Results 121 to 130 of about 859,907 (314)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

open access: yesMolecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler   +3 more
wiley   +1 more source

The polar bear Ursus maritimus feeding in a seabird colony in Frans Josef Land [PDF]

open access: yes, 1993
During the second half of August 1992 polar bears were observed feeding intensively in the little auk Alle alle colony on Rubini Rock, Hooker Island, Frans Josef Land. They dug out nests eating eggs, chicks and adult birds. Their activity results in both
Lech Stempniewicz, Stempniewicz, Lech
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Polar Research evolves, and Norway and the IPY

open access: yes, 2007
March marks the start of the International Polar Year (IPY) and I am very pleased to announce on this occasion that we’ve joined hands with Blackwell Publishing, which will henceforth publish the journal while editorial control remains with the editorial
Goldman, Helle V.
core   +1 more source

Corrigendum [PDF]

open access: yes, 2016
No abstract available.(Published: 9 May 2016)Citation: Polar Research 2016, 35, 31998,http://dx.doi.org/10.3402/polar.v35 ...
Goldman, Helle
core   +1 more source

Le Paris des Aventures extraordinaires d’Adèle Blanc-Sec de Jacques Tardi

open access: yesGéographie et Cultures, 2007
Piece of art, space and society are here approached in a relational perspective which focuses on the links they entertain. More precisely, the question of the city representation in the comic-book concerns geography insomuch as this artistic genre ...
Géraldine Molina
doaj   +1 more source

Polarizing Persuasion

open access: yesGames and Economic Behavior
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Axel Anderson, Nikoloz Pkhakadze
openaire   +3 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Revisiting perceptions and evolving culture: a community dialogue on women in polar research [PDF]

open access: yes, 2018
Women have made outstanding contributions to polar research in recent decades, though full engagement may be hindered by persistent inequities, including notably the prevalence of workplace harassment.
Seag, M.   +7 more
core   +1 more source

Home - About - Disclaimer - Privacy