Results 41 to 50 of about 25,360,752 (379)
RNA Turnover: Unexpected Consequences of Being Tailed [PDF]
, 2005 In eukaryotic cells, the 3′ poly(A) tails found on mRNA influence their stability and translation. The discovery of a second nuclear poly(A) polymerase complex has fueled a series of reports defining a new and unexpected role for 3′ end poly(A) tails in ...
Anderson, James T.
core +2 more sources
eLife, 2023 A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A hallmark of ALS/FTD pathology is the presence of dipeptide repeat (DPR) proteins, produced from both
Yoshifumi Sonobe +7 more
doaj +1 more source
Nucleic Acids Research, 2019 Post-transcriptional regulation of gene expression occurs by multiple mechanisms, including subcellular localization of mRNA and alteration of the poly(A) tail length. These mechanisms play crucial roles in the dynamics of cell polarization and embryonic
L. Anhäuser +3 more
semanticscholar +1 more source
Evaluation of Stem-Loop Reverse Transcription and Poly-A Tail Extension in MicroRNA Analysis of Body Fluids [PDF]
, 2014 MicroRNA has been demonstrated to be a viable tool for body fluid identification purposes in forensic casework. Stem-loop reverse transcription (slRT) is regularly used for cDNA synthesis from mature miRNA, along with poly-A tail extension.
Dunnett, Hannah +2 more
core +1 more source
The influence of microRNAs and poly(A) tail length on endogenous mRNA–protein complexes
Genome Biology, 2017 Background All mRNAs are bound in vivo by proteins to form mRNA–protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored. Here, we have analyzed, on a transcriptome-wide scale, how
Olivia S. Rissland +9 more
doaj +1 more source
Poly Vinyl Chloride Additives and Applications - A Review
Journal of Risk Analysis and Crisis Response (JRACR), 2022 A Pure polyvinyl chloride (PVC) is a white, brittle material and it is the third-largest polymers produced after polyethylene and polypropylene as 40 million tons of PVC are produced yearly.
Abdallah S. Elgharbawy
doaj +1 more source
e-Polymers, 2023 Radiation and nuclear technologies have side effects in addition to their important applications, so appropriate shields must be used to protect users and the public from high doses as a result of exposure to this radiation. In this work, the attenuation
Al-Saleh Wafa M. +5 more
doaj +1 more source
Journal of the American Chemical Society, 2014 Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N ...
James, Carrie R. +6 more
openaire +2 more sources
mRNA 3′ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome
Nature, 2017 A fundamental principle in biology is that the program for early development is established during oogenesis in the form of the maternal transcriptome. How the maternal transcriptome acquires the appropriate content and dosage of transcripts is not fully
Marcos Morgan +11 more
semanticscholar +1 more source
Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]
, 2002 Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T. +8 more
core +3 more sources