Results 121 to 130 of about 1,124 (169)
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Poly(ADP-ribosyl)ation and stroke
Pharmacological Research, 2005Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity affords substantial neuroprotection ...
Alberto Chiarugi
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Poly(ADP‐Ribosyl)ation, Genomic Instability, and Longevity
Annals of the New York Academy of Sciences, 2000 Abstract: Poly(ADP‐ribosyl)ation is a DNA strandbreak‐driven posttranslational modification of nuclear proteins that is catalyzed by poly(ADP‐ribose) polymerase‐1 (PARP‐1), with NAD+ serving as substrate. Recently, additional PARP isoforms were described that seem to account for a minor fraction of cellular poly(ADP‐ribose) synthesis.
ALEXANDER BÜRKLE, Burkle A
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The role of poly(ADP-ribosyl)ation in epigenetic events
The International Journal of Biochemistry & Cell Biology, 2009 Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone modifications, remodeling of nucleosomes and higher order chromatin modifications. In the framework of chromatin remodeling activities, the poly(ADP-ribosyl)ation of nuclear proteins catalyzed by PARPs, particularly PARP-1 and PARP-2, plays a ...
Quénet, Delphine +3 more
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Role of poly(ADP-ribosyl)ation during human spermatogenesis
Fertility and Sterility, 2006Genomic stability of cells is known to be linked to their poly(ADP-ribosyl)ation capacity. We aimed to demonstrate, for the first time, the patterns of poly(ADP-ribosyl)ation during human spermatogenesis.Retrospective case-control study.Teaching hospital.Azoospermic men who underwent testicular biopsy for sperm recovery.Testicular biopsy evaluation by ...
Batia Bar-Shira Maymon +2 more
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Modulation of chromatin structure by poly(ADP-ribosyl)ation.
Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988 Poly(ADP-ribose) polymerase is a nuclear enzyme that is highly conserved in eucaryotes. Its activity is totally dependent on the presence of DNA containing single or double stranded breaks. We have shown that this activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosy)ation of histone H1.
G, de Murcia, A, Huletsky, G G, Poirier
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Poly(ADP-ribosyl)ation in carcinogenesis
Molecular Aspects of Medicine, 2013Cancer develops through diverse genetic, epigenetic and other changes, so-called 'multi-step carcinogenesis', and each cancer harbors different alterations and properties. Here in this article we review how poly(ADP-ribosyl)ation is involved in multi-step and diverse pathways of carcinogenesis.
Mitsuko, Masutani, Hiroaki, Fujimori
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Poly(ADP-ribosyl)ation in plants
Trends in Plant Science, 2011Poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolases (PARGs) are the main enzymes responsible for the post-translational modification known as poly(ADP-ribosyl)ation. These enzymes play important roles in genotoxic stress tolerance and DNA repair, programmed cell death, transcription, and cell cycle control in animals.
Amy G, Briggs, Andrew F, Bent
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Poly(ADP-ribosyl)ation and aging
Experimental Gerontology, 2004Poly(ADP-ribosyl)ation is a DNA strand break-driven post-translational modification of proteins catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1), with NAD+ serving as substrate. Poly(ADP-ribosyl)ation is triggered by DNA strand breaks, is functionally associated with DNA repair pathways and is a survival factor for cells under low to moderate levels
Alexander, Bürkle +2 more
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Poly(ADP-ribosyl)ation studies in situ
Analytical Biochemistry, 1986We have studied the poly(ADP-ribosyl)ation of nuclear proteins in situ by examining the incorporation of [3H]NAD-derived ADP-ribose into polymers. We have devised a way to deliver [3H]NAD to cells growing in vitro, and we have determined the kinetics of uptake and incorporation into nuclear proteins using this delivery system.
D M, Duhl, L S, Hnilica
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50Years of poly(ADP-ribosyl)ation
Molecular Aspects of Medicine, 2013The seminal paper published in 1963 by Chambon, Weil and Mandel reporting a new NAD-dependent protein modification now known as poly(ADP-ribosyl)ation (PARylation) marked the launch of a new era in both protein research and cell biology. In the coming decades, the identity, biochemical characteristics and regulation of enzymes responsible for the ...
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