Results 81 to 90 of about 15,983 (179)

Polo-like kinase-1 in DNA damage response

BMB Reports, 2014
Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1.
Sun-Yi, Hyun, Hyo-In, Hwang, Hyo-In, Hwan, Young-Joo, Jang   +3 more
openaire   +3 more sources

Computational Design of Targeted Inhibitors of Polo-Like Kinase 1 (Plk1)

Bioinformatics and Biology Insights, 2012
Computational design of small molecule putative inhibitors of Polo-like kinase 1 (Plk1) is presented. Plk1, which regulates the cell cycle, is often over expressed in cancers. Down regulation of Plk1 has been shown to inhibit tumor progression.
Krupa S. Jani, D.S. Dalafave
doaj   +2 more sources

CRL4 DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication

Life Science Alliance
This study identifies the E3 ubiquitin ligase, CRL4DCAF1, as a new regulator of polo-like kinase 4, PLK4, protein levels in the G2 phase of the cell cycle to prevent premature duplication of centrioles.
Josina Grossmann, Anne-Sophie Kratz, Alina Kordonsky, Gali Prag, Ingrid Hoffmann   +4 more
doaj   +1 more source

Polo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication

Cell Division, 2012
Regulation of cell cycle progression is important for the maintenance of genome integrity, and Polo-like kinases (Plks) have been identified as key regulators of this process.
Song Bing, Liu X Shawn, Liu Xiaoqi
doaj   +1 more source

WAC Promotes Polo-like Kinase 1 Activation for Timely Mitotic Entry

Cell Reports, 2018
Summary: The key mitotic regulator Polo-like kinase 1 (Plk1) is activated during G2 phase by Aurora A kinase (AurkA)-mediated phosphorylation of its activation loop, which is important for timely mitotic entry.
Feifei Qi, Qinfu Chen, Hongxia Chen, Haiyan Yan, Binbin Chen, Xingfeng Xiang, Cai Liang, Qi Yi, Miao Zhang, Hankun Cheng, Zhenlei Zhang, Jun Huang, Fangwei Wang   +12 more
doaj   +1 more source

Polo-like kinase 4: the odd one out of the family

Cell Division, 2010
Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
doaj   +1 more source

Targeting the centrosome and polo-like kinase 4 in osteosarcoma

Carcinogenesis, 2018
It has been historically uncertain if extra centrosomes are a cause or consequence of tumorigenesis. Experiments have recently established that overexpression of polo-like kinase 4 (PLK4) promotes centrosome amplification with consequential promotion of cellular aneuploidy. Furthermore, centrosome amplification drives spontaneous tumorigenesis in mice.
Fergal C, Kelleher, Jeska, Kroes, Jeremy, Lewin   +2 more
openaire   +2 more sources

Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha

eLife, 2017
Cytoplasmic microtubules (cMT) control mitotic spindle positioning in many organisms, and are therefore pivotal for successful cell division. Despite its importance, the temporal control of cMT formation remains poorly understood.
Hiromi Maekawa, Annett Neuner, Diana Rüthnick, Elmar Schiebel, Gislene Pereira, Yoshinobu Kaneko   +5 more
doaj   +1 more source

Polo-like kinases and centrosome regulation [PDF]

Oncogene, 2002
Wei, Dai, Qi, Wang, Frank, Traganos
openaire   +2 more sources

KLF5 aggravates osteoarthritis progression by inhibiting chondrocyte autophagy via transcriptional activation of PLK2

Scientific Reports
This study aims to investigate the regulatory role of the Krüppel-like factor 5 (KLF5)/Polo-like kinase 2 (PLK2) axis in osteoarthritis (OA) and its effects on chondrocyte function. An OA mouse model was established.
Bin Wang, Hongliang Zhang, Zhiyong Fan, Haoye Shi, Feiyang Huang, Hua Zhang   +5 more
doaj   +1 more source