Results 1 to 10 of about 203,778 (305)

Textural characteristics and organization of composites with fumed silicas and high-molecular weight compounds

open access: yesХімія, фізика та технологія поверхні, 2022
Various composites with nanosilicas, as well as with other nanooxides, and polymers are of importance from a practical point of view. Detailed textural and morphological characterization, applied here to nanosilicas treated alone and in composites with ...
V. M. Gun'ko
doaj   +1 more source

Conducting Polymer-Infused Electrospun Fibre Mat Modified by POEGMA Brushes as Antifouling Biointerface

open access: yesBiosensors, 2022
Biofouling on surfaces, caused by the assimilation of proteins, peptides, lipids and microorganisms, leads to contamination, deterioration and failure of biomedical devices and causes implants rejection.
Jesna Ashraf   +6 more
doaj   +1 more source

Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis

open access: yesFrontiers in Immunology, 2021
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that mainly damages the hands and feet, which affects 0.5% to 1.0% of the population worldwide.
Jie Huang   +6 more
doaj   +1 more source

Gene dosage effects of poly(A) track-engineered hypomorphs

open access: yesMolecular Therapy: Nucleic Acids, 2021
Manipulation of gene activity through creation of hypomorphic mutants has been a long-standing tool in examining gene function. Our previous studies have indicated that hypomorphic mutants could be created by inserting cis-regulatory sequences composed ...
Geralle Powell   +2 more
doaj   +1 more source

HIV protease cleaves poly(A)-binding protein [PDF]

open access: yesBiochemical Journal, 2006
The PABP [poly(A)-binding protein] is able to interact with the 3′ poly(A) tail of eukaryotic mRNA, promoting its translation. Cleavage of PABP by viral proteases encoded by several picornaviruses and caliciviruses plays a role in the abrogation of cellular protein synthesis.
Álvarez, Enrique   +3 more
openaire   +3 more sources

Evidence that Poly(A) Binding Protein C1 Binds Nuclear Pre-mRNA Poly(A) Tails [PDF]

open access: yesMolecular and Cellular Biology, 2006
In mammalian cells, poly(A) binding protein C1 (PABP C1) has well-known roles in mRNA translation and decay in the cytoplasm. However, PABPC1 also shuttles in and out of the nucleus, and its nuclear function is unknown. Here, we show that PABPC1, like the major nuclear poly(A) binding protein PABPN1, associates with nuclear pre-mRNAs that are ...
Nao, Hosoda   +2 more
openaire   +2 more sources

One‐Step Synthesis of Hydrogen‐Bonded Microcapsules for pH‐Triggered Protein Release

open access: yesSmall Structures, 2023
One‐step microfluidic approach in which interfacial complexation of hydrogen bonding polymers is utilized to prepare pH‐responsive microcapsules is presented.
Leekang Jeon   +4 more
doaj   +1 more source

TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand

open access: yesNature Communications, 2022
TLR3 plays a crucial role in anti-viral immune response by recognizing RNAs produced during virus infection. Here, the authors determine a high resolution structure of the activated cluster of TLR3.
Chan Seok Lim   +6 more
doaj   +1 more source

Measurement of Secondary Structure Changes in Poly-L-lysine and Lysozyme during Acoustically Levitated Single Droplet Drying Experiments by In Situ Raman Spectroscopy

open access: yesSensors, 2022
Drying processes such as spray drying, as commonly used in the pharmaceutical industry to convert protein-based drugs into their particulate form, can lead to an irreversible loss of protein activity caused by protein secondary structure changes.
Julian F. A. Perlitz   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy