Results 21 to 30 of about 6,787 (222)

PARylation of 14-3-3 proteins controls the virulence of Magnaporthe oryzae

Nature Communications
Magnaporthe oryzae is a devastating fungal pathogen that causes the rice blast disease worldwide. The post-translational modification of ADP-ribosylation holds significant importance in various fundamental biological processes.
Xiuqin Gao, Gaigai Gao, Weifeng Zheng, Haibing Liu, Wenbo Pan, Xi Xia, Dongmei Zhang, Wenwei Lin, Zonghua Wang, Baomin Feng   +9 more
doaj   +3 more sources

HTATSF1-Nucleated PARylation and Phosphorylation Cascade Dictates Homologous Recombination and Modulates Chemotherapeutic Response of Breast Carcinoma

Molecular Cell, 2021
Zhao et al. (2022) demonstrate that HIV Tat-specific factor 1, an RPA PARylation reader, recruits Topoisomerase IIβ-binding protein 1 to double-strand break sites specifically in the S phase of the cell cycle to promote homologous recombination.
Jiao Zhao, Shanshan Tian, Qiushi Guo, Jieyou Zhang, Guohui Yu, Xiaodan Wang, Xilin Shen, Ying Yang, Ling Liu, Xiangchun Li, Jihui Hao, Na Yang, Ding Ai, Jie Yang, Zhi Yao, Shuai Ma, Kai Zhang, Lei Shi   +17 more
openalex   +3 more sources

S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion [PDF]

EMBO J
Meiqian Jiang, Jiaxin Zhang, Jianfeng He, Miao Yu, Linhui Wang, Haitao Zhong, Yingying Gong, Zhen Li, Li‐Lin Du, Xingzhi Xu, Chunlai Chen, Alibek Ydyrys, Yisui Xia, Qinhong Cao, Huiqiang Lou, Wenya Hou   +15 more
openalex   +2 more sources

ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes

Cell Reports
Summary: The majority of severe early-onset and juvenile cases of amyotrophic lateral sclerosis (ALS) are caused by mutations in the FUS gene, resulting in rapid disease progression.
David Vilchez
exaly   +3 more sources

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer [PDF]

Cell Death Discovery
Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC). Altered DNA repair and metabolic signaling is implicated in mediating therapeutic resistance.
Ganesh Acharya, Chinnadurai Mani, Naresh Sah, Karunakar Saamarthy, Robert J. Young, Mark B. Reedy, Robert W. Sobol, Komaraiah Palle   +7 more
openalex   +2 more sources

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1 [PDF]

Nucleic Acids Research, 2017
Muwen Kong, Bret D Freudenthal, Rajendra Prasad   +2 more
exaly   +2 more sources

Noncovalent PAR Binding Guides Proteins to PARP1-Mediated PARylation [PDF]

ACS Chem Biol
Arthur Fischbach, Klara Bangert, Alexander Bürkle, Aswin Mangerich   +3 more
openalex   +2 more sources

The lncRNA PARylator promotes PARP1 activation and resistance to DNA‑damaging therapy in esophageal squamous cell carcinoma [PDF]

Experimental Hematology & Oncology
Background Outcomes for patients with esophageal squamous cell carcinoma (ESCC) remain poor, partly due to treatment resistance, particularly to DNA-damaging therapies.
Teng Fei Qi, Yadong Liu, Jinkun Yang, Yi Meng Yue, Man Man Han, Hongtao Liu, Jing Li, Min Liu, Yuwei Zhang, Jia Hui Kou, Wen Jin Li, Xiaoying Liu, Ting La, Tao Liu, Song Chen, Xu Dong Zhang, Shundong Cang, Liu Teng, Tianli Fan   +18 more
doaj   +2 more sources

Histone PARylation factor 1: a review of its role in the DNA damage response [PDF]

Nucleic Acids Res
Johannes Rudolph, Karolin Luger
openalex   +2 more sources

NAMPT and PARylation Are Involved in the Pathogenesis of Atopic Dermatitis [PDF]

International Journal of Molecular Sciences, 2023
Atopic dermatitis (AD) is a chronic inflammatory skin disease of very high prevalence, especially in childhood, with no specific treatment or cure. As its pathogenesis is complex, multifactorial and not fully understood, further research is needed to increase knowledge and develop new targeted therapies.
Ana B. Arroyo, Martín Bernal-Carrión, Joaquín Cantón-Sandoval, Isabel Cabas, R. Corbalán-Vélez, Teresa Martínez‐Menchón, Belén Ferri, María L. Cayuela, Diana García‐Moreno, Víctoriano Mulero   +9 more
openalex   +3 more sources