Results 51 to 60 of about 5,280 (145)

The PARP1-Siah1 Axis Controls HIV-1 Transcription and Expression of Siah1 Substrates

Cell Reports, 2018
Summary: Recent studies have revealed a key role of PARP1 that catalyzes the poly-ADP-ribosylation (PARylation) of substrates in regulating gene transcription. We show here that HIV-1 transcriptional activation also requires PARP1 activity.
Dan Yu, Rongdiao Liu, Geng Yang, Qiang Zhou   +3 more
doaj   +1 more source

The Role of PARylation in Skeletal Muscle During the Development of Cancer Cachexia

, 2023
Cancer cachexia is a wasting syndrome causing involuntary weight loss and muscle atrophy. PARP1 is a nicotinamide dinucleotide-dependent enzyme that modifies target proteins by PARylation.
Nik-Akhtar, Abolfazl
core   +1 more source

Streptavidin-Conjugated DNA for the Boronate Affinity-Based Detection of Poly(ADP-Ribose) Polymerase-1 with Improved Sensitivity

Biosensors, 2023
This work reports the development of a fluorescence method for the detection of poly(ADP-ribose) polymerase-1 (PARP1), in which a phenylboronic acid-modified fluorescein isothiocyanate dye (FITC-PBA) was used to recognize the formed poly(ADP-ribose) (PAR)
Fengli Gao, Gang Liu, Yishu Qiao, Xiuwen Dong, Lin Liu   +4 more
doaj   +1 more source

Structure‐Based Design, Synthesis, and Biological Evaluation of Oxadiazole–Morpholine Hybrids as Potent PARP‐1 Inhibitors Inducing Apoptosis in Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Poly(ADP‐ribose) polymerase‐1 (PARP‐1) plays a central role in the repair of DNA single‐strand breaks and represents an established therapeutic target in cancer treatment. In this study, a series of novel oxadiazole–morpholine hybrid compounds was designed and synthesized using a structure‐based drug design approach to target the catalytic ...
Nader R. Albujuq, Khaled M. Darwish, Sherif Ashraf Fahmy, Buthaina Hussein, Ghada G. Kayed, Musa A. Said, Mohamed S. Nafie   +6 more
wiley   +1 more source

Arabidopsis WSS1A, a DNA‐protein crosslink repair protease, delays leaf senescence in cooperation with SUMO3

The Plant Journal, Volume 127, Issue 4, August 2026.
SUMMARY Leaf senescence, the final stage of leaf development, is regulated by complex interplays of intrinsic genetic programs and environmental cues. Throughout their lifetimes, all living organisms encounter various endogenous and environmental challenges, many of which can cause potentially fatal DNA damage. Among these, DNA‐protein crosslinks (DPCs)
Sanghoon Park, Hyunwoo Oh, Ukcheol Jeong, Jae Ho Lee, Hyeyoung Choi, Hyunsu Park, Jinkwang Kim, Yongmin Kim, Junmin Kwak, Yeong Seon Yoon, Zhonghai Li, Jong‐Chan Lee, Hye Ryun Woo   +12 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, Volume 16, Issue 7, Page 1370-1386, July 2026.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, Volume 13, Issue 40, 17 July 2026.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Proteasome inhibitor induces PARylation of TNKSs and TNKSi reduces basal PARylation levels.

, 2016
A. SW480 and HEK293 cells were exposed to combinations of TNKSi (G007-LK) and MG132 treatments similar to that shown in legend to Fig 3. The cells were then lysed and extracts analysed by IP assay using a specific antibody against PAR. PARylated forms of
Estefania Martino-Echarri (2548186), Kate M. Mills (2548180), Beric R. Henderson (2548177), Mariana G. Brocardo (2548183)   +3 more
core   +1 more source

The Chemical Regulatory Landscape of Biomolecular Condensates

Aggregate, Volume 7, Issue 7, July 2026.
Chemical regulation of biomolecular phase separation offers a unique opportunity to bridge molecular‐level chemistry with emergent cellular organization. Chemically informed strategies for controlling condensate condensates through chemically tractable parameters such as interaction valency, solvent quality, and molecular crowding provides a unifying ...
Di Liu, Xin Zhang
wiley   +1 more source

The dynamic process of covalent and non-covalent PARylation in the maintenance of genome integrity: a focus on PARP inhibitors

, 2023
Poly(ADP-ribosylation) (PARylation) by poly(ADP-ribose) polymerases (PARPs) is a highly regulated process that consists of the covalent addition of polymers of ADP-ribose (PAR) through post-translational modifications of substrate proteins or non ...
Guy G Poirier, Jean-Philippe Gagné, Nonfoux, L, Poirier, GG, Masson, J-Y, Adèle Beneyton, Nurgul Atalay, Jean-Yves Masson, Charu Kothari, Amélie Rodrigue, Kothari, C, Louis Nonfoux, Gagné, J-P, Beneyton, A, Atalay, N, Michael J Hendzel, Hendzel, MJ, Rodrigue, A   +17 more
core   +1 more source