Results 281 to 290 of about 547,441 (316)

Third strand stabilization of poly(U)·poly(A)* poly(U) triplex by the naturally occurring flavone luteolin: A multi-spectroscopic approach

International Journal of Biological Macromolecules, 2017
Naturally occurring flavonoid luteolin (LTN) was found to interact with double stranded poly(A).poly(U) and triple stranded poly(U)·poly(A)*poly(U) with association constants of the order of 104M-1. The association was monitored by various spectroscopic and viscometric techniques. Non-cooperative binding was observed for the association of LTN with two
Richa, Tiwari, Lucy, Haque, Sutanwi, Bhuiya, Suman, Das   +3 more
openaire   +2 more sources

The nature of different influence of Cd2+ ions on the conformational equilibrium of triple-stranded polyribonucleotides poly(U)•poly(A)•poly(U) and poly(I)•poly(A)•poly(I) in aqueous solutions

Biophysics, 2007
The influence of Cd2+ ions on the conformational equilibrium of single-stranded (poly(U), poly(A), poly(I)) and triple-stranded polyribonucleotides (A2I, A2U) in aqueous solutions (0.1 M Na+ pH 7) has been investigated using difference UV spectroscopy and thermal denaturation.
V. A. Sorokin, V. A. Valeev, E. L. Usenko, E. A. Andrus, Yu. P. Blagoi   +4 more
openaire   +1 more source

Observations on the kinetics of action of polyspermine-ribonuclease on poly(A)·Poly(U)

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
Starting from the observation that double-stranded ribonucleic acids are hydrolyzed more rapidly by bovine pancreatic ribonuclease that has been cross-linked to polyspermine, we have made an initial examination of the kinetics of the process. The addition of eight residues of the polyamine serves to strengthen the binding to poly(A).poly(U) 100-fold ...
openaire   +2 more sources

SPECIFIC PHOTOALKYLATION OF POLY U AND OF POLY A WITH 2‐PROPANOL AND THEIR MESSENGER PROPERTIES

Photochemistry and Photobiology, 1980
Abstract—Ultraviolet light induced free radical alkylation of poly U or of poly A with 2‐propanol leads to the specific formation of 6‐(2‐hydroxy 2‐propyl) 5,6‐dihydro‐UMP or 8‐(2‐hydroxy 2‐propyl)‐AMP residues, respectively. The biochemical significance of the alterations in the modified polynucleotides was studied by testing their messenger ...
Z, Livneh, E, Livneh, J, Sperling
openaire   +2 more sources

Effects of deuterium on the thermal stability of the poly A–poly U helix.

Biopolymers, 1972
AbstractThe effect of deuterium on the thermal stability of the polynecleotide double helix formed by the homopolymers polyadenylie acid (poly A)and polyuridylic acid (poly U)has been invertigated by measuring the best capacity as a function of temperature in an automatic scanning adiabatic calorimeter.
openaire   +2 more sources

An adjuvant effect of poly A · poly U on production of antibodies to DNA in rabbits

Journal of Immunological Methods, 1976
The effect of polyadenylate-polyuridylate copolymer (poly A-poly U) on the formation of anti-DNA antibodies in rabbits was investigated. 1) Poly A-poly U proved to be an effective adjuvant for production of antibodies to DNA. These were elicited in rabbits at high titer and were formed at an early stage of immunizations.
E, Okuhara, J, Igarashi, T, Matsumoto
openaire   +2 more sources

Destabilization and stabilization of poly(A) · poly(U) structure by platinum(II) compounds

Biophysics, 2008
On the basis of molecular biophysics, a methodology for the analysis of intramolecular structural order of the polynucleotide duplex poly(A).poly(U) has been developed. It was shown that the combination of circular dichroism spectroscopy with differential scanning calorimetry is an optimal approach, which ensures the screening of a wide set of ...
A A, Bogdanov, Iu V, Ivanov, N A, Kas'ianenko, S A, Potekhin, M A, Surzhik, A L, Timkovskiĭ, S A, Feofanov, R S, Khusainova, K I, Iakovlev   +8 more
openaire   +2 more sources

Surface complex of ZnTMPyP4 metalloporphyrin with double-stranded Poly(A)-Poly(U)

Journal of Inorganic Biochemistry, 2016
This communication presents synthesis and spectral characterization of metalloporphyrin [Zn(X)TMPyP4] (TMPyP4 is 5,10,15,20-tetrakis (N-methylpyridinium-4-yl)porphyrin), and studies its binding onto anionic surface sites of synthetic double stranded polynucleotide Poly(A)-Poly(U).
G. Tolstykh, V. Sizov, A. Kudrev
openaire   +2 more sources

Influence of poly A-poly U on early events in the immune response in vitro

Cellular Immunology, 1972
Abstract Adjuvant action of artificial homopolyribonucleotides and nucleic acid digests was studied in mouse spleen-cell cultures, stimulated with sheep red cells by the technique of Mishell and Dutton. Assays of antibody-forming cells were performed according to the Jerne and Nordin technique.
Jaroslow, B N, Ortiz, ortiz L
openaire   +2 more sources

Efficiency of poly (A).poly(U) as an adjuvant

Immunology Today, 1988
A G, Hovanessian, J, Galabru, Y, Rivière, L, Montagnier   +3 more
openaire   +2 more sources