Results 241 to 250 of about 106,568 (297)

Next-Generation Sequencing-Guided Treatment of BRCA2-Mutant Metastatic Uterine Leiomyosarcoma With Poly(ADP-ribose) Polymerase Inhibitor Therapy. [PDF]

JCO Precis Oncol
Kirkendoll C, Mansour R, Gaddam SJ.
europepmc   +1 more source

Antioxidant Defenses and Poly(ADP-Ribose) Polymerase (PARP) Activity Provide "Radioresilience" Against Ionizing Radiation-Induced Stress in Dwarf Bean Plants. [PDF]

Antioxidants (Basel)
Hay Mele B, Bianchi AR, Guerretti V, Pugliese M, De Maio A, Arena C.   +5 more
europepmc   +1 more source

The PARPscore system using poly (ADP-ribose) polymerase (PARP) family features and tumor immune microenvironment in glioma. [PDF]

Discov Oncol
Zhang C, Feng J, Zhou X, Zhang J, Tao C, Zhou H.   +5 more
europepmc   +1 more source

Clinical Outcomes of Poly(ADP-Ribose) Polymerase Inhibitors as Maintenance Therapy in Patients with Ovarian Cancer in the Southeastern Region of Korea. [PDF]

Curr Oncol
Ha HI, Yoon HJ, Song C, Kim ET, Suh DS, Kim KH, Na YJ, Song YJ.   +7 more
europepmc   +1 more source

Poly(ADP-Ribose) Polymerase (PARP) Inhibitors for Cancer Therapy: Advances, Challenges, and Future Directions. [PDF]

Biomolecules
Bondar D, Karpichev Y.
europepmc   +1 more source

Ivosidenib Confers BRCAness Phenotype and Synthetic Lethality to Poly (ADP-Ribose) Polymerase Inhibition in <i>BRCA1/2</i>-Proficient Cancer Cells. [PDF]

Biomedicines
Zhou D, Liu W, Zhang Y, Li C.
europepmc   +1 more source

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Trapping Poly(ADP-Ribose) Polymerase

The Journal of Pharmacology and Experimental Therapeutics, 2015
Recent findings indicate that a major mechanism by which poly(ADP-ribose) polymerase (PARP) inhibitors kill cancer cells is by trapping PARP1 and PARP2 to the sites of DNA damage. The PARP enzyme-inhibitor complex "locks" onto damaged DNA and prevents DNA repair, replication, and transcription, leading to cell death.
Yuqiao, Shen, Mika, Aoyagi-Scharber, Bing, Wang   +2 more
openaire   +2 more sources

Poly(ADP-Ribose) Polymerase Inhibitors

Current Medicinal Chemistry, 2003
Poly(ADP-ribose) polymerase-1 (PARP-1) is the principal member of the PARP enzyme family consisting of PARP-1 and several recently identified novel poly(ADP-ribosyl)ating enzymes. PARP-1 functions as a DNA damage sensor and signalling molecule. Upon binding to DNA breaks, activated PARP cleaves NAD(+) into nicotinamide and ADP-ribose and polymerizes ...
Garry J, Southan, Csaba, Szabó
openaire   +2 more sources

Apoptosis in the Absence of Poly- (ADP-ribose) Polymerase

Biochemical and Biophysical Research Communications, 1997
Cleavage of poly-(ADP-ribose) polymerase is a process occurring early during the execution phase of apoptosis. Although in many experimental systems PARP cleavage indicates a point of no return, the significance of this proteolytic step for apoptosis remains unclear.
M, Leist, B, Single, G, Künstle, C, Volbracht, H, Hentze, P, Nicotera   +5 more
openaire   +2 more sources