Results 111 to 120 of about 5,163,498 (211)

Polo-like kinases, an introduction [PDF]

Oncogene, 2005
openaire   +2 more sources

Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition

, 2014
The deregulation of Polo-like kinase 1 is inversely linked to the prognosis of patients with diverse human tumors. Targeting Polo-like kinase 1 has been widely considered as one of the most promising strategies for molecular anticancer therapy. While the
Yuan, Juping, Zimmer, Brigitte, Louwen, Frank, Kreis, Nina-Naomi   +3 more
core   +1 more source

Polo-like kinase 3 is associated with poor prognosis and regulates proliferation and metastasis in prostate cancer

, 2019
Chunhao Lin,1,2,* Shoumin Bai,1,3,* Tao Du,4 Yiming Lai,2 Xianju Chen,5 Shengmeng Peng,2 Xiaoming Ma,2 Wanhua Wu,2 Zhenghui Guo,1,2 Hai Huang1,2 1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial
Lai Y, Bai S, Lin C, Guo Z, Du T, Peng S, Huang H, Ma X, Chen X, Wu W   +9 more
core  

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio
Glioblastoma (GBM) is a highly malignant brain tumor with limited treatment options. Polo‐like kinase 2 (PLK2), a member of the polo‐like kinase family, has been variably implicated in cancer, but its role in GBM has not been fully elucidated.
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
doaj   +1 more source

The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase

, 2002
The separation of sister chromatids in anaphase depends on the dissociation of cohesin from chromosomes. In vertebrates, some cohesin is removed from chromosomes at the onset of anaphase by proteolytic cleavage.
Kelm, O., Sumara, Izabela, Stukenberg, P. Todd, Peters, Jan-Michael, Nigg, E. A., Vorlaufer, E., Nigg, Erich, Vorlaufer, Elisabeth, Kelm, Olaf, Nigg, Erich A., Sumara, I., Redemann, N., Peters, J. M., Stukenberg, P.Todd, Redemann, Norbert, Stukenberg, P. T.   +15 more
core   +1 more source

Crystal structure of the polo-box domain of polo-like kinase 2

, 2015
Polo-like kinase 2 (PLK2) is a crucial regulator in cell cycle progression. DNA damage response, and neuronal activity. PLK2 is characterized by the conserved N-terminal kinase domain and the unique C-terminal polo-box domain (PBD).
Shan, Hong-Mei, Wang, Tao, Quan, Jun-Min
core   +1 more source

Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4. [PDF]

RSC Chem Biol
Kovacevic A, Salim A, Borges C, Meraldi P, Hoogendoorn S.   +4 more
europepmc   +2 more sources

Anthropometric and physiological changes in elite female water polo players during a training year [PDF]

, 2008
The aim of the current study was to monitor physiological and anthropometric characteristics of elite female water polo players within the periodized training year. Fourteen subjects participated in the current study.
Marrin, K., Marrin, Kelly, Bampouras, Theodoros, Bampouras, T.   +3 more
core   +1 more source

Polo-like kinase 4 phosphorylates Chk2 [PDF]

Cell Cycle, 2009
Steve, Petrinac, Melissa L, Ganuelas, Sepal, Bonni, Jordan, Nantais, John W, Hudson   +4 more
openaire   +2 more sources

Structure-Guided Discovery of Selective Polo-Like Kinase 3 Inhibitors. [PDF]

ACS Med Chem Lett
Yap JL, Lovett G, Mason JW, Tucker J, Boe D, Chen A, Coffman KJ, DaSilva J, Dickinson T, Frattini V, Guan Y, Guiraldelli MF, Hou XJ, Jasti J, Kenton NT, Machin-Rivera R, Marroquin L, McClendon CL, McLaughlin M, Pecora A, Robinson MC, Stock IA, Tria GS, Tuttle J, Young JA, Zhang L, Lee AA.   +26 more
europepmc   +1 more source