Results 1 to 10 of about 122,513 (306)
Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis [PDF]
, 2017 There is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating motor neuron disease. However, discovery of a G4C2 repeat expansion in the C9ORF72 gene as the most common genetic cause of ALS has opened up new avenues for ...
E. A. Perkerson +78 more
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Хімія, фізика та технологія поверхні, 2022 Various composites with nanosilicas, as well as with other nanooxides, and polymers are of importance from a practical point of view. Detailed textural and morphological characterization, applied here to nanosilicas treated alone and in composites with ...
V. M. Gun'ko
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Biosensors, 2022 Biofouling on surfaces, caused by the assimilation of proteins, peptides, lipids and microorganisms, leads to contamination, deterioration and failure of biomedical devices and causes implants rejection.
Jesna Ashraf +6 more
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Promising Therapeutic Targets for Treatment of Rheumatoid Arthritis
Frontiers in Immunology, 2021 Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that mainly damages the hands and feet, which affects 0.5% to 1.0% of the population worldwide.
Jie Huang +6 more
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Gene dosage effects of poly(A) track-engineered hypomorphs
Molecular Therapy: Nucleic Acids, 2021 Manipulation of gene activity through creation of hypomorphic mutants has been a long-standing tool in examining gene function. Our previous studies have indicated that hypomorphic mutants could be created by inserting cis-regulatory sequences composed ...
Geralle Powell +2 more
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One‐Step Synthesis of Hydrogen‐Bonded Microcapsules for pH‐Triggered Protein Release
Small Structures, 2023 One‐step microfluidic approach in which interfacial complexation of hydrogen bonding polymers is utilized to prepare pH‐responsive microcapsules is presented.
Leekang Jeon +4 more
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The RNA Binding Domains of the Nuclear poly(A)-binding Protein [PDF]
Journal of Biological Chemistry, 2003 The nuclear poly(A)-binding protein (PABPN1) is involved in the synthesis of the mRNA poly(A) tails in most eukaryotes. We report that the protein contains two RNA binding domains, a ribonucleoprotein-type RNA binding domain (RNP domain) located approximately in the middle of the protein sequence and an arginine-rich C-terminal domain.
Uwe, Kühn +3 more
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TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand
Nature Communications, 2022 TLR3 plays a crucial role in anti-viral immune response by recognizing RNAs produced during virus infection. Here, the authors determine a high resolution structure of the activated cluster of TLR3.
Chan Seok Lim +6 more
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Sensors, 2022 Drying processes such as spray drying, as commonly used in the pharmaceutical industry to convert protein-based drugs into their particulate form, can lead to an irreversible loss of protein activity caused by protein secondary structure changes.
Julian F. A. Perlitz +3 more
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Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail [PDF]
Scientific Reports, 2018 AbstractEukaryotic mature mRNAs possess a poly adenylate tail (poly(A)), to which multiple molecules of poly(A)-binding protein C1 (PABPC1) bind. PABPC1 regulates translation and mRNA metabolism by binding to regulatory proteins. To understand functional mechanism of the regulatory proteins, it is necessary to reveal how multiple molecules of PABPC1 ...
Ryoichi Sawazaki +8 more
openaire +3 more sources