Results 81 to 90 of about 27,595,942 (347)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Theory of photoinduced charge transfer in weakly coupled donor-acceptor conjugated polymers: application to an MEH-PPV:CN-PPV pair

, 1997
In a pair of coupled donor-acceptor conjugated polymer chains, it is possible for an exciton photoexcited on either polymer to decay into a hole in the donor polymer's valence band and an electron in the conduction band of the acceptor polymer.
Campbell, Conwell, E.M. Conwell, Fink, Halls, Kepler, Kraabel, Landau, M.W. Wu, Mizes, Morita, Morita, Morita, Rauscher, Rice, Samuel, Sariciftci, Sariciftci, Sariciftci, Wu, Yu, Yu   +21 more
core   +1 more source

A new yeast poly(A) polymerase complex involved in RNA quality control [PDF]

, 2005
Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors.
Štěpánka Vaňáčová, Jeannette Wolf, Georges Martin, Diana Blank, Sabine Dettwiler, Arno Friedlein, Hanno Langen, Gérard Keith, Walter Keller, Phillip Zamore, Wahle, Minvielle-Sebastia, Zhao, Edmonds, Proudfoot, Zorio, Aravind, Holm, Martin, Preker, Martin, Martin, Bard, Read, Saitoh, Wang, Sadoff, Wang, Wang, Crittenden, Kwak, Keller, van Hoof, Kuai, Kadaba, Mitchell, O'Hara, Li, Cheng, Dreyfus, Inoue, Martin, Puig, Lingner, de la Cruz, Wang, Vijayraghavan, Anderson, Gerber, Dirheimer, Mitchell, Walowsky, Dannull, Amarasinghe, Castaño, Basavappa, Kushner, Symmons, Parker, Torchet, Fromont-Racine, Ohnacker, Dichtl, Fountoulakis, Wilm, Dirheimer, Keith, Senger, Dichtl, Christofori, Falquet, Rain   +71 more
core   +4 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Clinical Value of S-poly (T) plus Real-time PCR in Detection of Liver Cancer-related miR-199

Zhongliu Fangzhi Yanjiu, 2020
Objective To explore the advantages and disadvantages of S-poly(T) plus qRT-PCR and Poly (A) qRT-PCR methods in detecting peripheral blood serum miR-199.
WU Juan, ZHANG Yaqin, WU Yunbin, CHEN Min, YU Zhou, CAO Yingping   +5 more
doaj   +1 more source

Poly(2-cyclopropyl-2-oxazoline): from rate acceleration by Cyclopropyl to Thermoresponsive properties [PDF]

, 2011
The synthesis and microwave-assisted living cationic ring-opening polymerization of 2-cyclopropyl-2-oxazoline is reported revealing the fastest polymerization for an aliphatic substituted 2-oxazoline to date, which is ascribed to the electron withdrawing
Baumgartel, Anja, Bloksma, Meta M, Hoogenboom, Richard, Kuse, Anette, Perevyazko, Igor Y, Schubert, Ulrich S, Vollrath, Antje, Weber, Christine   +7 more
core   +2 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Identification of Genes for Improving Cold Sensitivity in Nerve-Damaged Rats Via Lumbar Sympathectomy Using Poly(A)-seq

Journal of Integrative Neuroscience
Background: Lumbar sympathectomy improves blood flow to the lower limbs and is widely used in clinical practice to treat lower limb pain and cold.
Xi Meng, Hanrui Fan, Ping Xu, Lei Yang, Yong Fei, Wenping Zhang   +5 more
doaj   +1 more source

Finding the Minimum-Weight k-Path [PDF]

, 2013
Given a weighted $n$-vertex graph $G$ with integer edge-weights taken from a range $[-M,M]$, we show that the minimum-weight simple path visiting $k$ vertices can be found in time $\tilde{O}(2^k \poly(k) M n^\omega) = O^*(2^k M)$.
B. Monien, F. Ergün, H. Abasi, I. Koutis, I. Koutis, J. Kneis, N. Alon, R. Williams, U. Zwick   +8 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source