Results 91 to 100 of about 1,915,574 (342)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
The uniqueness of the SDPS-set of the symplectic dual polar space $DW(4n-1,q)$, $n \geq 2$ [PDF]
, 2009 SDPS-sets are very nice sets of points in dual polar spaces which themselves carry the structure of dual polar spaces. They were introduced in \cite{DB-V:2} because they gave rise to new valuations and hyperplanes of dual polar spaces.
De Bruyn, Bart
core
Seeded Growth of AlN Layers on Al‐ and N‐Polar AlN Seeds by the Cu–Al–Ca Solution Growth Method [PDF]
, 2023 Jiafu Han +7 more
openalex +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Apuntes sobre mestizaje e hibridez: los riesgos de la metáfora
Kipus: Revista Andina de Letras y Estudios CulturalesArchivo histórico de Kipus: Revista Andina de Letras y Estudios Culturales, 1997. Esta información es parte del repositorio institucional UASB-Digital, de la Universidad Andina Simón Bolívar, Sede Ecuador.
Antonio Cornejo Polar
doaj
MathematicsThe influence of polar ice-covered environments on the corrosion-related static electric field (CRSE) of underwater vehicles is critical for understanding and applying the characteristics of underwater electric fields in polar regions.
Mingjie Qiu +4 more
doaj +1 more source
Ultra-stable oscillator with complementary transistors [PDF]
, 1974 A high frequency oscillator, having both good short and long term stability, is formed by including a piezoelectric crystal in the base circuit of a first bi-polar transistor circuit, the bi-polar transistor itself operated below its transitional ...
Kleinberg, L. L.
core +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source