Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets [PDF]
Nature Communications, 2018 Poly ADP-ribosylation (PARylation) is a highly dynamic post-translation protein modification, but most methods only detect stable PARylation events. Here the authors develop a split-GFP-based sensor for PARylation detection in live cells and use it to ...
Dragomir B Krastev +2 more
exaly +7 more sources
PARylation promotes acute kidney injury via RACK1 dimerization-mediated HIF-1α degradation [PDF]
Acta Pharmaceutica Sinica BPoly(ADP-ribosyl)ation (PARylation) is a specific form of post-translational modification (PTM) predominantly triggered by the activation of poly-ADP-ribose polymerase 1 (PARP1).
Juan Jin, Yujie Liu, Ju-Tao Yu
exaly +5 more sources
PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination [PDF]
Cell Reports, 2021 Summary: The function of poly(ADP-ribosyl) polymerase 1 (PARP1) in myelination and remyelination of the central nervous system (CNS) remains enigmatic.
Yan Wang, Yanhong Zhang, Sheng Zhang
exaly +8 more sources
Covalent PARylation of DNA base excision repair proteins regulates DNA demethylation [PDF]
Nature CommunicationsThe intracellular ATP-ribosyltransferases PARP1 and PARP2, contribute to DNA base excision repair (BER) and DNA demethylation and have been implicated in epigenetic programming in early mammalian development.
Cathrine B Vågbø +2 more
exaly +9 more sources
TET-mediated DNA hydroxymethylation is negatively influenced by the PARP-dependent PARylation [PDF]
Epigenetics & Chromatin, 2022 Background Poly(ADP-ribosyl)ation (PARylation), a posttranslational modification introduced by PARP-1 and PARP-2, has first been implicated in DNA demethylation due to its role in base excision repair. Recent evidence indicates a direct influence of PARP-
Anja Tolić +12 more
doaj +6 more sources
Functions of PARylation in DNA Damage Repair Pathways
Genomics, Proteomics and Bioinformatics, 2016 Protein poly ADP-ribosylation (PARylation) is a widespread post-translational modification at DNA lesions, which is catalyzed by poly(ADP-ribose) polymerases (PARPs).
Huiting Wei, Xiaochun Yu
exaly +6 more sources
PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1 [PDF]
Cell Reports, 2023 Summary: The nucleolytic processing (resection) of a DNA double-strand break (DSB) is a critical step to repair the lesion by homologous recombination (HR).
Samuele Lodovichi +3 more
doaj +6 more sources
Nature Communications, 2021 TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilization ...
Yilun Sun, Jiji Chen, Shar-Yin N Huang
exaly +2 more sources
Inputs and outputs of poly(ADP-ribosyl)ation: relevance to oxidative stress [PDF]
Redox Biology, 2017 Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family.
Hegedűs, Csaba, Virág, László
core +3 more sources
SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis [PDF]
eLifeRNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators.
Kira Breunig +18 more
doaj +4 more sources