Results 21 to 30 of about 1,999,235 (294)
Poly(A)-Driven and Poly(A)-Assisted Termination: Two Different Modes of Poly(A)-Dependent Transcription Termination [PDF]
Molecular and Cellular Biology, 1998 We mapped the elements that mediate termination of transcription downstream of the chicken betaH- and betaA-globin gene poly(A) sites. We found no unique element and no segment of 3'-flanking DNA to be significantly more effective than any other. When we replaced the native 3'-flanking DNA with bacterial DNA, it too supported transcription termination.
G, Yeung +6 more
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The Dynamic Poly(A) Tail Acts as a Signal Hub in mRNA Metabolism
Cells, 2023 In eukaryotes, mRNA metabolism requires a sophisticated signaling system. Recent studies have suggested that polyadenylate tail may play a vital role in such a system.
Guiying Zhang +4 more
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Exchange reactions of poly(arylene ether ketone) dithioketals with aliphatic diols: formation and deprotection of poly(arylene ether ketal)s [PDF]
, 2017 The dithioketal derivatives of industrially important, semi-crystalline poly(arylene ether ketone)s undergo facile exchange with aliphatic diols in the presence of N-bromo-succinimide to give a range of novel poly(arylene ether ketal)s.
Colquhoun, Howard +2 more
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Poly A- transcripts expressed in HeLa cells. [PDF]
PLoS ONE, 2008 Transcripts expressed in eukaryotes are classified as poly A+ transcripts or poly A- transcripts based on the presence or absence of the 3' poly A tail.
Qingfa Wu +9 more
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Poly(A) Tail Shortening by a Mammalian Poly(A)-specific 3′-Exoribonuclease [PDF]
Journal of Biological Chemistry, 1997 3'-Exonucleolytic removal of the poly(A) tail is the first and often rate-limiting step in the decay of many eucaryotic mRNAs. In a cytoplasmic extract from HeLa cells, the poly(A) tail of mRNA was degraded from the 3'-end. In agreement with earlier in vivo observations, prominent decay intermediates differed in length by about 30 nucleotides. The Mg2+-
C G, Körner, E, Wahle
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iCLIP analysis of RNA substrates of the archaeal exosome
BMC Genomics, 2020 Background The archaeal exosome is an exoribonucleolytic multiprotein complex, which degrades single-stranded RNA in 3′ to 5′ direction phosphorolytically. In a reverse reaction, it can add A-rich tails to the 3′-end of RNA.
Jochen Bathke +9 more
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Birth of a poly(A) tail: mechanisms and control of mRNA polyadenylation
FEBS Open Bio, 2023 During their synthesis in the cell nucleus, most eukaryotic mRNAs undergo a two‐step 3′‐end processing reaction in which the pre‐mRNA is cleaved and released from the transcribing RNA polymerase II and a polyadenosine (poly(A)) tail is added to the newly
Juan B. Rodríguez‐Molina +1 more
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eLife, 2019 The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood.
Michael W Webster +2 more
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Veterinární Medicína, 2019 Critical-sized bone defects are a difficult problem in both human and veterinary medicine. To address this issue, synthetic graft materials have been garnering attention.
Jang Won Yun +3 more
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Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1 [PDF]
, 2002 The toxicity of an abnormally long polyglutamine [poly(Q)] tract within specific proteins is the molecular lesion shared by Huntington's disease (HD) and several other hereditary neurodegenerative disorders.
Benzer, Seymour, Kazemi-Esfarjani, Parsa
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