Results 11 to 20 of about 6,425 (167)

Analysis of codon usage and nucleotide composition bias in polioviruses [PDF]

Virology Journal, 2011
Background Poliovirus, the causative agent of poliomyelitis, is a human enterovirus and a member of the family of Picornaviridae and among the most rapidly evolving viruses known.
Gu Yuan-xing, Ding Yao-zhong, Ma Li-na, Chen Hao-tai, Zhou Jian-hua, Liu Wen-qian, Wang Meng, Zhang Jie, Liu Yong-sheng   +8 more
doaj   +2 more sources

Emergence of Vaccine-derived Polioviruses, Democratic Republic of Congo, 2004–2011 [PDF]

Emerging Infectious Diseases, 2013
Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004–2011 were characterized and found to be vaccine-derived type 2 polioviruses (VDPV2s).
Nicksy Gumede, Olivia Lentsoane, Cara C. Burns, Mark Pallansch, Esther de Gourville, Riziki Yogolelo, Jean Jacques Muyembe-Tamfum, Adrian Puren, Barry D. Schoub, Marietjie Venter   +9 more
doaj   +2 more sources

Epidemiology and genetic characterization of orphan polioviruses in Africa, 2022–2024: Unmasking silent transmission and implications for eradication

Vaccine: X
Background: The continued detection of orphan polioviruses, defined by ≥ 1.5 % nucleotide divergence in the VP1-coding region of the virus compared with the VP1 of previous circulating isolates, presents a significant challenge to polio eradication ...
Brook Tesfaye, Julius E. Chia, Terna Nomhwange, D. Collins Owuor, Ticha Johnson Muluh, Safdar Nosheen, Arthur Yannick Doungmo Wakem, Abdullateef Jimoh, Akif Saatcioglu, Kebba Touray, Abdulahi Walla Hamisu, Modjirom Ndoutabe, Jamal A. Ahmed, Anfumbom Kfutwah   +13 more
doaj   +2 more sources

Intratypic differentiation of polioviruses isolated from suspected cases of poliomyelitis in Brazil during the period of 1990 to 1993

Memorias do Instituto Oswaldo Cruz, 1994
This study analyzed 3129 fecal samples derived from 1626 patients with sudden onset acute flaccid paralysis clinically compatible with poliomyelitis. The samples were collected in the period ranging from January 1990 to September 1993 in all regions of ...
A. M. B. de Filippis, H. G. Schatzmayr, F. C. Ferreira, S. A. R. Chagas, M. C. Costa, A. P. Santos, E. E. da Silva   +6 more
doaj   +2 more sources

The detection of 3 ambiguous type 2 vaccine-derived polioviruses (VDPV2s) in Uganda

Virology Journal, 2018
Background The Oral Polio Vaccine (OPV or Sabin) is genetically unstable and may mutate to form vaccine-derived polioviruses (VDPVs). Methods In 2014, two VDPVs type 2 were identified during routine surveillance of acute flaccid paralysis (AFP) cases ...
Mary Bridget Nanteza, Barnabas Bakamutumaho, Annet Kisakye, Prossy Namuwulya, Henry Bukenya, Edson Katushabe, Josephine Bwogi, Charles Rutebarika Byabamazima, Raffaella Williams, Nicksy Gumede   +9 more
doaj   +2 more sources

Frequency of isolation of polioviruses and non polio enteroviruses from patients with acute flaccid paralysis, enterovirus infection and children from groups at risk [PDF]

Журнал инфектологии, 2014
The article describes the frequency of isolation of polioviruses and non polio enteroviruses from different categories of the investigated children. The percentage of detection of polioviruses from the patients with acute flaccid paralysis was lower than
N. I. Romanenkova, M. A. Bichurina, N. R. Rozaeva   +2 more
doaj   +2 more sources

Vaccine-Derived Polioviruses, Central African Republic, 2019

Emerging Infectious Diseases, 2021
Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from
Marie-Line Joffret, Joël Wilfried Doté, Nicksy Gumede, Marco Vignuzzi, Maël Bessaud, Ionela Gouandjika-Vasilache   +5 more
doaj   +2 more sources

In-Vitro Inactivation of Sabin-Polioviruses for Development of Safe and Effective Polio Vaccine

Vaccines, 2020
After years of global collaboration; we are steps away from a polio-free world. However, the currently conventional inactivated polio vaccine (cIPV) is suboptimal for the post eradication era.
Asmaa A. Abd-Elghaffar, Mohamed E. Rashed, Amal E. Ali, Magdy A. Amin   +3 more
doaj   +2 more sources

Evolution and circulation of type-2 vaccine-derived polioviruses in Nad Ali district of Southern Afghanistan during June 2009-February 2011.

PLoS ONE, 2014
Oral polio vaccine has been used successfully as a powerful tool to control the spread of wild polioviruses throughout the world; however, during replication in under immunized children, some vaccine viruses revert and acquire the neurovirulent ...
Salmaan Sharif, Bilal Haider Abbasi, Adnan Khurshid, Muhammad Masroor Alam, Shahzad Shaukat, Mehar Angez, Muhammad Suleman Rana, Syed Sohail Zahoor Zaidi   +7 more
doaj   +2 more sources

Vaccine-Derived Polioviruses and Children with Primary Immunodeficiency, Iran, 1995–2014

Emerging Infectious Diseases, 2016
Widespread use of oral poliovirus vaccine has led to an ≈99.9% decrease in global incidence of poliomyelitis (from ≈350,000 cases in 1988 to 74 cases in 2015) and eradication of wild-type poliovirus serotypes 2 and 3.
Mohammadreza Shaghaghi, Shohreh Shahmahmoodi, Hassan Abolhassani, Saeed Soleyman-jahi, Leila Parvaneh, Sussan Mahmoudi, Zahra Chavoshzadeh, Reza Yazdani, Seyed Mohsen Zahraei, Mohsen Ebrahimi, Mohammad H. Eslamian, Hamideh Tabatabaie, Maryam Yousefi, Yaghoob M. Kandelousi, Aliasghar Oujaghlou, Nima Rezaei, Asghar Aghamohammadi   +16 more
doaj   +2 more sources