Results 21 to 30 of about 5,280 (145)

SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis

eLife
RNA binding proteins (RBPs) containing intrinsically disordered regions (IDRs) are present in diverse molecular complexes where they function as dynamic regulators.
Kira Breunig, Xuifen Lei, Mauro Montalbano, Gabriela DA Guardia, Shiva Ostadrahimi, Victoria Alers, Adam Kosti, Jennifer Chiou, Nicole Klein, Corina Vinarov, Lily Wang, Mujia Li, Weidan Song, W Lee Kraus, David S Libich, Stefano Tiziani, Susan T Weintraub, Pedro AF Galante, Luiz O Penalva   +18 more
doaj   +3 more sources

Noncovalent PAR Binding Guides Proteins to PARP1-Mediated PARylation. [PDF]

ACS Chem Biol
Poly(ADP-ribosyl)ation (PARylation) is a highly dynamic post-translational modification mediated by poly(ADP-ribose) polymerases (PARPs), influencing DNA damage response, transcription, and cell death.
Fischbach A, Bangert K, Bürkle A, Mangerich A.   +3 more
europepmc   +2 more sources

PARP-1 and PARylation inhibit TET1 demethylation activity

, 2020
Since our previous work indicated interplay of Ten-eleven translocation (TET) and Poly (ADP-ribose) polymerase (PARP) proteins our aim was to further study the effects of their interaction.
Uskoković, Aleksandra, Vidaković, Melita, Mihailović, Mirjana, Arambašić Jovanović, Jelena, Đorđević, Marija, Nestorović, Nataša, Tolić, Anja, Rajić, Jovana, Đorđević, Miloš, Grdović, Nevena, Jurkowski, Tomasz, Dinić, Svetlana   +11 more
core   +5 more sources

YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression

Journal of Translational Medicine
Background Neuroblastoma (NB), the most prevalent solid tumor in children, arises from sympathetic nervous system and accounts for 15% of pediatric cancer mortality.
Chunhui Yang, Jiaying Qu, Yang Cheng, Minxiu Tian, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Yanhua Guo, Liduan Zheng, Qiangsong Tong   +11 more
doaj   +2 more sources

PolyADP-ribosylation is required for pronuclear fusion during postfertilization in mice. [PDF]

PLoS ONE, 2010
BACKGROUND: During fertilization, pronuclear envelope breakdown (PNEB) is followed by the mingling of male and female genomes. Dynamic chromatin and protein rearrangements require posttranslational modification (PTM) for the postfertilization development.
Tomoharu Osada, Hideki Ogino, Toshiaki Hino, Sachiyo Ichinose, Kenji Nakamura, Akira Omori, Toshiaki Noce, Mitsuko Masutani   +7 more
doaj   +1 more source

The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy

Acta Pharmaceutica Sinica B, 2021
The bromodomain and extraterminal (BET) family member BRD4 is pivotal in the pathogenesis of cardiac hypertrophy. BRD4 induces hypertrophic gene expression by binding to the acetylated chromatin, facilitating the phosphorylation of RNA polymerases II ...
Zhenzhen Li, Zhen Guo, Rui Lan, Sidong Cai, Zhirong Lin, Jingyan Li, Junjian Wang, Zhuoming Li, Peiqing Liu   +8 more
doaj   +1 more source

HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase

eLife, 2021
Poly(ADP-ribose) polymerase 1 (PARP1) is an important player in the response to DNA damage. Recently, Histone PARylation Factor (HPF1) was shown to be a critical modulator of the activity of PARP1 by facilitating PARylation of histones and redirecting ...
Johannes Rudolph, Genevieve Roberts, Uma M Muthurajan, Karolin Luger   +3 more
doaj   +1 more source

Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage

Cell Communication and Signaling, 2022
Background N-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been implicated in Hutchinson-Gilford progeria syndrome and human cancer.
Hong-Yi Liu, Ying-Ying Liu, Yin-Ling Zhang, Yan Ning, Fang-Lin Zhang, Da-Qiang Li   +5 more
doaj   +1 more source

PARP1 PARylates and stabilizes STAT5 in FLT3-ITD acute myeloid leukemia and other STAT5-activated cancers

Translational Oncology, 2022
Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD ...
Anna J. Dellomo, Rachel Abbotts, Christian L. Eberly, Mariusz Karbowski, Maria R. Baer, Tami J. Kingsbury, Feyruz V. Rassool   +6 more
doaj   +1 more source

Abstract CT269: A highly sensitive and specific PARylation assay confirms significant and durable target engagement by AZD5305 in patients [PDF]

, 2023
Background AZD5305 is a selective PARP1 inhibitor (PARPi) generated for improved therapeutic index compared with non-selective PARPi. Measurement of PARylation inhibition has been used to determine the pharmacodynamics (PD) of PARPi in clinical trials ...

core   +2 more sources