Results 41 to 50 of about 7,351,528 (349)

Structurally constrained protein evolution: results from a lattice simulation

, 2000
We simulate the evolution of a protein-like sequence subject to point mutations, imposing conservation of the ground state, thermodynamic stability and fast folding. Our model is aimed at describing neutral evolution of natural proteins.
Bastolla, Ugo, Roman, H. Eduardo, Vendruscolo, Michele   +2 more
core   +1 more source

Two Point Mutations on CYP51 Combined With Induced Expression of the Target Gene Appeared to Mediate Pyrisoxazole Resistance in Botrytis cinerea

Frontiers in Microbiology, 2020
Botrytis cinerea is a destructive plant pathogenic ascomycete that causes serious pre- and post-harvest losses worldwide. The novel sterol 14α-demethylase inhibitor (DMI) pyrisoxazole was recently registered for the control of tomato gray mold caused by ...
Can Zhang, Muhammad Imran, Min Liu, Zhiwen Li, Huige Gao, Hongxia Duan, Shunli Zhou, Xili Liu   +7 more
doaj   +1 more source

On Exceptional Times for generalized Fleming-Viot Processes with Mutations

, 2013
If $\mathbf Y$ is a standard Fleming-Viot process with constant mutation rate (in the infinitely many sites model) then it is well known that for each $t>0$ the measure $\mathbf Y_t$ is purely atomic with infinitely many atoms.
B Schmuland, DA Dawson, DA Dawson, Donnelly, EB Dynkin, J Berestycki, J Bertoin, J Bertoin, J Bertoin, J Jacod, J Lamperti, J Pitman, J Pitman, LA Shepp, M Birkner, M Birkner, M Birkner, N Berestyck, N Ikeda, N Konno, P Donnelly, SN Ethier, SN Ethier, T Duquesne, TG Kurtz, WH Fleming, Z Fu, Z Li, Z Li   +28 more
core   +2 more sources

Intrachromosomal Amplification, Locus Deletion and Point Mutation in the Aquaglyceroporin AQP1 Gene in Antimony Resistant Leishmania (Viannia) guyanensis

PLoS Neglected Tropical Diseases, 2015
Background Antimony resistance complicates the treatment of infections caused by the parasite Leishmania. Methodology/Principal Findings Using next generation sequencing, we sequenced the genome of four independent Leishmania guyanensis antimony ...
R. Monte-Neto, Marie-Claude N. Laffitte, P. Leprohon, P. Reis, F. Frézard, M. Ouellette   +5 more
semanticscholar   +1 more source

QUANTITATIVE RHOA Gly17Val ALLELE-SPECIFIC POLYMERASE CHAIN REACTION AND T-CELL CLONALITY ANALYSIS IN ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA

Онкогематология, 2018
Introduction. Аngioimmunoblastic T-cell lymphoma (AITL) is a T-cell lymphoma, characterized by abundant polymorphocellular infiltrate of lymph nodes with the small number of tumor CD4+ T-cells.
Yu. V. Sidorova, N. G. Chernova, I. A. Yakutik, S. Yu. Smirnova, N. V. Ryzhikova, E. E. Nikulina, M. Yu. Aleksenko, M. N. Sinitsyna, A. M. Kovrigina, T. N. Moiseeva, E. E. Zvonkov, A. B. Sudarikov   +11 more
doaj   +1 more source

Genetic analysis of NS5B gene from bovine viral diarrhea virus-infected cattle in Central and East Java, Indonesia [PDF]

Veterinary World, 2019
Background and Aim: A previous study divided Indonesian bovine viral diarrhea virus (BVDV)-1 into subgenotypes BVDV-1a to BVDV-1d based on the partial NS5B gene using strain Bega as reference for BVDV-1a. In fact, it is clustered into BVDV-1c with strain
S. H. Irianingsih, H. Wuryastuty, R. Wasito, H. Wibawa, F. S. Tjatur Rasa, B. Poermadjaja   +5 more
doaj   +1 more source

A Magnetoelectrochemical Bioassay for Highly Sensitive Sensing of Point Mutations in Interleukin-6 Gene Using TMB as a Hybridization Intercalation Indicator

Biosensors, 2023
Point mutations are common in the human DNA genome and are closely related to higher susceptibility to cancer diseases. Therefore, suitable methods for their sensing are of general interest.
Sabrine Baachaoui, Mohamed Mastouri, Maroua Meftah, Basma Yaacoubi-Loueslati, Noureddine Raouafi   +4 more
doaj   +1 more source

A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]

, 1994
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Bahn, Rebecca S., Dutton, Charyl M., Heufelder, Armin E., Sarkar, Gobinda   +3 more
core   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Site-directed mutagenesis of cysteine to serine residues affects heparin binding and mitogenicity in fibroblast growth factor 4 produced in Escherichia coli

Biotechnology & Biotechnological Equipment, 2019
The binding activity to heparan sulphate is crucial for the mitogenic activity of fibroblast growth factor 4 (FGF4) in developing mammalian embryos. There are two conserved cysteine residues in FGF family proteins, Cys-84 and Cys-151 in mouse FGF4, and ...
Yuki Kumagai, Takahiro Kikuchi, Asumi Nonaka, Misuzu Hiraide, Suguru Sato, Mizuki Sakuraoka, Akira Sasaki, Masayuki Kobayashi   +7 more
doaj   +1 more source