Results 31 to 40 of about 122,513 (306)

HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS

Frontiers in Cell and Developmental Biology, 2022
The aberrant translation of a repeat expansion in chromosome 9 open reading frame 72 (C9orf72), the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), results in the accumulation of toxic dipeptide repeat (DPR ...
Giulia del Rosso, Giulia del Rosso, Yari Carlomagno, Tiffany W. Todd, Caroline Y. Jones, Mercedes Prudencio, Mercedes Prudencio, Lillian M. Daughrity, Mei Yue, Karen Jansen-West, Jimei Tong, Wei Shao, Yanwei Wu, Monica Castanedes-Casey, Lilia Tabassian, Björn Oskarsson, Karen Ling, Frank Rigo, Dennis W. Dickson, Dennis W. Dickson, Tso-Pang Yao, Leonard Petrucelli, Leonard Petrucelli, Casey N. Cook, Casey N. Cook, Yong Jie Zhang, Yong Jie Zhang   +26 more
doaj   +1 more source

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins [PDF]

, 2016
Neuronal inclusions of poly(GA), a protein unconventionally translated from G 4 C 2 repeat expansions in C9ORF72, are abundant in patients with frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) caused by this mutation.
Tong, J., Boylan, K.B., Cleveland, D.W., Fryer, J.D., Bu, G., Daughrity, L., Yue, M., Castanedes-Casey, M., Xu, Y.-F., Edbauer, D., Kurti, A., Rothstein, J.D., Katzman, R.B., Baker, J.D., Link, C.D., Sasaguri, H., Lagier-Tourenne, C., Grima, J.C., Petrucelli, L., Gendron, T.F., Jiang, J., Dickson, D.W., Rademakers, R., Dickey, C.A., Shinohara, M., Gass, J., Lin, W.-L., Perkerson, E.A., Garrett, A., Stankowski, J.N., Wang, Z.S., Murray, M.E., Zhang, Y.-J., Liesinger, A.M., Jansen-West, K., Chew, J.   +35 more
core   +3 more sources

Structural and Functional Dynamics of Staphylococcus aureus Biofilms and Biofilm Matrix Proteins on Different Clinical Materials

Microorganisms, 2019
Medical device-associated staphylococcal infections are a common and challenging problem. However, detailed knowledge of staphylococcal biofilm dynamics on clinically relevant surfaces is still limited.
Anna K. Hiltunen, Kirsi Savijoki, Tuula A. Nyman, Ilkka Miettinen, Petri Ihalainen, Jouko Peltonen, Adyary Fallarero   +6 more
doaj   +1 more source

Folding of poly-amino acids and intrinsically disordered proteins in overcrowded milieu induced by pH change [PDF]

, 2019
pH-induced structural changes of the synthetic homopolypeptides poly-E, poly-K, poly-R, and intrinsically disordered proteins (IDPs) prothymosin alpha (ProT alpha) and linker histone H1, in concentrated PEG solutions simulating macromolecular crowding ...
Turoverov, Konstantin K., Sitdikova, Asiia K., Kuznetsova, Irina M., Kostyleva, Elena I., Fonin, Alexander V., Stepanenko, Olga V., Antifeeva, Iuliia A., Turoverov, Konstantin К., Polyanichko, Alexander M., Karasev, Maksim M., Uversky, Vladimir N., Silonov, Sergey A., Povarova, Olga I.   +12 more
core   +1 more source

The Yeast Pan2 Protein Is Required for Poly(A)-binding Protein-stimulated Poly(A)-nuclease Activity [PDF]

Journal of Biological Chemistry, 1996
The removal of the mRNA poly(A) tail in the yeast Saccharomyces cerevisiae is stimulated by the poly(A)-binding protein (Pab1p). A large scale purification of the Pab1p-stimulated poly(A) ribonuclease (PAN) identifies a 76-kDa and two 135-Da polypeptides as candidate enzyme subunits.
R, Boeck, S, Tarun, M, Rieger, J A, Deardorff, S, Müller-Auer, A B, Sachs   +5 more
openaire   +2 more sources

Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

Acta Neuropathologica Communications, 2020
A C9orf72 repeat expansion is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis. One of the suggested pathomechanisms is toxicity from dipeptide repeat proteins (DPRs), which are generated via unconventional
Annelies Quaegebeur, Idoia Glaria, Tammaryn Lashley, Adrian M. Isaacs   +3 more
doaj   +1 more source

Synthesis and characterization of size-selective nanoporous polymeric adsorbents for blood purification. [PDF]

, 2009
Crosslinked polystyrene co-divinylbenzene adsorbent microspheres with median diameters between 40 and 300 μm, with an enhanced proportion of mesopores in the range 4–10 nm, have been synthesized using a membrane emulsification technique.
Trochimczuk, Andrzej W., D.J. Malik, Malik, Danish Javed, Chris Webb (7127804), R.G. Holdich, C. Webb, Dale, James A., Iain Roche (7127942), G.L. Warwick, N.A. Hoenich (7128515), G.L. Warwick (7128506), Danish Malik (1254321), Richard Holdich (1253271), J.J. Ramsden (7128503), J.A. Dale (7128512), David Williams (1248024), Warwick, Graham L., Roche, I., Holdich, Richard G., I. Roche, Williams, David John, J.A. Dale, A.W. Trochimczuk, N.A. Hoenich, J.J. Ramsden, D.J. Williams, Hoenich, Nicholas Andrew, Webb, C., Ramsden, Jeremy J., Andrzej W. Trochimczuk (7128509)   +29 more
core   +1 more source

Synthesis of poly-α/β-peptides with tunable sequence via the copolymerization on N-carboxyanhydride and N-thiocarboxyanhydride

iScience, 2021
Summary: The fascinating functions of proteins and peptides in biological systems have attracted intense interest to explore their mimics using polymers, including polypeptides synthesized from polymerization.
Min Zhou, Jingcheng Zou, Longqiang Liu, Ximian Xiao, Shuai Deng, Yueming Wu, Jiayang Xie, Zihao Cong, Zhemin Ji, Runhui Liu   +9 more
doaj   +1 more source

Characterization of Inner and Outer Membrane Proteins from Francisella tularensis Strains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates

mBio, 2017
Francisella tularensis is the causative agent of tularemia and a potential bioterrorism agent. In the present study, we isolated, identified, and quantified the proteins present in the membranes of the virulent type A strain, Schu S4, and the attenuated ...
Deborah M. B. Post, Bram Slütter, Birgit Schilling, Aroon T. Chande, Jed A. Rasmussen, Bradley D. Jones, Alexandria K. D’Souza, Lorri M. Reinders, John T. Harty, Bradford W. Gibson, Michael A. Apicella   +10 more
doaj   +1 more source

Controlling microencapsulation and release of micronized proteins using poly(ethylene glycol) and electrospraying

, 2014
The fabrication of tailored microparticles for delivery of therapeutics is a challenge relying upon a complex interplay between processing parameters and materials properties.
Bock, Nathalie, Woodruff, Maria A., Dargaville, Tim R.   +2 more
core   +1 more source