Results 41 to 50 of about 24,007,230 (395)
eLife, 2019 The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood.
Michael W Webster +2 more
doaj +1 more source
Mechanism of ribosome stalling during translation of a poly(A) tail
Nature Structural & Molecular Biology, 2019 Faulty or damaged messenger RNAs are detected by the cell when translating ribosomes stall during elongation and trigger pathways of mRNA decay, nascent protein degradation and ribosome recycling.
V. Chandrasekaran +7 more
semanticscholar +1 more source
Evaluation of Stem-Loop Reverse Transcription and Poly-A Tail Extension in MicroRNA Analysis of Body Fluids [PDF]
, 2014 MicroRNA has been demonstrated to be a viable tool for body fluid identification purposes in forensic casework. Stem-loop reverse transcription (slRT) is regularly used for cDNA synthesis from mature miRNA, along with poly-A tail extension.
Dunnett, Hannah +2 more
core +1 more source
Veterinární Medicína, 2019 Critical-sized bone defects are a difficult problem in both human and veterinary medicine. To address this issue, synthetic graft materials have been garnering attention.
Jang Won Yun +3 more
doaj +1 more source
Nature Communications, 2019 Message RNA poly(A) tails are vital for their function and regulation. However, the full-length sequence of mRNA isoforms with their poly(A) tails remains undetermined.
Yusheng Liu +3 more
semanticscholar +1 more source
Poly(A) Tail Shortening by a Mammalian Poly(A)-specific 3′-Exoribonuclease [PDF]
Journal of Biological Chemistry, 1997 3'-Exonucleolytic removal of the poly(A) tail is the first and often rate-limiting step in the decay of many eucaryotic mRNAs. In a cytoplasmic extract from HeLa cells, the poly(A) tail of mRNA was degraded from the 3'-end. In agreement with earlier in vivo observations, prominent decay intermediates differed in length by about 30 nucleotides. The Mg2+-
C G, Körner, E, Wahle
openaire +2 more sources
K-theory of virtually poly-surface groups [PDF]
, 2002 In this paper we generalize the notion of strongly poly-free group to a larger class of groups, we call them strongly poly-surface groups and prove that the Fibered Isomorphism Conjecture of Farrell and Jones corresponding to the stable topological ...
Roushon, S. K.
core +5 more sources
RNA: A publication of the RNA Society, 2019 Extensive research in the past decade has brought mRNA closer to the clinical realization of its therapeutic potential. One common structural feature for all cellular messenger RNAs is a poly(A) tail, which can either be brought in cotranscriptionally ...
Željka Trepotec +4 more
semanticscholar +1 more source
Dual Requirement for Yeast hnRNP Nab2p in mRNA poly(A) Tail Length Control and Nuclear Export [PDF]
, 2002 Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control ...
Anderson, James T. +8 more
core +3 more sources
Exchange reactions of poly(arylene ether ketone) dithioketals with aliphatic diols: formation and deprotection of poly(arylene ether ketal)s [PDF]
, 2017 The dithioketal derivatives of industrially important, semi-crystalline poly(arylene ether ketone)s undergo facile exchange with aliphatic diols in the presence of N-bromo-succinimide to give a range of novel poly(arylene ether ketal)s.
Colquhoun, Howard +2 more
core +1 more source