Results 51 to 60 of about 11,399 (257)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Rationale, objectives and design of the HEart failuRe ObsErvational Study of the Polish Cardiac Society (HEROES) [PDF]

Heart failure (HF) has become one of the most important contemporary medical challenges. A report from the Polish Cardiac Society states that 1.2 million people in Poland have HF, characterized by a 40% 5-year mortality rate, annual treatment costs of ...
Morawiec, R, Niewada, M, Janion, M, Zdrojewski, T, Poloński, L, Straburzyńska-Migaj, E, Mitkowski, P, Ponikowski, P, Gąsior, M, Nessler, J, Coats, A, Gierlotka, M, Kaźmierczak, J, Hryniewiecki, T, Grabowski, M, Drożdż, J, Krzesiński, P, Wożakowska-Kapłon, B, Rosano, G, Witkowski, A, Drozd, M, McMurray, J, Kasprzak, JD, Maggioni, A, Opolski, G, Pawlak, A, Jankowska, EA, Leszek, P, Pruszczyk, P, Kuch, M, Gruchała, M, Seferovic, P, Metra, M   +32 more
core   +1 more source

Unraveling the impact of human cerebrospinal fluid on human neural stem cell fate

Frontiers in Cell and Developmental Biology
Human neural stem/progenitor cells (hNSCs) can potentially treat neurological diseases, but their low survival and proliferation rates after transplantation remain challenging.
Klaudia Radoszkiewicz, Aleksandra Bzinkowska, Monika Sypecka, Dorota Sulejczak, Daniela Ferrari, Maurizio Gelati, Angelo Luigi Vescovi, Angelo Luigi Vescovi, Anna Sarnowska   +8 more
doaj   +1 more source

Clinical cell therapy guidelines for neurorestoration (IANR/CANR 2022)☆

Journal of Neurorestoratology, 2022
Cell therapy has been shown to be a crucial clinical therapeutic option for central nervous system diseases or damage. Promoting standardization of clinical cell therapy procedures is essential for professional associations devoted to cell therapy.
Hongyun Huang, Ziad M. Al Zoubi, Gustavo Moviglia, Hari Shanker Sharma, Anna Sarnowska, Paul R. Sanberg, Lin Chen, Qun Xue, Dario Siniscalco, Shiqing Feng, Hooshang Saberi, Xiaoling Guo, Mengzhou Xue, Milan R. Dimitrijevic, Russell J. Andrews, Gengsheng Mao, Robert Chunhua Zhao, Fabin Han   +17 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Machine learning sparse tight-binding parameters for defects

, 2022
Funding Information: We acknowledge support from the FWF DACH project I3827-N36, COST action CA18234, the Academy of Finland through projects 316601 and 334532 and the doctoral colleges Solids4Fun W1243-N16 funded by the FWF and TU-D funded by TU Wien ...
Todorović, Milica, Schattauer, Christoph, Ghosh, Kunal, Libisch, Florian, Rinke, Patrick   +4 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Will ChatGPT pass the Polish specialty exam in radiology and diagnostic imaging? Insights into strengths and limitations

, 2023
Purpose: Rapid development of artificial intelligence has aroused curiosity regarding its potential applications in medical field. The purpose of this article was to present the performance of ChatGPT, a state-of-the-art language model in relation to ...
Sylwia Mielcarska, Paszkiewicz, Iga, Magdalena Stencel, Kufel, Jakub, Bartnikowska, Wiktoria, Wiktoria Bartnikowska, Janik, Michał, Jakub Kufel, Michał Janik, Łukasz Czogalik, Katarzyna Gruszczyńska, Stencel, Łukasz, Mielcarska, Sylwia, Iga Paszkiewicz, Bielówka, Michał, Stencel, Katarzyna, Michał Bielówka, Stencel, Magdalena   +17 more
core   +1 more source

A comprehensive approach to transdermal drug delivery through the skin: Ibuprofen derivatives in semi-solid formulations [PDF]

, 2023
. This article presents a comprehensive study on the formulation and evaluation of pharmaceutical emulsions for topical drug delivery. The research focused on emulsions containing ibuprofen and its derivatives (sodium and L-lysine propyl ester salts ...
Łukasz Kucharski, Grzegorz Story, Anna Nowak, Karolina Bilska, Wiktoria Duchnik, Anna Story, Paula Elżbieta Ossowicz-Rupniewska   +6 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source