Results 161 to 170 of about 5,163,498 (211)

Fine-tuning probes for fluorescence polarization binding assays of bivalent ligands against polo-like kinase 1 using full-length protein. [PDF]

Bioorg Med Chem
Tsuji K, Tamamura H, Burke TR.
europepmc   +1 more source

MYC and HSF1 Cooperate to Drive Sensitivity to Polo-like Kinase 1 Inhibitor Volasertib in High-grade Serous Ovarian Cancer. [PDF]

Cancer Res Commun
Williams I, O'Malley M, DeHart H, Walker B, Ulhaskumar V, Jothirajah P, Ray H, Landrum LM, Delaney JR, Nephew KP, Carpenter RL.   +10 more
europepmc   +1 more source

Testis- and ovary-expressed polo-like kinase transcripts and gene duplications affect male fertility when expressed in the Drosophila melanogaster germline. [PDF]

G3 (Bethesda)
Najera P, Dratler OA, Mai AB, Elizarraras M, Vanchinathan R, Gonzales CA, Meisel RP.   +6 more
europepmc   +1 more source

A limitation lifted: A conditional knockdown system reveals essential roles for Polo-like kinase and Aurora kinase 1 in <i>Trypanosoma cruzi</i> cell division. [PDF]

Proc Natl Acad Sci U S A
Wiedeman J, Harrison R, Etheridge RD.
europepmc   +1 more source

Polo-like kinase inhibition leads to neuroprotection of neurons bearing alpha-synuclein Lewy body-like inclusions <i>in vivo</i>. [PDF]

MicroPubl Biol
Rose EP, Banga JS, Unni VK.
europepmc   +1 more source

Correction for Park et al., Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

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Polo-Like Kinases Inhibitors

Current Medicinal Chemistry, 2012
Polo-like kinases (PLKs) are a family of serine/threonine kinases that play crucial roles in multiple stages of mitosis. PLK1 is the most studied member of the family. It is overexpressed in a wide spectrum of cancer types and is a promising target in oncology. Most of PLK1 inhibitors are ATP-competitive.
GARUTI, LAURA, ROBERTI, MARINELLA, BOTTEGONI, GIOVANNI   +2 more
openaire   +3 more sources

The family of polo-like kinases

1996
Here we discuss members of a new family of serine/threonine protein kinases with a likely role in cell cycle control. These kinases are referred to as polo-like kinases, after the prototypic founding member of the family, the polo gene product of Drosophila melanogaster. The polo kinase was originally identified in mutants that display abnormal mitotic
Lynne D. Berry, Roy M. Golsteyn, Heidi A. Lane, Kirsten E. Mundt, Lionel Arnaud, Erich A. Nigg   +5 more
openaire   +2 more sources

Polo-like kinases and acute leukemia

Oncogene, 2018
Acute leukemia is a common malignancy among children and adults worldwide and many patients suffer from chronic health issues using current therapeutic approaches. Therefore, there is a great need for the development of novel and more specific therapies with fewer side effects.
Oksana, Goroshchuk, Iryna, Kolosenko, Linda, Vidarsdottir, Alireza, Azimi, Caroline, Palm-Apergi   +4 more
openaire   +2 more sources

Progress in the Discovery of Polo-like Kinase Inhibitors

Current Topics in Medicinal Chemistry, 2005
Polo-like kinases (PLKs) are key enzymes that control mitotic entry of proliferating cells and regulate many aspects of mitosis necessary for successful cytokinesis. Of the four known human PLKs, PLK1 is the best characterized and is overexpressed in many tumour types with aberrant elevation frequently constituting a prognostic indicator of poor ...
Campbell, McInnes, Mokdad, Mezna, Peter M, Fischer   +2 more
openaire   +2 more sources