Results 81 to 90 of about 6,787 (222)

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

EMBO Reports
Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl)ation (PARylation). The enrichment of DNA repair proteins at sites of DNA
Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Hongshan Zhang, Michael L Nosella, Morgan Dasovich, T Reid Alderson, Anthony K L Leung, Ilya J Finkelstein, Julie D Forman-Kay, Hyun O Lee   +10 more
doaj   +1 more source

Poly(ADP-Ribosyl)ation Affects Histone Acetylation and Transcription.

PLoS ONE, 2015
Poly(ADP-ribosyl)ation (PARylation) is a posttranslational protein modification catalyzed by members of the poly(ADP-ribose) polymerase (PARP) enzyme family.
Loredana Verdone, Marco La Fortezza, Fabio Ciccarone, Paola Caiafa, Michele Zampieri, Micaela Caserta   +5 more
doaj   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Visualization of a DNA-PK/PARP1 complex [PDF]

, 2012
The DNA-dependent protein kinase (DNA-PK) and Poly(ADP-ribose) polymerase-1 (PARP1) are critical enzymes that reduce genomic damage caused by DNA lesions.
Barbeau, Jody, Curtin, Nicola J, Morris, Edward P, Pearl, Laurence H, Spagnolo, Laura   +4 more
core   +3 more sources

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

In Vitro Evaluation of PARP1 Inhibitor Olaparib‐Cyanine Dye Conjugate for the Treatment of Glioblastoma

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Inhibition of DNA damage repair is a common mechanism to induce cancer cell death and, therefore, to treat cancers such as breast, prostate and ovarian cancer. This approach, although very attractive, has not been feasible for treating brain tumours due to the stringent structural features necessary for pharmaceutical agents to cross the blood–brain ...
Carina Dumo, Faheem, Peter J. Choi, Nicholas J. Pederson, Yuge Liu, Mike Dragunow, Thomas I‐H. Park, Katharine L. Diehl, Jiney Jose   +8 more
wiley   +1 more source

Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila [PDF]

, 2023
Shanshan Guo, Shuang Zhang, Yixiao Zhuang, Famin Xie, Ruwen Wang, Xingyu Kong, Qiongyue Zhang, Yonghao Feng, Huanqing Gao, Xingxing Kong, Tiemin Liu   +10 more
openalex   +1 more source

PARylation-centric crosstalk: orchestrating immune evasion and multidrug resistance in ovarian cancer

Frontiers in Immunology
Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance.
Lin Hou, Lin Hou, Mengwen Zhang, Mengwen Zhang, Weihua Tong, Songling Zhang, Songling Zhang   +6 more
doaj   +1 more source

CIAdex: Label‐Free Cell Identification and Aging Quantification Using Single‐Cell Infrared Spectral Fingerprints

Advanced Photonics Research, Volume 7, Issue 4, April 2026.
Cell Identification and Aging Index (CIAdex) harnesses single‐cell infrared spectral fingerprints to provide label‐free cell identification and quantitative aging assessment. By integrating machine learning with Fourier‐transform infrared (FTIR) microspectroscopy, this framework distinguishes cell types, donors, and batches while tracking aging ...
Ying Wang, Yanfei Ding, Chengzhang He, Xiaojie Zhou, Junwu Tu, Yulei Deng, Jian Zhao   +6 more
wiley   +1 more source

Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation [PDF]

, 2017
The Parkinson's disease (PD)-related protein F-box only protein 7 (Fbxo7) is the substrate-recognition component of the Skp1-Cullin-F-box protein E3 ubiquitin ligase complex.
Abramov, AY, Delgado-Camprubi, M, Esteras, N, Plun-Favreau, H, Soutar, MP   +4 more
core   +1 more source