Results 101 to 110 of about 859,907 (314)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Foreword: Oslo Science Conference, 8-12 June 2010: selected IPY papers [PDF]
, 2011 Billed as ‘‘the largest polar gathering ever’’, the Oslo Science Conference, held in June 2010, marked the conclusion of the fourth International Polar Year (IPY).As a country with management responsibilities for areas in both the Antarctic and the ...
Goldman, Helle
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CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
White-beaked dolphins trapped in the ice and eaten by polar bears [PDF]
, 2015 Polar bears (Ursus maritimus) depend on sea ice, where they hunt ice-associated seals. However, they are opportunistic predators and scavengers with a long list of known prey species.
Agnès Brenière +7 more
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Polar bears (Ursus maritimus) mating during late June on the pack ice of northern Svalbard, Norway [PDF]
, 2015 Polar bears are seasonal breeders and typically mate from late March to early May. Implantation is, however, delayed until autumn, which can allow plasticity in the date of mating.
Aars, Jon +3 more
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
, 2011 These two edited volumes, which cover much of the same ground, both begin from a common premise: polar tourism, as its been experienced by wealthy travellers for over a century, has a very definite shelf life.
P.J. Capelotti, Capelotti, P. J.
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Low protein variability and genetic similarity between populations of the polar bear (Ursus maritimus) [PDF]
, 2010 Blood samples from a total of 460 polar bears (Ursus maritimus) from various Arctic regions, but excluding the USSR, were collected during the period 1967-1981 to study electrophoretic variation in different proteins.
Larsen, Thor +3 more
core +1 more source