The low and variable oral bioavailability of poorly water soluble drugs remains a major concern for the pharmaceutical industry. Spray congealing is an emerging technology for the production of solid dispersion to enhance the bioavailability of poorly ...
Serena Bertoni +2 more
doaj +1 more source
A thermosensitive, mucoadhesive in-situ gel for clonazepam (CLZ) intranasal delivery was developed, which aimed to achieve prolonged in-situ residence and controlled drug release, overcoming problems associated with its oral or parenteral administration.
Marzia Cirri +6 more
doaj +1 more source
Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates. [PDF]
This study aimed to evaluate the anti-cancer effect of a combination therapy of miRNA-29b and genistein loaded in mucin-1 (MUC 1)-aptamer functionalized hybrid nanoparticles in non-small cell lung cancer (NSCLC) A549 cell line. Genistein-miRNA-29b-loaded
Sacko, Koita +2 more
core +1 more source
Pluronic F-127 hydrogel as a promising scaffold for encapsulation of dental-derived mesenchymal stem cells. [PDF]
Dental-derived mesenchymal stem cells (MSCs) provide an advantageous therapeutic option for tissue engineering due to their high accessibility and bioavailability.
Ansari, Sahar +7 more
core +1 more source
Phase Behavior and Structure of Poloxamer Block Copolymers in Protic and Aprotic Ionic Liquids
Ionic liquids are promising media for self-assembling block copolymers in applications such as energy storage. A robust design of block copolymer formulations in ionic liquids requires fundamental knowledge of their self-organization at the nanoscale. To
Aikaterini Tsoutsoura +2 more
doaj +1 more source
Potential Unlocking of Biological Activity of Caffeic Acid by Incorporation into Hydrophilic Gels
Caffeic acid, a phenolic compound with antioxidant and antimicrobial properties, shows promise in the dermatological field. The research aimed to incorporate caffeic acid into hydrophilic gels based on poloxamer 407, carbomer 980, and their mixture in ...
Monika Jokubaite, Kristina Ramanauskiene
doaj +1 more source
Luminescent and absorptive metal-coated emulsions for micro-velocimetry
Fluorescent latex beads have been widely used as tracers in microfluidics over for the last decades. They have the advantages to be density matched with water and to be easily localizable using fluorescence microscopy. We have recently synthesized silver-
Chen, Yong +2 more
core +3 more sources
Comparative Pharmacokinetics, Tissue Distributions, and Effects on Renal Function of Novel Polymeric Formulations of Amphotericin B and Amphotericin B-Deoxycholate in Rats [PDF]
The pharmacokinetic profiles of a traditional formulation of amphotericin B (Fungizone) and novel nanosphere and mixed micelle delivery systems developed for amphotericin B were compared and described.
Echevarria, I. (I.) +4 more
core +1 more source
Abstract BACKGROUND Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as
Kyriaki Safari +5 more
wiley +1 more source
Assessing mucoadhesion in polymer gels : The effect of method type and instrument variables [PDF]
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).The process of mucoadhesion has been widely studied using a wide variety ...
Adriano Reis +10 more
core +3 more sources

