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CHASING YOUR OWN POLY(A) TAIL

, 2016
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Beyond simple tails: poly(A) tail-mediated RNA epigenetic regulation

Trends in Biochemical Sciences
The poly(A) tail is an essential structural component of mRNA required for the latter's stability and translation. Recent technologies have enabled transcriptome-wide profiling of the length and composition of poly(A) tails, shedding light on their overlooked regulatory capacities.
Falong Lu
exaly   +3 more sources

Poly(m6A) tails stabilize transcripts

Molecular Cell, 2022
Viegas et al. (2022) discover that in Trypanosoma brucei the poly(A) tails of the variant surface glycoprotein (VSG) transcripts are methylated, a mechanism that stabilizes these transcripts and ensures protection against the immune response in mammals.
Guillaume, Lavergne, Jean-Yves, Roignant
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Control of poly(A) tail length

WIREs RNA, 2010
AbstractPoly(A) tails have long been known as stable 3′ modifications of eukaryotic mRNAs, added during nuclear pre‐mRNA processing. It is now appreciated that this modification is much more diverse: A whole new family of poly(A) polymerases has been discovered, and poly(A) tails occur as transient destabilizing additions to a wide range of different ...
Eckmann, C., Rammelt, C., Wahle, E.
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Poly(A) tails: longer is not always better

Nature Structural & Molecular Biology, 2017
Deadenylation of mRNAs is generally associated with translational inhibition and mRNA decay. A study now reports that, unexpectedly, highly expressed genes tend to have shorter poly(A) tails and suggests that poly(A) tails can be 'pruned', generating a 30-nucleotide-biased phased distribution, likely due to protection by poly(A)-binding proteins.
Luciana A, Castellano, Ariel A, Bazzini
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Measuring the Length of Poly(A) Tails

Cold Spring Harbor Protocols, 2015
Adenylation status has an important role in the regulation of mRNA metabolism: mRNAs are deadenylated before degradation, microRNAs (miRNAs) can cause deadenylation, and the poly(A) length of certain mRNAs is regulated during development. This protocol describes methods that can be used to measure the poly(A) tail length of specific mRNAs.
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Fractionation of mRNA Based on the Length of the Poly(A) Tail

2010
Poly(A) tail length plays an important role in mRNA stability and translational control. Poly(A) fractionation is a very powerful technique to separate mRNAs according to the length of the poly(A) tail. Poly(A) fractionation can be used to detect small changes in poly(A) tail length or to prepare samples for microarray analysis.
Hedda A, Meijer, Cornelia H, de Moor
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The Determination of “Head-Head” and “Tail-Tail” Structures in Poly(Isoprene)S

Rubber Chemistry and Technology, 1972
Abstract Pyrolysis-gas chromatography has indicated the presence of head-head structures in free radical initiated poly(isoprene)s. Microozonolysis has confirmed the presence of both head-head (15-20 per cent) and tail-tail (4-7 per cent) structures in these polymers.
Marjorie J. Hackathorn, M. J. Brock
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Poly(A)-Tailed Universal Reverse Transcription

2009
Zheng’ laboratory from the Beijing Institute of Radiation Medicine (Beijing, People’s Republic of China) and Yan’s laboratory from the Department of Physiology and Cell Biology, the University of Nevada School of Medicine (Reno, NV, USA) independently established the Poly(A)-Tailed Universal Reverse Transcription technique, a simple method to detect ...
Zhiguo Wang, Baofeng Yang
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Poly(A) tail synthesis and regulation: recent structural insights

Current Opinion in Structural Biology, 2002
Polyadenylation at the 3' ends of mRNAs is critical to the translation and stability of the messages. Recently determined structures of poly(A) polymerase, U1A and domains of the poly(A)-binding protein provide a framework for understanding the synthesis and regulation of the poly(A) tail.
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