Results 71 to 80 of about 5,280 (145)
Dual PARP/Tankyrase Inhibition Enhances Antitumor Efficacy in PTEN‐Deficient Endometrial Cancer
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Endometrial cancer (EC) incidence continues to rise, underscoring the need for effective therapies beyond BRCA‐mutant disease. Although PTEN loss, a frequent alteration in EC, has been implicated in impaired homologous recombination and increased sensitivity to PARP inhibitors, responses to PARP inhibitor monotherapy remain variable and are ...
Sung Wan Kang +6 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
, 2018 A study of the in vitro inhibition of hPARP-1 enzyme and PARylation of HeLa cells by a wide range of PARP inhibitors has been conducted utilizing an established linear free energy methodology comprising the free energy of water desolvation and ...
Fong, Clifford, W
core +3 more sources
The Role of PARylation in Inflammatory Mediated Subclass of Preeclampsia
Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality, diagnosed after 20 weeks of gestation. Several subclasses of PE have been identified, each with distinct pathophysiology.
Vanegas Pineda, Sophia
core +1 more source
Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1
, 2023 Single-molecule Förster resonance energy transfer (FRET) data supporting the findings of the paper titled "Asymmetric nucleosome PARylation at DNA breaks mediates directional nucleosome sliding by ALC1" in Nature Communications.
Sebastian Deindl (6114824) +8 more
core +1 more source
RUNX Poly(ADP-Ribosyl)ation and BLM Interaction Facilitate the Fanconi Anemia Pathway of DNA Repair
Cell Reports, 2018 Summary: The Fanconi anemia (FA) pathway is a pivotal genome maintenance network that orchestrates the repair of DNA interstrand crosslinks (ICLs). The tumor suppressors RUNX1 and RUNX3 were shown to regulate the FA pathway independent of their canonical
Lavina Sierra Tay +8 more
doaj +1 more source
Life Science AllianceOur current work demonstrates that the non-covalent PARylation of HuR plays a key role in regulating its pro-apoptotic function by preventing its cytoplasmic localization and cleavage.
Kholoud Ashour +11 more
doaj +1 more source
Redox BiologyBackground: Type 2 diabetes mellitus (T2DM) is characterized by disrupted glucose homeostasis and metabolic abnormalities, with oxidative stress and inflammation playing pivotal roles in its pathophysiology.
Michele Zampieri +12 more
doaj +1 more source
USP1 deubiquitinates PARP1 to regulate its trapping and PARylation activity [PDF]
PARP inhibitors (PARPi) represent a game-changing treatment for patients with ovarian cancer with tumors deficient for the homologous recombination (HR) pathway treated with platinum (Pt)–based therapy. PARPi exert their cytotoxic effect by both trapping
Sonego, Maura +20 more
core +2 more sources
Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase
Advances in Virology, 2019 Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans.
Liset Westera +5 more
doaj +1 more source