Results 91 to 100 of about 25,360,752 (379)

RNA polyadenylation sites on the genomes of microorganisms, animals, and plants. [PDF]

open access: yesPLoS ONE, 2013
Pre-messenger RNA (mRNA) 3'-end cleavage and subsequent polyadenylation strongly regulate gene expression. In comparison with the upstream or downstream motifs, relatively little is known about the feature differences of polyadenylation [poly(A)] sites ...
Xiu-Qing Li, Donglei Du
doaj   +1 more source

Modification of Poly(5,6-epoxy-l-norleucine) Gives Functional Polypeptides with Alternative Side-Chain Linkages. [PDF]

open access: yes, 2020
The preparation and characterization of a new epoxide containing polypeptide, poly(5,6-epoxy-l-norleucine), via postpolymerization modification of poly(l-homoallylglycine) is described.
Deming, Timothy J   +2 more
core  

TLR3 engagement induces IRF-3-dependent apoptosis in androgen-sensitive prostate cancer cells and inhibits tumour growth in vivo [PDF]

open access: yes, 2014
Toll-like receptors (TLRs) are a family of highly conserved transmembrane proteins expressed in epithelial and immune cells that recognize pathogen associated molecular patterns.
A. Tubaro   +10 more
core   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

The synthesis and application of nano doxorubicin-indocyanine green matrix metalloproteinase-responsive hydrogel in chemophototherapy for head and neck squamous cell carcinoma [Corrigendum]

open access: yesInternational Journal of Nanomedicine, 2019
Wang H, Fu Z, Li W, et al. Int J Nanomedicine. 019;14:623–638.Errors were found in several images for Figure 5F, 5G, 6A and 6B. The authors have advised that mistakes were made during the process of organizing the images.
Wang H   +7 more
doaj  

Efficient Method for Molecular Characterization of the 5′ and 3′ Ends of the Dengue Virus Genome

open access: yesViruses, 2020
Dengue is a mosquito-borne disease that is of major importance in public health. Although it has been extensively studied at the molecular level, sequencing of the 5′ and 3′ ends of the untranslated regions (UTR) commonly requires specific approaches for
Alicia Rosales-Munar   +4 more
doaj   +1 more source

A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length

open access: yesRNA: A publication of the RNA Society, 2014
This paper examines the function of the mammalian protein ZC3H14, which is a zinc finger polyadenosine binding protein that may be orthologous to the yeast protein Nab2.
Seth M. Kelly   +5 more
semanticscholar   +1 more source

Poly(1-vinyl-1,2,4-triazolium) poly(ionic liquid)s: synthesis and the unique behavior in loading metal ions

open access: yes, 2016
Herein we report the synthesis of a series of poly(4-alkyl-1-vinyl-1,2,4-triazolium) poly(ionic liquid)s either via straightforward free radical polymerization of their corresponding ionic liquid monomers, or via anion metathesis of the polymer ...
Yuan, Jiayin, Zhang, Weiyi
core   +1 more source

Synthesis and viscosity behavior of poly(γ-p-biphenylmethyl-L-glutamate) in benzene/dichloroacetic acid mixtures, a comparison with poly(γ-benzyl-L-glutamate) [PDF]

open access: yes, 1974
The synthesis of poly(γ-p-biphenylmethyl-L-glutamate), PBPLG, (poly{L-imino-1-[2-(4-biphenylylmethoxycarbonyl)ethyl]-2-oxoethylene}), (1d) is described. The viscosity behavior of this polymer in benzene/dichloroacetic acid mixtures (c=0,2.10 -3 - 1,4.10 -
Bantjes, Adriaan   +4 more
core   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

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