Results 31 to 40 of about 1,268,660 (340)
Effects of local mutations in quadratic iterations [PDF]
, 2020 We introduce mutations in replication systems, in which the intact copying mechanism is performed by discrete iterations of a complex quadratic map. More specifically, we consider a "correct" function acting on the complex plane (representing the space ...
Longbotham, Abraham, Radulescu, Anca R
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DNA polymerase α (swi7) and the flap endonuclease fen1 (rad2) act together in the s-phase alkylation damage response in S. pombe [PDF]
, 2012 Polymerase α is an essential enzyme mainly mediating Okazaki fragment synthesis during lagging strand replication. A specific point mutation in Schizosaccharomyces pombe polymerase α named swi7-1, abolishes imprinting required for mating-type switching ...
Jacob Z. Dalgaard +5 more
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Point Mutation Rate of Bacteriophage ΦX174 [PDF]
Genetics, 2009 Abstract The point mutation rate of phage ΦX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0 × 10−6 substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per round of copying ...
Cuevas, José M. +2 more
openaire +3 more sources
Genetic Correlations in Mutation Processes
, 1998 We study the role of phylogenetic trees on correlations in mutation processes. Generally, correlations decay exponentially with the generation number. We find that two distinct regimes of behavior exist.
A. S. Lapedes +11 more
core +1 more source
An Activating Mutation in sos-1 Identifies Its Dbl Domain as a Critical Inhibitor of the Epidermal Growth Factor Receptor Pathway during Caenorhabditis elegans Vulval Development [PDF]
, 2007 Proper regulation of receptor tyrosine kinase (RTK)-Ras-mitogen-activated protein kinase (MAPK) signaling pathways is critical for normal development and the prevention of cancer.
Elgort, Marc G. +7 more
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Proteins’ Evolution upon Point Mutations
ACS Omega, 2022 The primary aim of this work is to explore how proteins point mutations impact their marginal stability and, hence, their evolvability. With this purpose, we show that the use of four classic notions, namely, those from Leibniz & Kant (1768), Maynard Smith (1970), Einstein & Infeld (1961), and Anfinsen (1973), is sufficient for a better ...
openaire +3 more sources
Frontiers in Plant Science, 2020 AtAMT1;3 is a major contributor to high-affinity ammonium uptake in Arabidopsis roots. Using a stable electrophysiological recording strategy, we demonstrate in Xenopus laevis oocytes that AtAMT1;3 functions as a typical high-affinity NH4+ uniporter ...
Dong-Li Hao +7 more
doaj +1 more source
L925I mutation in the Para-type sodium channel is associated with pyrethroid resistance in Triatoma infestans from the Gran Chaco region [PDF]
, 2014 Background: Chagas' disease is an important public health concern in Latin America. Despite intensive vector control efforts using pyrethroid insecticides, the elimination of Triatoma infestans has failed in the Gran Chaco, an ecoregion that extends over
Capriotti, Natalia +3 more
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Cancer Medicine, 2020 Emergence of clones carrying point mutations in the BCR‐ABL1 kinase domain (KD) is a common mechanism of resistance to tyrosine kinase inhibitor (TKI)‐based therapies in Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL).
Simona Soverini +13 more
doaj +1 more source
Structurally constrained protein evolution: results from a lattice simulation
, 2000 We simulate the evolution of a protein-like sequence subject to point mutations, imposing conservation of the ground state, thermodynamic stability and fast folding. Our model is aimed at describing neutral evolution of natural proteins.
Bastolla, Ugo +2 more
core +1 more source