Results 171 to 180 of about 5,163,498 (211)

Polo-like kinase inhibitor BI2536 induces eryptosis

Wiener Medizinische Wochenschrift, 2022
BI2536 is potent inhibitor of polo-like kinases PLK1, 2, and 3. The inhibition of PLKs in nucleated cells induces apoptosis by perturbing the cell cycle with consequent engagement of mitotic catastrophe. BI2536 is being tested as chemotherapy in various phase I/II/III clinical trials.
Mohamed, Jemaà, Raja, Mokdad Gargouri, Florian, Lang   +2 more
openaire   +2 more sources

Polo-like kinase inhibitors in hematologic malignancies

Critical Reviews in Oncology/Hematology, 2016
Polo-like kinases (Plk) are key regulators of the cell cycle and multiple aspects of mitosis. Two agents that inhibit the Plk signaling pathway have shown promising activity in patients with hematologic malignancies and are currently in phase III trials.
Chetasi Talati, Elizabeth A. Griffiths, Meir Wetzler, Eunice S. Wang   +3 more
openaire   +2 more sources

Discovery of thiophene inhibitors of polo-like kinase

Bioorganic & Medicinal Chemistry Letters, 2009
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
Kyle A, Emmitte, C Webb, Andrews, Jennifer G, Badiang, Ronda G, Davis-Ward, Hamilton D, Dickson, David H, Drewry, Holly K, Emerson, Andrea H, Epperly, Daniel F, Hassler, Victoria B, Knick, Kevin W, Kuntz, Timothy J, Lansing, James A, Linn, Robert A, Mook, Kristen E, Nailor, James M, Salovich, Glenn M, Spehar, Mui, Cheung   +17 more
openaire   +2 more sources

Polo-like kinases and the orchestration of cell division

Nature Reviews Molecular Cell Biology, 2004
Polo-like kinases (Plks) are increasingly recognized as key regulators of mitosis, meiosis and cytokinesis. In agreement with a broad range of proposed functions during cell division, Plks are subject to complex temporal and spatial control. Recent findings are uncovering the mechanisms of Plk regulation, notably their targeting to different cellular ...
Barr, Francis A., Silljé, Herman H. W., Nigg, Erich A.   +2 more
openaire   +3 more sources

Polo-like kinases in cell cycle checkpoint control

Frontiers in Bioscience, 2003
Recent studies from various eukaryotic model systems indicate that polo-like kinases (Plks) play an ever-increasing role in the regulation of cell cycle progression. Early genetic studies have demonstrated that Cdc5, a budding yeast counterpart of vertebrate Plks, is essential for mitosis.
Wei, Dai, Xuan, Huang, Qin, Ruan
openaire   +2 more sources

A destructive role for the Polo-like kinases

Trends in Cell Biology, 1998
Abstract DESCOMBES, P. and NIGG, E. A. (1998) The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts EMBO J . 17, 1328–1335 KOTANI, S. et al . (1998) PKA and MPF-activated Polo-like kinase regulate Anaphase-Promoting Complex activity and mitosis progression Mol.
openaire   +1 more source

Polo-like Kinase 1 as an emerging drug target: structure, function and therapeutic implications

Journal of Drug Targeting, 2021
Mohammad Afzal, Gulam Mustafa Hasan, Md Imtaiyaz Hassan   +2 more
exaly  

Developing Polo-like Kinase 1 Inhibitors

Future Medicinal Chemistry, 2020
Xufeng Huang, Zhouling Xie, Chenzhong Liao   +2 more
openaire   +2 more sources

Polo-Like Kinase (PLK)

2017
Nitin Sharma, Rajni Vaid, Kamal Dev, Anuradha Sourirajan   +3 more
openaire   +1 more source

Virtual screening of natural compounds as selective inhibitors of polo-like kinase-1 at C-terminal polo box and N-terminal catalytic domain

Journal of Biomolecular Structure and Dynamics, 2022
Opeyemi Iwaloye, Olusola Olalekan Elekofehinti, Femi Olawale   +2 more
exaly