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Poly(ADP-ribosyl)ation and aging
Experimental Gerontology, 2004Poly(ADP-ribosyl)ation is a DNA strand break-driven post-translational modification of proteins catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1), with NAD+ serving as substrate. Poly(ADP-ribosyl)ation is triggered by DNA strand breaks, is functionally associated with DNA repair pathways and is a survival factor for cells under low to moderate levels
Alexander, Bürkle +2 more
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Poly(ADP-ribosyl)ation in carcinogenesis
Molecular Aspects of Medicine, 2013Cancer develops through diverse genetic, epigenetic and other changes, so-called 'multi-step carcinogenesis', and each cancer harbors different alterations and properties. Here in this article we review how poly(ADP-ribosyl)ation is involved in multi-step and diverse pathways of carcinogenesis.
Mitsuko, Masutani, Hiroaki, Fujimori
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Poly(ADP-ribosyl)ation in plants
Trends in Plant Science, 2011Poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribose) glycohydrolases (PARGs) are the main enzymes responsible for the post-translational modification known as poly(ADP-ribosyl)ation. These enzymes play important roles in genotoxic stress tolerance and DNA repair, programmed cell death, transcription, and cell cycle control in animals.
Amy G, Briggs, Andrew F, Bent
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Effect of zinc on cellular poly(ADP-ribosyl)ation capacity [PDF]
Experimental Gerontology, 2008 Poly(ADP-ribosyl)ation is a posttranslational protein modification, which is catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1) and plays a role in DNA repair and maintenance of genomic stability. A decrease in cellular poly(ADP-ribosyl)ation has been implicated in the aging process.
George Dedoussis +2 more
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Role of poly(ADP-ribosyl)ation during human spermatogenesis
Fertility and Sterility, 2006Genomic stability of cells is known to be linked to their poly(ADP-ribosyl)ation capacity. We aimed to demonstrate, for the first time, the patterns of poly(ADP-ribosyl)ation during human spermatogenesis.Retrospective case-control study.Teaching hospital.Azoospermic men who underwent testicular biopsy for sperm recovery.Testicular biopsy evaluation by ...
Malka Cohen-Armon, Sandra E Kleiman
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Poly(ADP-ribosyl)ation studies in situ
Analytical Biochemistry, 1986We have studied the poly(ADP-ribosyl)ation of nuclear proteins in situ by examining the incorporation of [3H]NAD-derived ADP-ribose into polymers. We have devised a way to deliver [3H]NAD to cells growing in vitro, and we have determined the kinetics of uptake and incorporation into nuclear proteins using this delivery system.
D M, Duhl, L S, Hnilica
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50Years of poly(ADP-ribosyl)ation
Molecular Aspects of Medicine, 2013The seminal paper published in 1963 by Chambon, Weil and Mandel reporting a new NAD-dependent protein modification now known as poly(ADP-ribosyl)ation (PARylation) marked the launch of a new era in both protein research and cell biology. In the coming decades, the identity, biochemical characteristics and regulation of enzymes responsible for the ...
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PARPing for balance in the homeostasis of poly(ADP-ribosyl)ation
Seminars in Cell & Developmental Biology, 2017Despite more than 50 years of research, the vast majority of the biology of poly(ADP-ribosyl)ation (PARylation) still remains a gross mystery. Originally described to be a part of the DNA repair machinery, poly(ADP-ribose) (PAR) is synthesized immediately by poly(ADP-ribose) polymerases (PARPs, also known as ARTDs) upon DNA damage and then rapidly ...
Harald Schuhwerk +3 more
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Physiology and pathophysiology of poly(ADP‐ribosyl)ation *
BioEssays, 2001AbstractOne of the immediate eukaryotic cellular responses to DNA breakage is the covalent post‐translational modification of nuclear proteins with poly(ADP‐ribose) from NAD+ as precursor, mostly catalysed by poly(ADP‐ribose) polymerase‐1 (PARP‐1). Recently several other polypeptides have been shown to catalyse poly(ADP‐ribose) formation.
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The role of poly(ADP-ribosyl)ation in the adaptive response
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1996An involvement of the poly(ADP-ribosyl)ation system in the expression of the adaptive response has been demonstrated with inhibitors of the nuclear enzyme poly(ADP-ribose) polymerase. This enzyme is a key component of a reaction cycle in chromatin, involving dynamic synthesis and degradation of variably sized ADP-ribose polymers in response to DNA ...
Kleczkowska HE, Althaus FR
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