Results 101 to 110 of about 5,163,498 (211)

Polo-like kinase 4: the odd one out of the family

Cell Division, 2010
Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
doaj   +1 more source

Targeting the centrosome and polo-like kinase 4 in osteosarcoma

Carcinogenesis, 2018
It has been historically uncertain if extra centrosomes are a cause or consequence of tumorigenesis. Experiments have recently established that overexpression of polo-like kinase 4 (PLK4) promotes centrosome amplification with consequential promotion of cellular aneuploidy. Furthermore, centrosome amplification drives spontaneous tumorigenesis in mice.
Fergal C, Kelleher, Jeska, Kroes, Jeremy, Lewin   +2 more
openaire   +2 more sources

On the regulation of chromosome segregation in human cells : implications of Bub1 Kinase inhibition during cell division [PDF]

, 2015
The maintenance of correct chromosome number (euploidy) during cell division is essential for health. Loss of euploidy is observed in most cancers and is linked to tumorigenesis.
Baron, Anna
core   +1 more source

Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha

eLife, 2017
Cytoplasmic microtubules (cMT) control mitotic spindle positioning in many organisms, and are therefore pivotal for successful cell division. Despite its importance, the temporal control of cMT formation remains poorly understood.
Hiromi Maekawa, Annett Neuner, Diana Rüthnick, Elmar Schiebel, Gislene Pereira, Yoshinobu Kaneko   +5 more
doaj   +1 more source

Polo-like kinase-1 in DNA damage response

BMB Reports, 2014
Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1.
Sun-Yi, Hyun, Hyo-In, Hwang, Hyo-In, Hwan, Young-Joo, Jang   +3 more
openaire   +3 more sources

SYNTHETIC DOSAGE LETHAL INTERACTIONS OF POLO-LIKE KINASE 1 AND THEIR APPLICATION IN CANCER THERAPEUTICS [PDF]

, 2020
Targeted therapies are crucial for personalizing cancer treatment, but tumour heterogeneity presents a challenge in the identification of effective targets.
Cunningham, Chelsea E
core  

Polo-like kinases and centrosome regulation [PDF]

Oncogene, 2002
Wei, Dai, Qi, Wang, Frank, Traganos
openaire   +2 more sources

Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cells

This study investigated Polo-like kinase 1, a mitotic regulator often over-expressed in solid tumors and adult hematopoietic malignancies, as a potential new target in the treatment of pediatric acute lymphoblastic leukemia.
Caron HN, Williamson D, Horstmann M, Allen M, Clifford SC, Exalto C, Hartsink-Segers SA, Pieters R, Den Boer ML   +8 more
core   +4 more sources

KLF5 aggravates osteoarthritis progression by inhibiting chondrocyte autophagy via transcriptional activation of PLK2

Scientific Reports
This study aims to investigate the regulatory role of the Krüppel-like factor 5 (KLF5)/Polo-like kinase 2 (PLK2) axis in osteoarthritis (OA) and its effects on chondrocyte function. An OA mouse model was established.
Bin Wang, Hongliang Zhang, Zhiyong Fan, Haoye Shi, Feiyang Huang, Hua Zhang   +5 more
doaj   +1 more source

Purification and Cloning of a Protein Kinase That Phosphorylates and Activates the Polo-Like Kinase Plx1

, 1998
The Xenopus polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation.
Eleanor Erikson, Yue-Wei Qian, James L. Maller   +2 more
core   +1 more source