Mammalian N1-adenosine PARylation is a reversible DNA modification
Nature Communications, 2022 Poly-ADP-ribosylation (PARylation) is a well-known posttranslational modification of proteins. Here the authors show that beyond proteins also mammalian single-stranded DNA is PARylated in vitro and in vivo.
Michael U Musheev +2 more
exaly +5 more sources
A Double-Edged Sword: The Two Faces of PARylation [PDF]
International Journal of Molecular Sciences, 2022 Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage. Originally, studies on PARylation were confined to PARP-1 activation in the DNA repair pathway.
Seong-Hoon Park +2 more
exaly +4 more sources
PARylation-mediated post-transcriptional modifications in cancer immunity and immunotherapy [PDF]
Frontiers in ImmunologyPoly-ADP-ribosylation (PARylation) is a post-translational modification in which ADP-ribose is added to substrate proteins. PARylation is mediated by a superfamily of ADP-ribosyl transferases known as PARPs and influences a wide range of cellular ...
Kazuya Matsumoto +2 more
doaj +4 more sources
PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation [PDF]
Cancers, 2020 Transcription is a multistep, tightly regulated process. During transcription initiation, promoter recognition and pre-initiation complex (PIC) formation take place, in which dynamic recruitment or exchange of transcription activators occur. The precise coordination of the recruitment and removal of transcription factors, as well as chromatin ...
Barbara Borsos +2 more
exaly +6 more sources
5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme [PDF]
Oncotarget, 2015 5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression ...
CAIAFA, Paola +3 more
core +20 more sources
SPINDOC binds PARP1 to facilitate PARylation [PDF]
Nature Communications, 2021 SPINDOC is known to interact with Spindlin1 (SPIN1), a histone code effector protein. Here, the authors show that SPINDOC is distributed between two distinct protein complexes, one comprising SPIN1 and the other one with PARP1.
Fen Yang +8 more
doaj +3 more sources
The role of histone modifications in transcription regulation upon DNA damage. [PDF]
FEBS LettThis review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Kolady AJ, Wang S.
europepmc +2 more sources
Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation
Acta Pharmaceutica Sinica B, 2019 The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role ...
Jing Lu +11 more
doaj +3 more sources
Ubiquitination and PARylation cross-talk about immunity [PDF]
Molecular Plant, 2021 Marco Trujillo
openalex +4 more sources
PARP1 mediated PARylation contributes to myogenic progression and glucocorticoid transcriptional response [PDF]
Cell Death Discovery, 2023 Abstract The ADP-ribosyltransferase, PARP1 enzymatically generates and applies the post-translational modification, ADP-Ribose (ADPR). PARP1 roles in genome maintenance are well described, but recent work highlights roles in many fundamental processes including cellular identity and energy homeostasis.
Arnold Tan +9 more
openalex +5 more sources