Results 71 to 80 of about 30,320,198 (205)

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

Nature Communications, 2019
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates local chromatin relaxation and the recruitment of DNA repair factors at double strand breaks site (DSBs). Here the authors reveal that PARP-1 acts as a critical regulator of DNA end resection of DSBs.
Marie-Christine Caron, Ajit K. Sharma, Julia O’Sullivan, Logan R. Myler, Maria Tedim Ferreira, Amélie Rodrigue, Yan Coulombe, Chantal Ethier, Jean-Philippe Gagné, Marie-France Langelier, John M. Pascal, Ilya J. Finkelstein, Michael J. Hendzel, Guy G. Poirier, Jean-Yves Masson   +14 more
doaj   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Cooperative nucleic acid binding by Poly ADP-ribose polymerase 1

Scientific Reports
Poly (ADP)-ribose polymerase 1 (PARP1) is an abundant nuclear protein well-known for its role in DNA repair yet also participates in DNA replication, transcription, and co-transcriptional splicing, where DNA is undamaged.
Manana Melikishvili, Michael G. Fried, Yvonne N. Fondufe-Mittendorf   +2 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

Nature Communications, 2019
Vascular calcification is a hallmark of end stage renal disease. Here, Cheng et al. show that poly(ADP-ribose) polymerase (PARP) activity is increased in calcified arteries in patients and uremic rats, and that PARP1 promotes vascular calcification by ...
Cheng Wang, Wenjing Xu, Jie An, Minglu Liang, Yiqing Li, Fengxiao Zhang, Qiangsong Tong, Kai Huang   +7 more
doaj   +1 more source

Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors

, 2016
Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful chemopotentiators of temozolomide and topotecan in both A549 and LoVo cell lines.
Jianke Li (219587), David R. Newell (129326), Brian W. Eastman (3016296), A. Hilary Calvert (2219308), Stephen E. Webber (2471281), Roger J. Griffin (129311), Anne Ekker (3016311), Xiao-Hong Yu (2134060), Donald J. Skalitzky (3016314), Bernard T. Golding (129309), Zdenek Hostomsky (3016299), Nicola J. Curtin (351064), Joseph T. Marakovits (3016305), Robert Almassy (3016302), Karen A. Maegley (3016308)   +14 more
core   +1 more source

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Interaction between Poly(ADP-ribose) polymerase-1 and α-synuclein pathology in Parkinson’s disease

Frontiers in Neuroscience
Poly(ADP-ribose) polymerase-1 (PARP-1) activation and α-synuclein (α-syn) aggregation are neuropathological hallmarks of Parkinson’s disease. This review aims to summarize the extensive interplay between these two factors.
Peng Zhang, Qinghua Li, Qinghua Li, Qinghua Li, Qinghua Li, Xiaojun Diao, Sihao Zeng   +6 more
doaj   +1 more source

Imaging poly(ADP-ribose) polymerase-1 (PARP1) in vivo with 18F-labeled brain penetrant positron emission tomography (PET) ligand [PDF]

Poly(ADP-ribose) polymerase 1 (PARP1) is a multifunctional protein involved in diverse cellular functions, notably DNA damage repair. Pharmacological inhibition of PARP1 holds potential therapeutic benefits for various pathologies.
Richard S. , Van, Mostafa M. H., Ibrahim, Yabiao, Gao, April T., Davenport, Allan, Levey, Chunyu, Zhao, Gabriel, Corfas, Jiahui, Chen, Thomas L., Collier, Lu , Wang, James D. , Daunais, Guocong, Li, Yihan, Shao, Junqi, Hu, Xin, Zhou, Jimmy S., Patel, David M., Schuster, Steven H., Liang, Yinlong, Li, Ahmad F., Chaudhary, Chongzhao, Ran, Jian, Rong, Wenqing, Ran, Ahmed, Haider   +23 more
core   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source