Results 161 to 170 of about 3,094 (198)
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Poly(ADP-ribosyl)ation studies in situ
Analytical Biochemistry, 1986We have studied the poly(ADP-ribosyl)ation of nuclear proteins in situ by examining the incorporation of [3H]NAD-derived ADP-ribose into polymers. We have devised a way to deliver [3H]NAD to cells growing in vitro, and we have determined the kinetics of uptake and incorporation into nuclear proteins using this delivery system.
D M, Duhl, L S, Hnilica
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Role of poly(ADP-ribosyl)ation during human spermatogenesis
Fertility and Sterility, 2006Genomic stability of cells is known to be linked to their poly(ADP-ribosyl)ation capacity. We aimed to demonstrate, for the first time, the patterns of poly(ADP-ribosyl)ation during human spermatogenesis.Retrospective case-control study.Teaching hospital.Azoospermic men who underwent testicular biopsy for sperm recovery.Testicular biopsy evaluation by ...
Sandra Edith Kleiman +2 more
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50Years of poly(ADP-ribosyl)ation
Molecular Aspects of Medicine, 2013The seminal paper published in 1963 by Chambon, Weil and Mandel reporting a new NAD-dependent protein modification now known as poly(ADP-ribosyl)ation (PARylation) marked the launch of a new era in both protein research and cell biology. In the coming decades, the identity, biochemical characteristics and regulation of enzymes responsible for the ...
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PARPing for balance in the homeostasis of poly(ADP-ribosyl)ation
Seminars in Cell & Developmental Biology, 2017Despite more than 50 years of research, the vast majority of the biology of poly(ADP-ribosyl)ation (PARylation) still remains a gross mystery. Originally described to be a part of the DNA repair machinery, poly(ADP-ribose) (PAR) is synthesized immediately by poly(ADP-ribose) polymerases (PARPs, also known as ARTDs) upon DNA damage and then rapidly ...
Harald Schuhwerk +3 more
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Physiology and pathophysiology of poly(ADP‐ribosyl)ation *
BioEssays, 2001AbstractOne of the immediate eukaryotic cellular responses to DNA breakage is the covalent post‐translational modification of nuclear proteins with poly(ADP‐ribose) from NAD+ as precursor, mostly catalysed by poly(ADP‐ribose) polymerase‐1 (PARP‐1). Recently several other polypeptides have been shown to catalyse poly(ADP‐ribose) formation.
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The role of poly(ADP-ribosyl)ation in the adaptive response
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1996An involvement of the poly(ADP-ribosyl)ation system in the expression of the adaptive response has been demonstrated with inhibitors of the nuclear enzyme poly(ADP-ribose) polymerase. This enzyme is a key component of a reaction cycle in chromatin, involving dynamic synthesis and degradation of variably sized ADP-ribose polymers in response to DNA ...
Kleczkowska HE, Althaus FR
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A role for poly(ADP-ribosyl)ation in DNA methylation
Biochemistry and Cell Biology, 2003The aberrant DNA methylation of promoter regions of housekeeping genes leads to gene silencing. Additional epigenetic events, such as histone methylation and acetylation, also play a very important role in the definitive repression of gene expression by DNA methylation.
ZARDO, GIUSEPPE +4 more
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The role of poly(ADP-ribosyl)ation in epigenetic events
The International Journal of Biochemistry & Cell Biology, 2009Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone modifications, remodeling of nucleosomes and higher order chromatin modifications. In the framework of chromatin remodeling activities, the poly(ADP-ribosyl)ation of nuclear proteins catalyzed by PARPs, particularly PARP-1 and PARP-2, plays a ...
Quénet, Delphine +3 more
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Poly(ADP‐Ribosyl)ation, Genomic Instability, and Longevity
Annals of the New York Academy of Sciences, 2000Abstract: Poly(ADP‐ribosyl)ation is a DNA strandbreak‐driven posttranslational modification of nuclear proteins that is catalyzed by poly(ADP‐ribose) polymerase‐1 (PARP‐1), with NAD+ serving as substrate. Recently, additional PARP isoforms were described that seem to account for a minor fraction of cellular poly(ADP‐ribose) synthesis.
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Inhibition of Poly(ADP-Ribosyl)ation Allows DNA Hypermethylation
2007This chapter emphasizes that along the chain of events that induce DNA methylation-dependent chromatin condensation, a post-synthetic modification other than histone acetylation, poly(ADP-ribosyl)ation, participates in the establishment and maintenance of methylation-free regions of chromatin.
REALE, Anna +4 more
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