Results 31 to 40 of about 5,280 (145)

Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus [PDF]

, 2021
Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease.
L. Bertoccini, M. G. Cavallo, Cavallo, Maria Gisella, Zardo, Giuseppe, Tagliatesta, Stefano, M. G. Bacalini, Barchetta, Ilaria, G. De Matteis, Scalea, Stefania, S. Scalea, Bertoccini, Laura, A. Reale, Reale, Anna, G. Zardo, De Matteis, Giovanna, S. Tagliatesta, Bacalini, Maria Giulia, M. Zampieri, Zampieri, Michele, Cimini, Flavia Agata, I. Barchetta, F. A. Cimini   +21 more
core   +1 more source

Targeting dePARylation for cancer therapy

Cell & Bioscience, 2020
Poly(ADP-ribosyl)ation (PARylation) mediated by poly ADP-ribose polymerases (PARPs) plays a key role in DNA damage repair. Suppression of PARylation by PARP inhibitors impairs DNA damage repair and induces apoptosis of tumor cells with repair defects ...
Muzaffer Ahmad Kassab, Lily L. Yu, Xiaochun Yu   +2 more
doaj   +1 more source

Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation

Acta Pharmaceutica Sinica B, 2019
The clinical application of doxorubicin (DOX) in cancer chemotherapy is limited by its life-threatening cardiotoxic effects. Chrysophanol (CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role ...
Jing Lu, Jingyan Li, Yuehuai Hu, Zhen Guo, Duanping Sun, Panxia Wang, Kaiteng Guo, Dayue Darrel Duan, Si Gao, Jianmin Jiang, Junjian Wang, Peiqing Liu   +11 more
doaj   +1 more source

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context

Scientific Reports, 2021
The regulation of repair processes including base excision repair (BER) in the presence of DNA damage is implemented by a cellular signal: poly(ADP-ribosyl)ation (PARylation), which is catalysed by PARP1 and PARP2.
M. M. Kutuzov, E. A. Belousova, T. A. Kurgina, A. A. Ukraintsev, I. A. Vasil’eva, S. N. Khodyreva, O. I. Lavrik   +6 more
doaj   +1 more source

ADP-Ribosylation and Antiviral Resistance in Plants

Viruses, 2023
ADP-ribosylation (ADPRylation) is a versatile posttranslational modification in eukaryotic cells which is involved in the regulation of a wide range of key biological processes, including DNA repair, cell signalling, programmed cell death, growth and ...
Nadezhda Spechenkova, Natalya O. Kalinina, Sergey K. Zavriev, Andrew J. Love, Michael Taliansky   +4 more
doaj   +1 more source

PARylation modulates the demethylation process in type 2 diabetes mellitus

, 2023
DNA methylation can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease. Our previous studies demonstrated that the regulation of the DNA methylation pattern involved the PARylation process, a post ...
Bacalini M. G., Zardo G., Zampieri M., Karpach K., Reale A.   +4 more
core   +1 more source

PARP1-MGMT complex underpins pathway crosstalk in O6-methylguanine repair

Journal of Hematology & Oncology, 2022
DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and the other mediated by O6-methylguanine (O6meG)-DNA methyltransferase (MGMT) in a single-step ...
Jodie D. Cropper, Dauren S. Alimbetov, Kevin T. G. Brown, Rostislav I. Likhotvorik, Andrew J. Robles, James T. Guerra, Boxue He, Yidong Chen, Youngho Kwon, Raushan T. Kurmasheva   +9 more
doaj   +1 more source

Role of PARP-1 in Human Cytomegalovirus Infection and Functional Partners Encoded by This Virus

Viruses, 2022
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that threats the majority of the world’s population. Poly (ADP-ribose) polymerase 1 (PARP-1) and protein poly (ADP-ribosyl)ation (PARylation) regulates manifold cellular functions.
Wenchang Zhang, Jing Guo, Qiang Chen
doaj   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy

, 2020
Poly-ADP-ribosylation (PARylation) is a fully reversible post-translational modification with key roles in cellular physiology. Due to the multi-domain structure of poly(ADP-ribose) polymerase-1 (PARP1) and the highly dynamic nature of the PARylation ...
Krüger, Annika, Hauser, Karin, Bürkle, Alexander, Mangerich, Aswin   +3 more
core   +1 more source