Results 211 to 220 of about 285,813 (286)

Heat Shock Responsive Gene Expression Modulated by mRNA Poly(A) Tail Length. [PDF]

Front Plant Sci, 2020
Wu X, Wang J, Wu X, Hong Y, Li QQ.
europepmc   +1 more source

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Characterization of poly(A) and poly(T) tail lengths in plasmid DNA by liquid chromatography high-resolution mass spectrometry. [PDF]

Anal Bioanal Chem
Al Turihi N, Allouche D, Quéré M, Scuiller M, Legastelois I.   +4 more
europepmc   +1 more source

Phosphodiester modifications in mRNA poly(A) tail prevent deadenylation without compromising protein expression. [PDF]

RNA, 2020
Strzelecka D, Smietanski M, Sikorski PJ, Warminski M, Kowalska J, Jemielity J.   +5 more
europepmc   +1 more source

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

An engineered surrogate poly(A) tail to wag translation initiation. [PDF]

Cell Res
Lohse S, Weber W.
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Radical‐Mediated, Substrate‐Independent Fabrication of Hybrid Solid–Hydrogel Materials With Tunable Crosslinking: An Initiator‐ and Crosslinker‐Free Approach

Advanced Science, EarlyView.
This work introduces a substrate‐independent, reagent‐free plasma strategy that forms radical‐rich interlayers for covalent hydrogel attachment without initiators or crosslinkers. The long‐lived radicals drive in situ gelation, creating robust, cytocompatible hybrid solid–hydrogel constructs across diverse substrates.
Ghazal Shineh, Azin Khodaei, Pardis Keikhosravani, Masoud Zhianmanesh, Yiyun Xia, Aaron Gilmour, Sina Naficy, Andrea Guzina, Daniella Bianchi, Khoon S. Lim, Fariba Dehghani, Saber Amin Yavari, Marcela Bilek, Giselle C. Yeo, Behnam Akhavan   +14 more
wiley   +1 more source

Concerted action of ataxin-2 and PABPC1-bound mRNA poly(A) tail in the formation of stress granules. [PDF]

Nucleic Acids Res
Yamagishi R, Inagaki H, Suzuki J, Hosoda N, Sugiyama H, Tomita K, Hotta T, Hoshino SI.   +7 more
europepmc   +1 more source

Rbm24 controls poly(A) tail length and translation efficiency of crystallin mRNAs in the lens via cytoplasmic polyadenylation. [PDF]

Proc Natl Acad Sci U S A, 2020
Shao M, Lu T, Zhang C, Zhang YZ, Kong SH, Shi DL.   +5 more
europepmc   +1 more source