Results 171 to 180 of about 6,825 (206)

A role for poly(ADP-ribosyl)ation in DNA methylation

Biochemistry and Cell Biology, 2003
The aberrant DNA methylation of promoter regions of housekeeping genes leads to gene silencing. Additional epigenetic events, such as histone methylation and acetylation, also play a very important role in the definitive repression of gene expression by DNA methylation.
ZARDO, GIUSEPPE, REALE, Anna, DE MATTEIS, Giovanna, BUONTEMPO S, CAIAFA, Paola   +4 more
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The role of poly(ADP-ribosyl)ation in epigenetic events

The International Journal of Biochemistry & Cell Biology, 2009
Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone modifications, remodeling of nucleosomes and higher order chromatin modifications. In the framework of chromatin remodeling activities, the poly(ADP-ribosyl)ation of nuclear proteins catalyzed by PARPs, particularly PARP-1 and PARP-2, plays a ...
Quénet, Delphine, El Ramy, Rosy, Schreiber, Valérie, Dantzer, Françoise   +3 more
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Poly(ADP‐Ribosyl)ation, Genomic Instability, and Longevity

Annals of the New York Academy of Sciences, 2000
Abstract: Poly(ADP‐ribosyl)ation is a DNA strandbreak‐driven posttranslational modification of nuclear proteins that is catalyzed by poly(ADP‐ribose) polymerase‐1 (PARP‐1), with NAD+ serving as substrate. Recently, additional PARP isoforms were described that seem to account for a minor fraction of cellular poly(ADP‐ribose) synthesis.
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Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation

2007
This chapter emphasizes that along the chain of events that induce DNA methylation-dependent chromatin condensation, a post-synthetic modification other than histone acetylation, poly(ADP-ribosyl)ation, participates in the establishment and maintenance of methylation-free regions of chromatin.
REALE, Anna, ZARDO, GIUSEPPE, M. MALANGA, J. ZLATANOVA, CAIAFA, Paola   +4 more
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Chromosomal protein poly(ADP-ribosyl)ation in pancreatic nucleosomes

Canadian Journal of Biochemistry, 1982
When pancreatic chromatin fragments were prepared and resolved in the presence of 80 mM NaCl, endogenous poly(ADP-ribose) polymerase activity was found to be maximal in nucleosome periodicities of four to five units and did not respond to any further increases in nucleosomal architecture.
R J, Aubin, V T, Dam, J, Miclette, Y, Brousseau, G G, Poirier   +4 more
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[45] Overview of poly(ADP-ribosyl)ation

1984
Publisher Summary This chapter provides an overview of poly(ADP-ribosyl)ation. The formation of poly(ADP-ribose) by chromatin enzymes is actually initiated by ADP-ribosylation on chromatin proteins. The ADP-ribosylation reaction is catalyzed by enzymes which transfer the ADP-ribose residue of NAD + to various acceptor proteins.
Mark E. Smulson, Takashi Sugimura
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Genomic Maintenance: The p53 Poly(ADP-ribosyl)ation Connection

Science's STKE, 2007
The integrity of the genome in higher eukaryotes, as well as the modulation of its complex structure and functions, is exquisitely regulated. This genomic regulation occurs as a function of time in a very sophisticated and elaborate biological process called cell cycle progression, resulting in cell division, and is also controlled by a highly ...
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Poly(ADP-ribosyl)ation in asthma and other lung diseases

Pharmacological Research, 2005
Inhibition of poly(ADP-ribosyl)ation in oxidative stress-related pathologies has recently emerged as a very effective anti-inflammatory intervention in animal models of arthritis, colitis, diabetes and shock. Recent data from three laboratories also support the role of poly(ADP-ribose) polymerase-1 (PARP-1) activation in asthma.
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The role of poly(ADP-ribosyl)ation

1997
S L, Oei, J, Griesenbeck, M, Schweiger
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Modulation of chromatin structure by poly(ADP-ribosyl)ation.

Biochemistry and cell biology = Biochimie et biologie cellulaire, 1988
Poly(ADP-ribose) polymerase is a nuclear enzyme that is highly conserved in eucaryotes. Its activity is totally dependent on the presence of DNA containing single or double stranded breaks. We have shown that this activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosy)ation of histone H1.
G, de Murcia, A, Huletsky, G G, Poirier
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