Results 41 to 50 of about 27,595,942 (347)

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination

Molecules and Cells, 2017
Summary Diverse cellular stressors have been observed to trigger site-specific ubiquitination on several ribosomal proteins. However, the ubiquitin ligases, biochemical consequences, and physiologic pathways linked to these modifications are not known ...
S. Juszkiewicz, R. Hegde
semanticscholar   +1 more source

Segmented poly(A) tails significantly reduce recombination of plasmid DNA without affecting mRNA translation efficiency or half-life

RNA: A publication of the RNA Society, 2019
Extensive research in the past decade has brought mRNA closer to the clinical realization of its therapeutic potential. One common structural feature for all cellular messenger RNAs is a poly(A) tail, which can either be brought in cotranscriptionally ...
Željka Trepotec, J. Geiger, C. Plank, M. Aneja, C. Rudolph   +4 more
semanticscholar   +1 more source

Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase

Cell, 2019
Summary The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail.
Ingmar B. Schäfer, M. Yamashita, J. Schuller, S. Schüssler, Peter Reichelt, M. Strauss, E. Conti   +6 more
semanticscholar   +1 more source

The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes

Genome Biology, 2017
Background All mRNAs are bound in vivo by proteins to form mRNA–protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored. Here, we have analyzed, on a transcriptome-wide scale, how
Olivia S. Rissland, Alexander O. Subtelny, Miranda Wang, Andrew Lugowski, Beth Nicholson, John D. Laver, Sachdev S. Sidhu, Craig A. Smibert, Howard D. Lipshitz, David P. Bartel   +9 more
doaj   +1 more source

Short Poly(A) Tails are a Conserved Feature of Highly Expressed Genes

Nature Structural & Molecular Biology, 2017
Poly(A) tails are important elements in mRNA translation and stability, although recent genome-wide studies have concluded that poly(A) tail length is generally not associated with translational efficiency in nonembryonic cells.
S. Lima, Laura B. Chipman, Angela L Nicholson, Ying-Hsin Chen, Brian A. Yee, Gene W. Yeo, J. Coller, A. Pasquinelli   +7 more
semanticscholar   +1 more source

Sequence specific binding of beta carboline alkaloid harmalol with deoxyribonucleotides: binding heterogeneity, conformational, thermodynamic and cytotoxic aspects. [PDF]

PLoS ONE, 2014
Base dependent binding of the cytotoxic alkaloid harmalol to four synthetic polynucleotides, poly(dA).poly(dT), poly(dA-dT).poly(dA-dT), poly(dG).poly(dC) and poly(dG-dC).poly(dG-dC) was examined by various photophysical and calorimetric studies, and ...
Sarita Sarkar, Prateek Pandya, Kakali Bhadra   +2 more
doaj   +1 more source

Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons

eLife, 2023
A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A hallmark of ALS/FTD pathology is the presence of dipeptide repeat (DPR) proteins, produced from both
Yoshifumi Sonobe, Soojin Lee, Gopinath Krishnan, Yuanzheng Gu, Deborah Y Kwon, Fen-Biao Gao, Raymond P Roos, Paschalis Kratsios   +7 more
doaj   +1 more source

The impact of mRNA poly(A) tail length on eukaryotic translation stages

Nucleic Acids Research
The poly(A) tail plays an important role in maintaining mRNA stability and influences translation efficiency via binding with PABP. However, the impact of poly(A) tail length on mRNA translation remains incompletely understood.
N. Biziaev, A. Shuvalov, Ali Salman, T. Egorova, E. Shuvalova, E. Alkalaeva   +5 more
semanticscholar   +1 more source

Translation of poly(A) tails leads to precise mRNA cleavage

RNA: A publication of the RNA Society, 2017
Translation of poly(A) tails leads to mRNA cleavage but the mechanism and global pervasiveness of this “nonstop/no-go” decay process is not understood.
N. Guydosh, R. Green
semanticscholar   +1 more source

Self-machinery?: steel trusses and the management of ruptures in eighteenth-century Europe [PDF]

, 2013
: Effectiveness Of Rice Husk Ash And Poly Aluminum Chloride In Reducing Exposure Colour Liquid Waste Industry Sasirangan. Sasirangan fabric industry is the textile of industry in Kalimantan Selatan produce wastewater of dyeing cloth sasirangan process ...
A., Syarifudin, Hakim, Luqman Nur, Hamzani, Sulaiman   +2 more
core   +2 more sources