Results 31 to 40 of about 6,585,062 (339)
STRUM: structure-based prediction of protein stability changes upon single-point mutation
Bioinform., 2016 MOTIVATION Mutations in human genome are mainly through single nucleotide polymorphism, some of which can affect stability and function of proteins, causing human diseases.
Lijun Quan, Q. Lv, Yang Zhang
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Helical ambivalency induced by point mutations [PDF]
BMC Structural Biology, 2013 Mutation of amino acid sequences in a protein may have diverse effects on its structure and function. Point mutations of even a single amino acid residue in the helices of the non-redundant database may lead to sequentially identical peptides which adopt different secondary structures in different proteins.
Parbati Biswas, Nicholus Bhattacharjee
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Insects, 2020 The two-spotted spider mite Tetranychus urticae is a difficult-to-control pest due to its short life cycle and rapid resistance development. In this study, we characterized field strains collected in 2001 and 2003 that were selected for acequinocyl ...
Jihye Choi +5 more
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Effects of Point Mutations on the Activity of AcrB [PDF]
Biophysical Journal, 2012 The tripartite efflux pump AcrAB-TolC is responsible for the intrinsic and acquired multidrug resistance in Escherichia coli. Its active part, the homotrimeric transporter AcrB, is in charge of the selective binding of substrates and energy transduction.The presence of several phenilalanine residues in the only binding pocket identified by X-ray has ...
RUGGERONE, PAOLO +2 more
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Frontiers in Molecular Neuroscience, 2018 Defining functional domains and amino acid residues in G protein coupled receptors (GPCRs) represent an important way to improve rational drug design for this major class of drug targets.
Melanie Wickert +11 more
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Antimicrobial Agents and Chemotherapy, 2017 We have identified the first case of an fks1 hot spot 1 point mutation causing echinocandin resistance in a clinical Aspergillus fumigatus isolate recovered from a chronic pulmonary aspergillosis patient with an aspergilloma who first failed azole and ...
Cristina Jimenez-Ortigosa +3 more
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Structural effects of point mutations in proteins [PDF]
Proteins: Structure, Function, and Bioinformatics, 2018 AbstractA structural database of 11 families of chains differing by a single amino acid substitution has been built. Another structural dataset of 5 families with identical sequences has been used for comparison. The RMSD computed after a global superimposition of the mutated protein on each native one is smaller than the RMSD calculated among proteins
Shanthirabalan, Suvethigaa +2 more
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A novel human pain insensitivity disorder caused by a point mutation in ZFHX2
Brain : a journal of neurology, 2017 Studies of monogenic heritable pain disorders provide valuable insights into human pain mechanisms. Habib et al. show that a point mutation in the gene ZFHX2 causes an autosomal dominant form of pain insensitivity.
A. Habib +32 more
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Proteins’ Evolution upon Point Mutations
ACS Omega, 2022 The primary aim of this work is to explore how proteins point mutations impact their marginal stability and, hence, their evolvability. With this purpose, we show that the use of four classic notions, namely, those from Leibniz & Kant (1768), Maynard Smith (1970), Einstein & Infeld (1961), and Anfinsen (1973), is sufficient for a better ...
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Elastin genetic point mutation and the risk of pelvic organ prolapse
Clinical and Experimental Obstetrics & Gynecology, 2020 Aim: A missense mutation in the elastin gene (g28197A > G) is associated with an increased risk for inguinal hernias. Due to the shared epidemiological and pathophysiological features between pelvic organ prolapse (POP) and inguinal hernias, the authors ...
N. Haya +5 more
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