Results 141 to 150 of about 61,707 (214)

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source

Excessive exercise elicits poly (ADP-ribose) Polymerase-1 activation and global protein PARylation driving muscle dysfunction and performance impairment. [PDF]

Mol Metab
Crisol BM, Rocha MB, Franco B, Morelli AP, Katashima CK, Junior SJA, Carneiro FS, Braga RR, Brícola RS, de Azambuja G, Costa RG, Esteves AM, Mori MA, Oliveira MCG, Cintra DE, Pauli JR, Larsen FJ, da Silva ASR, Ropelle ER.   +18 more
europepmc   +1 more source

Uranium directly interacts with the DNA repair protein poly (ADP-ribose) polymerase 1. [PDF]

Toxicol Appl Pharmacol, 2021
Zhou X, Xue B, Medina S, Burchiel SW, Liu KJ.   +4 more
europepmc   +1 more source

Abscopal Effect in Radiation Therapy: The Immune Mechanisms and Clinical Advances

MedComm, Volume 7, Issue 9, September 2026.
The schematic outlines the key events of the abscopal effect. (Ignition) Local radiotherapy (RT) induces the release of immunogenic signals from the tumor, leading to dendritic cell (DC) activation. (Orchestration) In the tumor‐draining lymph node (TDLN), DCs prime naive T cells into cytotoxic T lymphocytes (CTLs), a process modulated by regulatory T ...
Yihong Dong, Moran Chen, Xupeng Hou, Xiaoya Tang, Xiaoli Yu, Jing Liu   +5 more
wiley   +1 more source

Epstein-Barr Virus Viral Processivity Factor EA-D Facilitates Virus Lytic Replication by Inducing Poly(ADP-Ribose) Polymerase 1 Degradation. [PDF]

J Virol, 2022
Lee S, Kim J, Chung WC, Han JH, Song MJ.
europepmc   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors in Diabetic Retinopathy: An Attractive but Elusive Choice for Drug Development. [PDF]

Pharmaceutics
Pöstyéni E, Gábriel R, Kovács-Valasek A.   +2 more
europepmc   +1 more source

Dual‐view scout scans with deep learning for ultra‐low dose attenuation correction in PET

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Accurate attenuation correction (AC) is essential for quantitative positron emission tomography (PET). Conventional CT‐based AC provides reliable attenuation (μ‐) maps but adds radiation, introduces PET/CT misalignment artifacts, and is unavailable on stand‐alone PET systems.
Florence M. Muller, Margaret E. Daube‐Witherspoon, Michael J. Parma, Amy E. Perkins, Peter B. Noël, Christian Vanhove, Stefaan Vandenberghe, Joel S. Karp   +7 more
wiley   +1 more source

Imaging poly(ADP-ribose) polymerase-1 (PARP1) <i>in vivo</i> with ¹⁸F-labeled brain penetrant positron emission tomography (PET) ligand. [PDF]

Acta Pharm Sin B
Zhou X, Chen J, Patel JS, Ran W, Li Y, Van RS, Ibrahim MMH, Zhao C, Gao Y, Rong J, Chaudhary AF, Li G, Hu J, Davenport AT, Daunais JB, Shao Y, Ran C, Collier TL, Haider A, Schuster DM, Levey AI, Wang L, Corfas G, Liang SH.   +23 more
europepmc   +1 more source

Hypoxia-inducible factor-1α and poly [ADP ribose] polymerase 1 cooperatively regulate Notch3 expression under hypoxia via a noncanonical mechanism. [PDF]

J Biol Chem, 2022
Nakamura H, Sekine H, Kato H, Masai H, Gradin K, Poellinger L.   +5 more
europepmc   +1 more source