Watson, Julie Rayes, Julie Rayes   +19 more
doaj   +1 more source