Poly(ADP-ribosyl)ation Acts in the DNA Demethylation of Mouse Primordial Germ Cells Also with DNA Damage-Independent Roles [PDF]
, 2012 Poly(ADP-ribosyl)ation regulates chromatin structure and transcription driving epigenetic events. In particular, Parp1 is able to directly influence DNA methylation patterns controlling transcription and activity of Dnmt1.
Bacalini, M +7 more
core +20 more sources
NUDT16 regulates CtIP PARylation to dictate homologous recombination repair [PDF]
Nucleic Acids ResearchAbstract CtIP initiates DNA end resection and mediates homologous recombination (HR) repair. However, the underlying mechanisms of CtIP regulation and how the control of its regulation affects DNA repair remain incompletely characterized.
Zhen Zhang, William E. Samsa, Zihua Gong
openalex +3 more sources
Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus [PDF]
Clinical Epigenetics, 2021 Abstract Background Epigenetic modifications, such as DNA methylation, can influence the genetic susceptibility to type 2 diabetes mellitus (T2DM) and the progression of the disease. Our previous studies demonstrated that the regulation of the DNA methylation pattern involves the poly(ADP-ribosyl)ation (PARylation ...
Michele Zampieri +10 more
openalex +5 more sources
PolyADP-ribosylation is required for pronuclear fusion during postfertilization in mice. [PDF]
PLoS ONE, 2010 BACKGROUND: During fertilization, pronuclear envelope breakdown (PNEB) is followed by the mingling of male and female genomes. Dynamic chromatin and protein rearrangements require posttranslational modification (PTM) for the postfertilization development.
Tomoharu Osada +7 more
doaj +1 more source
PC4-mediated Ku complex PARylation facilitates NHEJ-dependent DNA damage repair [PDF]
Journal of Biological Chemistry, 2023 Radiotherapy is one of the mainstay treatments for hepatocellular carcinoma (HCC). However, a substantial number of patients with HCC develop radioresistance and eventually suffer from tumor progression or relapse, which is a major impediment to the use of radiotherapy.
Qimei Pan, Peng Luo, Chunmeng Shi
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PARP1-mediated PARylation of TonEBP prevents R-loop–associated DNA damage
DNA Repair, 2021 Lack of coordination between the DNA replication and transcription machineries can increase the frequency of transcription-replication conflicts, leading ultimately to DNA damage and genomic instability. A major source of these conflicts is the formation of R-loops, which consist of a transcriptionally generated RNA-DNA hybrid and the displaced single ...
Byeong Jin Ye +4 more
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The poly(ADP-ribosyl)ation of BRD4 mediated by PARP1 promoted pathological cardiac hypertrophy
Acta Pharmaceutica Sinica B, 2021 The bromodomain and extraterminal (BET) family member BRD4 is pivotal in the pathogenesis of cardiac hypertrophy. BRD4 induces hypertrophic gene expression by binding to the acetylated chromatin, facilitating the phosphorylation of RNA polymerases II ...
Zhenzhen Li +8 more
doaj +1 more source
Tipping the PARylation scale: Dysregulation of PAR signaling in Huntington and neurodegenerative diseases [PDF]
J Huntingtons DisChristina Peng +2 more
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HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase
eLife, 2021 Poly(ADP-ribose) polymerase 1 (PARP1) is an important player in the response to DNA damage. Recently, Histone PARylation Factor (HPF1) was shown to be a critical modulator of the activity of PARP1 by facilitating PARylation of histones and redirecting ...
Johannes Rudolph +3 more
doaj +1 more source
Translational Oncology, 2022 Signal transducer and activator of transcription 5 (STAT5) signaling plays a pathogenic role in both hematologic malignancies and solid tumors. In acute myeloid leukemia (AML), internal tandem duplications of fms-like tyrosine kinase 3 (FLT3-ITD ...
Anna J. Dellomo +6 more
doaj +1 more source