Results 81 to 90 of about 5,280 (145)

NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair

Cell Reports, 2019
Summary: Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood.
Deeksha Munnur, Joanna Somers, George Skalka, Ria Weston, Rebekah Jukes-Jones, Mohammed Bhogadia, Cyril Dominguez, Kelvin Cain, Ivan Ahel, Michal Malewicz   +9 more
doaj   +1 more source

PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1

Cell Reports
Summary: Persistent DNA-protein crosslinks formed by human topoisomerase IIIα (TOP3A-DPCs) interfere with DNA metabolism and lead to genome damage and cell death.
Liton Kumar Saha, Yilun Sun, Sourav Saha, Xi Yang, Yves Pommier   +4 more
doaj   +1 more source

Role of PARylation on cardiovascular disease in Hutchinson-Gilford progeria syndrome

, 2022
La progéria de Hutchinson-Gilford (HGPS) est une maladie génétique rare causée dans la majorité des cas par une mutation du gène LMNA. Cette mutation conduit à l’expression d’une lamine A mutée appelée "progérine".
Cardoso, Déborah
core  

PARylation affects binding of transcription factors and histone H1 differently dependent on the binding site.

, 2012
Preparation of chromatin and ChIP was done by JLI and BMB protocol, respectively. Three independent chromatin preparations were analyzed by three independent PCRs each (panels A, C), or by only one PCR each (panel B) due to lack of material.
Anja Holtz (174441), Alexander Bürkle (27570), Kirstin Meyer (174440), Katharina Hüttner (174442), Sascha Beneke (174438)   +4 more
core   +1 more source

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Advanced Science
Metabolic dysregulation has been implicated as a key factor in colorectal cancer (CRC) initiation, however, the underlying driving forces and mechanisms remain poorly understood.
Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, Shuidan Xu, Dan Xie, Fengwei Wang   +12 more
doaj   +1 more source

Abstract 4487: A critical role of PARylation in regulating the functions of OVOL2

, 2017
Poly(ADP-ribosyl)ation (PARylation) is one of the post-translational modifications, by which the ADP-ribose (PAR) polymers are added to the specific protein by a PAR polymerase (PARP).
Rui Zhang, Yih-Cherng Liou, Boan Li
core   +1 more source

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer

Cell Death Discovery
Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC). Altered DNA repair and metabolic signaling is implicated in mediating therapeutic resistance.
Ganesh Acharya, Chinnadurai Mani, Naresh Sah, Karunakar Saamarthy, Robert Young, Mark B. Reedy, Robert W. Sobol, Komaraiah Palle   +7 more
doaj   +1 more source

Stable and Reusable Electrochemical Biosensor for Poly(ADP-ribose) Polymerase and Its Inhibitor Based on Enzyme-Initiated Auto-PARylation

, 2016
A stable and reusable electrochemical biosensor for the label-free detection of poly­(ADP-ribose) polymerase (PARP) is designed in this work. C-kit-1, a thiol-modified G-quadruplex oligonucleotide, is first self-assembled on a gold electrode surface. The
Zhihui Dai (703839), Li Liu (75607), Yuanyuan Xu (163995), Zhaoyin Wang (1411786)   +3 more
core   +1 more source

Rôle de la PARylation sur l’apparition des troubles cardiovasculaires dans la progéria de Hutchinson-Gilford

, 2022
Introduction | Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder mimicking clinical and molecular features of accelerated aging.
Cardoso, Deborah
core  

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage. [PDF]

Nat Commun
Thomas QA, Wu L, Lesage E, Iversen HKM, López Martínez D, Kompocholi S, Liu H, Nieto Moreno N, Gregersen LH.   +8 more
europepmc   +2 more sources