Results 81 to 90 of about 24,007,230 (395)

Genome-wide profiling reveals alternative polyadenylation of mRNA in human non-small cell lung cancer

Journal of Translational Medicine, 2019
Background Lung cancer is the second most common cancer with an extremely poor overall survival rate. Post-transcriptional regulation of gene expression play many important roles in human cancer, and one of the potential mechanisms underlying this is ...
Shirong Zhang, Xiaochen Zhang, Wei Lei, Jiafeng Liang, Yasi Xu, Hailiang Liu, Shenglin Ma   +6 more
doaj   +1 more source

Zika Virus Infection Alters Gene Expression and Poly-Adenylation Patterns in Placental Cells

Pathogens, 2022
Flaviviruses are small RNA viruses that are mainly transmitted via arthropod vectors and are found in tropic and sub-tropical regions. Most infections are asymptomatic (90–95%), but symptoms can be as severe as hemorrhagic fever and encephalitis.
Stephanea L. Sotcheff, John Yun-Chung Chen, Nathan Elrod, Jun Cao, Elizabeth Jaworski, Mugé N. Kuyumcu-Martinez, Pei-Yong Shi, Andrew L. Routh   +7 more
doaj   +1 more source

RNAseq by Total RNA Library Identifies Additional RNAs Compared to Poly(A) RNA Library

BioMed Research International, 2015
The most popular RNA library used for RNA sequencing is the poly(A) captured RNA library. This library captures RNA based on the presence of poly(A) tails at the 3′ end.
Yan Guo, Shilin Zhao, Quanhu Sheng, Ming-Rui Guo, B. Lehmann, J. Pietenpol, D. Samuels, Y. Shyr   +7 more
semanticscholar   +1 more source

Failure to detect "cap" structures in mitochondrial DNA-coded poly(A)-containing RNA from HeLa cells [PDF]

, 1978
The structure of the 5'-termini has been investigated in mitochondrial DNA- coded poly(A)-containing RNA from HeLa cells. For this purpose, mitochondrial RNA isolated from cells labeled for 3 hours with [32P]orthophosphate in the presence of 20 µg/ml ...
Amalric, François, Attardi, Giuseppe, Crews, Stephen, Grohmann, Karel   +3 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Mapping atomistic to coarse-grained polymer models using automatic simplex optimization to fit structural properties

, 2000
We develop coarse-grained force fields for poly (vinyl alcohol) and poly (acrylic acid) oligomers. In both cases, one monomer is mapped onto a coarse-grained bead.
Meyer, Hendrik, Mueller-Plathe, Florian, Reith, Dirk   +2 more
core   +1 more source

Poly(amidoamine)s synthesis, characterisation and interaction with BSA [PDF]

, 2014
Cationic poly(amidoamine)s (PAAs) were synthesised and characterised by NMR and gel permeation chromatography. Their thermal properties were investigated using thermogravimetric analysis and differential scanning calorimetry.
Akinc, Almeida, Anand, Antonov, Boeris, Boeris, Brostow, Bujacz, Coué, Danusso, Deep, Dey, Dhalluin, Ferruti, Ferruti, Ferruti, Funhoff, Giancola, Gill, Gu, Julie L. N. Dubois, Kalogeras, Karayianni, Kishimura, Lakowicz, Lavignac, Lavignac, Lavignac, Leader, Liu, Luo, Nathalie Lavignac, Piest, Plesner, Prevette, Ranucci, Richardson, Richardson, Romanini, Seyrek, Tanzi, Torchilin, van der Aa, Vlasova, von Harpe, Won   +45 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Poly(A): Possible Role in Translation of Poly(A)-Rich RNA

Experimental Biology and Medicine, 1973
A covalently linked region, 100–200 nucleotides long, rich in polyriboadenylic acid [poly(A)], has been identified in rapidly labeled polyribosome-associated RNA and heterogeneous nuclear RNA in a number of eukaryotic cells (1–3), in several specific eukaryotic mRNAs (4–6), and in viral mRNAs (7).
M G, Rosenfeld, I B, Abrass, J, Mendelsohn, H I, Miller, J, Holland   +4 more
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source