Antiviral activity of ribosome-inactivating proteins [PDF]
, 2021 Producción CientíficaRibosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis.
Citores González, Lucía +2 more
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Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site [PDF]
, 2007 Maize ribosome-inactivating protein is classified as a class III or an atypical RNA N-glycosidase. It is synthesized as an inactive precursor with a 25-amino acid internal inactivation region, which is removed in the active form.
Amanda Nga-Sze Mak +40 more
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Suppression of human T-cell leukemia virus I gene expression by pokeweed antiviral protein. [PDF]
J Biol Chem, 2009 Human T-cell leukemia virus I (HTLV-I) is a deltaretrovirus that is the causative agent of adult T-cell leukemia and the neurological disorder HTLV-I-associated myelopathy/tropical spastic paraparesis. Currently, no effective antiretroviral treatment options are available to restrict the development of diseases associated with the virus.
Mansouri S +4 more
europepmc +4 more sources
Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina [PDF]
, 2013 Ribosome-inactivating proteins (RIPs) are endowed with several medicinal properties, including antiviral activity. We demonstrate here that the recently identified type I RIP from Momordica balsamina also possesses antiviral activity, as determined by ...
Ahmed, Zahra +5 more
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The pokeweed leaf mRNA transcriptome and its regulation by jasmonic acid.
Frontiers in Plant Science, 2016 The American pokeweed plant, Phytolacca americana, is recognized for synthesizing pokeweed antiviral protein (PAP), a ribosome inactivating protein (RIP) that inhibits the replication of several plant and animal viruses.
Kira C.M. Neller +2 more
doaj +1 more source
The future of antiviral immunotoxins [PDF]
, 2016 There is a constant need for new therapeutic interventions in a wide range of infectious diseases. Over the past few years, the immunotoxins have entered the stage as promising antiviral treatments.
Høy Jakobsen, Mette +3 more
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The cytolytic T lymphocyte response to the murine cytomegalovirus [PDF]
, 1984 During the acute cytolytic T lymphocyte (CTL) response of mice to infection with the murine cytomegalovirus two independent populations of activated interleukin-receptive CTL precursors can be demonstrated.
Ada +25 more
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Inhibition of herpes simplex virus DNA synthesis by pokeweed antiviral protein [PDF]
Antimicrobial Agents and Chemotherapy, 1983 Pokeweed antiviral protein at a concentration of 3 microM inhibited both the synthesis and release of infectious herpes simplex virus type 1 in cell culture by 90 and 99%, respectively. Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus yields than was the simultaneous ...
G J, Teltow, J D, Irvin, G M, Aron
openaire +2 more sources
Pokeweed Antiviral Protein Inhibits Brome Mosaic Virus Replication in Plant Cells [PDF]
Journal of Biological Chemistry, 2005 Pokeweed antiviral protein (PAP) is a ribosome-inactivating protein isolated from the pokeweed plant (Phytolacca americana) that inhibits the proliferation of several plant and animal viruses. We have shown previously that PAP and nontoxic mutants of PAP can directly depurinate brome mosaic virus (BMV) RNA in vitro, resulting in reduced viral protein ...
Daniel, Picard +2 more
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Dianthin and Its Potential in Targeted Tumor Therapies [PDF]
, 2019 Dianthin enzymes belong to ribosome-inactivating proteins (RIPs) of type 1, i.e., they only consist of a catalytic domain and do not have a cell binding moiety.
Fuchs, Hendrik
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