Results 71 to 80 of about 19,338 (290)

Podoplanin-positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion [PDF]

, 2014
Podoplanin (PDPN) is a well established lymphatic endothelial marker and has frequently been observed in cancer cells at the edge of cancer masses. Previous studies investigating the association between PDPN expression and patient prognosis have had ...
Ai, JY, Chen, K, Fu, L, Guan, X, Li, JC, Li, Y, Qin, YR, Wang, LJ, Zhu, YH   +8 more
core   +1 more source

Serum Level of Podoplanin in Vitiligo [PDF]

Benha Journal of Applied Sciences, 2020
The natural part of podoplanin is still inadequately comprehended. With respect to critical part of cell–cell connections in supportive of incendiary cytokine creation, a component stayed to be recognized. The aim of the present study was to evaluate serum level of Podoplanin in patients with vitiligo and assessment of its clinical significance.
A.I. Mustafa, F.M. El-Esawy, W.A. Abdul Haleem, O.R. Al-Hayali   +3 more
openaire   +2 more sources

Cancer-associated fibroblasts expressing fibroblast activation protein and podoplanin in non-small cell lung cancer predict poor clinical outcome

British Journal of Cancer
Background Cancer-associated fibroblasts (CAFs) are a dominant cell type in the stroma of non-small cell lung cancer (NSCLC). Fibroblast heterogeneity reflects subpopulations of CAFs, which can influence prognosis and treatment efficacy.
Layla Mathieson, Lilian Koppensteiner, David A. Dorward, Richard A O'Connor, A. Akram   +4 more
semanticscholar   +1 more source

The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis

BMC Cancer
Background Podoplanin (PDPN) expressed on tumour cells interacts with platelet C-type lectin-like receptor 2 (CLEC-2). This study aimed to investigate the role of the PDPN-platelet CLEC-2 interaction in melanoma pulmonary metastasis.
Minjia Sheng, Ran Sun, Jianxin Fu, Gao Lu   +3 more
semanticscholar   +1 more source

Platelets and cancer-associated thrombosis: focusing on the platelet activation receptor CLEC-2 and podoplanin.

Blood, 2019
Patients with cancer have an increased risk of thromboembolism, which is the second leading cause of death in these patients. Several mechanisms of the prothrombotic state in these patients have been proposed.
K. Suzuki-Inoue
semanticscholar   +1 more source

Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early Rheumatoid Arthritis: an observational study. [PDF]

, 2015
INTRODUCTION: Neovascularization contributes to the development of sustained synovial inflammation in the early stages of Rheumatoid Arthritis. Ultrasound (US) provides an indirect method of assessing synovial blood flow and has been shown to correlate ...
AE Koch, AE Koch, Alessandra Marrelli, Arti Mahto, AW Mould, Costantino Pitzalis, Debasish Pyne, E Bodolay, Frances Humby, J Holash, J Holash, K Polzer, Lu Zou, M Andersen, M Raica, M Walther, M Walther, Maria DiCicco, Michele Bombardieri, Nora Ng, P Haiko, PP Tak, Rebecca E Hands, S Kelly, S Lee, Stephen Kelly, Sudeh Riahi, U Fiocco, U Fiocco, V Krenn, WA Schmidt, Y Jing, Y Xu, Z Szekanecz   +33 more
core   +2 more sources

Podoplanin-Fc burns out platelets [PDF]

Blood, 2010
In this issue of Blood, Cueni and colleagues have demonstrated that podoplanin-Fc not only displays an inhibitory effect on lymphatic vessel formation, but also induces platelet aggregation and disseminated intravascular coagulation (DIC) in transgenic mice.
Kim, HS Kim, Hon-Soul, Koh, GY Koh, Gou-Young   +1 more
openaire   +4 more sources

Podoplanin as a predictive marker for identification of high-risk mycosis fungoides patients: An immunohistochemical study

Indian Journal of Dermatology, 2020
Background: Podoplanin, an important protein, has been implicated in various cellular processes, including lymphangiogenesis. Podoplanin is a mucin-type transmembrane glycoprotein that is accepted as a novel marker of lymphatic endothelial cells ...
Amal A El-Ashmawy, Maha M Shamloula, Nashwa N Elfar   +2 more
doaj   +1 more source

Neutral solution low in glucose degradation products is associated with less peritoneal fibrosis and vascular sclerosis in patients receiving peritoneal dialysis. [PDF]

, 2012
BACKGROUND: The effects of novel biocompatible peritoneal dialysis (PD) solutions on human peritoneal membrane pathology have yet to be determined. Quantitative evaluation of human peritoneal biopsy specimens may reveal the effects of the new solutions ...
HONDA Kazuho, KAWANISHI Kunio, NITTA Kosaku, ODA Hideaki, TSUKADA Misao   +4 more
core   +2 more sources

Podoplanin as an Attractive Target of CAR T Cell Therapy [PDF]

Cells, 2020
To date, various kinds of cancer immunotherapy methods have been developed, but T cell immunotherapy is one of the most promising strategies. In general, T cell receptor (TCR) or chimeric antigen receptor (CAR) is used to modify the antigen specificity of T cells.
Masazumi Waseda, Shin Kaneko
openaire   +3 more sources