Results 31 to 40 of about 203,778 (305)

HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS

Frontiers in Cell and Developmental Biology, 2022
The aberrant translation of a repeat expansion in chromosome 9 open reading frame 72 (C9orf72), the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), results in the accumulation of toxic dipeptide repeat (DPR ...
Giulia del Rosso, Giulia del Rosso, Yari Carlomagno, Tiffany W. Todd, Caroline Y. Jones, Mercedes Prudencio, Mercedes Prudencio, Lillian M. Daughrity, Mei Yue, Karen Jansen-West, Jimei Tong, Wei Shao, Yanwei Wu, Monica Castanedes-Casey, Lilia Tabassian, Björn Oskarsson, Karen Ling, Frank Rigo, Dennis W. Dickson, Dennis W. Dickson, Tso-Pang Yao, Leonard Petrucelli, Leonard Petrucelli, Casey N. Cook, Casey N. Cook, Yong Jie Zhang, Yong Jie Zhang   +26 more
doaj   +1 more source

Inactivation of cloned Na channels expressed in Xenopus oocytes [PDF]

, 1990
This study investigates the inactivation properties of Na channels expressed in Xenopus oocytes from two rat IIA Na channel cDNA clones differing by a single amino acid residue.
Auld, Vanessa J., Davidson, Norman, Dunn, Robert J., Goldin, Alan L., Krafte, Douglas S., Lester, Henry A.   +5 more
core   +1 more source

The Yeast Pan2 Protein Is Required for Poly(A)-binding Protein-stimulated Poly(A)-nuclease Activity [PDF]

Journal of Biological Chemistry, 1996
The removal of the mRNA poly(A) tail in the yeast Saccharomyces cerevisiae is stimulated by the poly(A)-binding protein (Pab1p). A large scale purification of the Pab1p-stimulated poly(A) ribonuclease (PAN) identifies a 76-kDa and two 135-Da polypeptides as candidate enzyme subunits.
R, Boeck, S, Tarun, M, Rieger, J A, Deardorff, S, Müller-Auer, A B, Sachs   +5 more
openaire   +2 more sources

Dependence of endothelial cell growth on substrate-bound fibronectin [PDF]

, 1992
A better understanding of the mechanism of adhesion, spreading and proliferation of human endothelial cells (HEC) on polymeric surfaces may lead to the development of vascular prostheses which allow the formation of an endothelial lining on the luminal ...
Aken, W.G. van, Bantjes, A., Beugeling, T., Dekker, A., Feijen, J., Mourik, J.A. van, Poot, A., Spijkers, J.   +7 more
core   +2 more sources

Rotavirus NSP3 Is a Translational Surrogate of the Poly(A) Binding Protein-Poly(A) Complex [PDF]

Journal of Virology, 2015
ABSTRACT Through its interaction with the 5′ translation initiation factor eIF4G, poly(A) binding protein (PABP) facilitates the translation of 5′-capped and 3′-poly(A)-tailed mRNAs. Rotavirus mRNAs are capped but not polyadenylated, instead terminating in a 3′ GACC motif that is recognized by the viral protein NSP3, which competes ...
Gratia, Matthieu, Sarot, Emeline, Vende, Patrice, Charpilienne, Annie, Hilma Baron, Carolina, Duarte, Mariela, Pyronnet, Stephane, Poncet, Didier   +7 more
openaire   +3 more sources

Structural and Functional Dynamics of Staphylococcus aureus Biofilms and Biofilm Matrix Proteins on Different Clinical Materials

Microorganisms, 2019
Medical device-associated staphylococcal infections are a common and challenging problem. However, detailed knowledge of staphylococcal biofilm dynamics on clinically relevant surfaces is still limited.
Anna K. Hiltunen, Kirsi Savijoki, Tuula A. Nyman, Ilkka Miettinen, Petri Ihalainen, Jouko Peltonen, Adyary Fallarero   +6 more
doaj   +1 more source

Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail [PDF]

Scientific Reports, 2018
AbstractEukaryotic mature mRNAs possess a poly adenylate tail (poly(A)), to which multiple molecules of poly(A)-binding protein C1 (PABPC1) bind. PABPC1 regulates translation and mRNA metabolism by binding to regulatory proteins. To understand functional mechanism of the regulatory proteins, it is necessary to reveal how multiple molecules of PABPC1 ...
Ryoichi Sawazaki, Shunsuke Imai, Mariko Yokogawa, Nao Hosoda, Shin-ichi Hoshino, Muneyo Mio, Kazuhiro Mio, Ichio Shimada, Masanori Osawa   +8 more
openaire   +3 more sources

Identification of a Human Cytoplasmic Poly(A) Nuclease Complex Stimulated by Poly(A)-binding Protein [PDF]

Journal of Biological Chemistry, 2004
The poly(A) tail shortening in mRNA, called deadenylation, is the first rate-limiting step in eukaryotic mRNA turnover, and the polyadenylate-binding protein (PABP) appears to be involved in the regulation of this step. However, the precise role of PABP remains largely unknown in higher eukaryotes.
Naoyuki, Uchida, Shin-Ichi, Hoshino, Toshiaki, Katada   +2 more
openaire   +2 more sources

Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity

Acta Neuropathologica Communications, 2020
A C9orf72 repeat expansion is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis. One of the suggested pathomechanisms is toxicity from dipeptide repeat proteins (DPRs), which are generated via unconventional
Annelies Quaegebeur, Idoia Glaria, Tammaryn Lashley, Adrian M. Isaacs   +3 more
doaj   +1 more source

Paip1 Interacts with Poly(A) Binding Protein through Two Independent Binding Motifs [PDF]

Molecular and Cellular Biology, 2002
The 3' poly(A) tail of eukaryotic mRNAs plays an important role in the regulation of translation. The poly(A) binding protein (PABP) interacts with eukaryotic initiation factor 4G (eIF4G), a component of the eIF4F complex, which binds to the 5' cap structure.
Roy, Guylaine, De Crescenzo, Gregory, Khaleghpour, Kianoush, Kahvejian, Avak, O'Connor-McCourt, Maureen, Sonenberg, Nahum   +5 more
openaire   +4 more sources