Results 31 to 40 of about 27,595,942 (347)
Birth of a poly(A) tail: mechanisms and control of mRNA polyadenylation
FEBS Open Bio, 2023 During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐end processing reaction in which the pre‐mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail is added to the newly
Juan B. Rodríguez‐Molina +1 more
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Tales of Detailed Poly(A) Tails.
Trends in Cell Biology, 2019 Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm.
Angela L Nicholson, A. Pasquinelli
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eLife, 2019 The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood.
Michael W Webster +2 more
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Poly(A) Tail Shortening by a Mammalian Poly(A)-specific 3′-Exoribonuclease [PDF]
Journal of Biological Chemistry, 1997 3'-Exonucleolytic removal of the poly(A) tail is the first and often rate-limiting step in the decay of many eucaryotic mRNAs. In a cytoplasmic extract from HeLa cells, the poly(A) tail of mRNA was degraded from the 3'-end. In agreement with earlier in vivo observations, prominent decay intermediates differed in length by about 30 nucleotides. The Mg2+-
C G, Körner, E, Wahle
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Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts
bioRxiv, 2019 Inhibitory codon pairs and poly(A) tracts within the translated mRNA cause ribosome stalling and reduce protein output. The molecular mechanisms that drive these stalling events, however, are still unknown.
P. Tesina +9 more
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K-theory of virtually poly-surface groups [PDF]
, 2002 In this paper we generalize the notion of strongly poly-free group to a larger class of groups, we call them strongly poly-surface groups and prove that the Fibered Isomorphism Conjecture of Farrell and Jones corresponding to the stable topological ...
Roushon, S. K.
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Veterinární Medicína, 2019 Critical-sized bone defects are a difficult problem in both human and veterinary medicine. To address this issue, synthetic graft materials have been garnering attention.
Jang Won Yun +3 more
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Mechanism of ribosome stalling during translation of a poly(A) tail
Nature Structural & Molecular Biology, 2019 Faulty or damaged messenger RNAs are detected by the cell when translating ribosomes stall during elongation and trigger pathways of mRNA decay, nascent protein degradation and ribosome recycling.
V. Chandrasekaran +7 more
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Nature Communications, 2019 Message RNA poly(A) tails are vital for their function and regulation. However, the full-length sequence of mRNA isoforms with their poly(A) tails remains undetermined.
Yusheng Liu +3 more
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Evaluation of Stem-Loop Reverse Transcription and Poly-A Tail Extension in MicroRNA Analysis of Body Fluids [PDF]
, 2014 MicroRNA has been demonstrated to be a viable tool for body fluid identification purposes in forensic casework. Stem-loop reverse transcription (slRT) is regularly used for cDNA synthesis from mature miRNA, along with poly-A tail extension.
Dunnett, Hannah +2 more
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